Serum Levels of 8-Ohdg in Patients With Hashimoto’S Thyroiditis; [Hashimoto Tiroiditi Olan Hastalarda Serum 8-Ohdg Duzeyleri] Publisher



Esfahanian F¹ ; Fotouk Kiaie SM¹ ; Ghelich R¹ ; Jadali Z²
Source: Turkish Journal of Endocrinology and Metabolism Published:2020

Abstract

Objective: A growing body of evidence shows a close relationship between oxidative stress and autoimmune conditions such as Hashimoto’s thyroiditis (HT). Among different markers of oxidative damage, 8-hydroxydeoxyguanosine (8-OHdG) is a ubiquitous marker and broadly used in research studies. Therefore, this study aimed to measure the level of 8-OHdG in the sera of patients with HT and healthy control (HC) participants. Material and Methods: In this study, patients were diagnosed with clinical (n=23) and subclinical (n=25) hypothyroidism because of HT and compared with 35 healthy participants. 8-OHdG was measured using enzyme-linked immunosorbent assay in patients and HC participants. Results: No significant difference was observed in the mean serum 8-OHdG levels between patients and HC participants. Conclusion: The results of this preliminary study do not support the fact that the serum level of 8-OHdG is a biomarker of oxidative stress in patients with HT. However, more detailed studies are needed to reveal the exact role of 8-OHdG in this autoimmune disease of the thyroid gland. © 2020 by Society of Endocrinology and Metabolism of Turkey. Publication and hosting by Turkiye Klinikleri.