The Comparison of the Effectiveness of in Travenous Morphine With Oral Pregabalin With Intravenous Morphine on Pain Intensity of Limb Fractured Patients Admitted to the Emergency Department



Hoseini SM¹ ; Zare MA^{2, 3} ; Tavakoli N^{2, 3} ; Ghafoori HB^{2, 3} ; Chahardoli M^{2, 3} ; Yasinzadeh M^{2, 3} ; Rahimzadeh P^{2, 3} Show Affiliations
Source: Annals of Tropical Medicine and Public Health Published:2018

Abstract

Objective: Given that one of the important aspects of physicians working is pain management in emergency ward (room), as well as patients with extremity fractures are one of the most important and most common groups who need for pain management in the emergency ward (unit), this study aimed to investigate the effectiveness of intravenous morphine with oral Pregabalin with intravenous morphine on the pain intensity of limb fractured patients admitted to the emergency admitted to emergency wards. Methods: This study is a randomized double-blind placebo-controlled trial. The study population included patients with acute limb fracture at the age of ≥ 18 years in ( emergency wards) hospitals of Shohadae Hafte Tir , Firoozgar and the Prophet (PBUH) Rasoole Akram in Tehran in 2015. 232 patients were enrolled in this study that 32 patients because of failure to achieving criteria exclusion were excluded. 200 patients were randomly divided into two equal groups double-blind. The first group received 5 mg morphine intravenous + oral placebo and the second group received 5 mg intravenous morphine +300 mg oral Pregabalin. Pain severity using standard VNRS before receiving pain killer medication and then 30, 90, 150, 210, 270, 330 and 390 minutes after the first dose was measured and recorded. Data analysis was performed using SPSS software version 16 and the significance level was considered less than 0/05. Results: The intensity of pain in patients before prescribing painkillers and 30 minutes after intervention showed no significant difference (P-value<0/05). Patients who received in addition to morphine also Pregabalin sulfate had less pain intensity in the time period of 90, 270, 330 and 390 minutes after administration compared with controls. Conclusion: According to results of this study to better control pain in patients with extremity fractures single dose of pregabalin with the analgesic morphine sulfate injection which is a standardized painkiller of emergency room can be used. © 2018 Wolters Kluwer Medknow Publications. All rights reserved.