Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Effect of Pregabalin on Morphine Consumption, Sleep, Mood and Ability to Change Position After Colorectal Cancer Surgery Publisher



Taheri A1 ; Arjmandnia F1 ; Majedi H2 ; Kazemeini A3 ; Yousefshahi F1 ; Rahimi M1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Anesthesiology, Critical Care and Pain Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Colorectal Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Trauma Monthly Published:2021


Abstract

Introduction: Pregabalin is a co-analgesic to improve the pain control after colorectal cancer surgeries. There is less knowledge about the effect of Pregabalin on postoperative sleep and the ability to change the position of patients after surgery. This study aimed to assess the impact of Pregabalin on postoperative morphine consumption, pain, sleep, mood, and ability to change position after colorectal cancer surgery. Methods: This double-blind, randomized, controlled, single-center clinical trial was performed in Tehran, Iran, from June 2017 to June 2018. Seventy patients were included for colorectal cancer surgery randomly divided into two groups (A, B). Group A received two doses Pregabalin (150 mg) pre-operative and post-operative, and group B as a placebo was administered at the same scheme. The two groups had similar analgesia and anesthesia regimens. The pain was scored by a numerical rating scale (NRS); disturbance in sleep, and mood. The daily activity was numbered based on a scoring system such as BPI questionnaires; and, nausea- vomiting, morphine consumption, and fatigue headache were evaluated 48 hours after surgery. Results: Morphine consumption was lower in the Pregabalin group 24 h after surgery (P=0.01). The two groups were similar regarding sleep interference scores and side effects (P>0.05). But, mood and actions interference scores in the Pregabalin group showed a significant improvement in 48 h postoperative (P<0.05) (Table 3). Conclusion: The results showed that Pregabalin could reduce postoperative morphine consumption and improve mood and actions interference scores after colorectal cancer surgery. However, there was no difference between Pregabalin and placebo in postoperative pain management and sleep interference scores after colorectal cancer surgery. Copyright © 2021 The Author(s)
Related Docs
View other Related Docs
1. Dose Ranging Effects of Pregabalin on Pain in Patients Undergoing Laparoscopic Hysterectomy: A Randomized, Double Blinded, Placebo Controlled, Clinical Trial, Journal of Clinical Anesthesia (2017)
2. Management of Postoperative Pain After Lumbar Surgery—Pregabalin for One Day and 14 Days—A Randomized, Triple-Blinded, Placebo-Controlled Study, Clinical Neurology and Neurosurgery (2016)
3. Preoperative Gabapentin to Prevent Postoperative Shoulder Pain After Laparoscopic Ovarian Cystectomy: A Randomized Clinical Trial, Anesthesiology and Pain Medicine (2015)
4. The Comparison of the Effectiveness of in Travenous Morphine With Oral Pregabalin With Intravenous Morphine on Pain Intensity of Limb Fractured Patients Admitted to the Emergency Department, Annals of Tropical Medicine and Public Health (2018)
5. Pregabalin and Gabapentin in Neuropathic Pain Management After Spinal Cord Injury: A Systematic Review and Meta-Analysis, Korean Journal of Pain (2020)
6. Comparison of the Analgesic Effects of Single-Dose 75 Mg Oral Pregabalin Versus Single-Dose 400 Mg Oral Ibuprofen After Impacted Third Mandibular Molar Surgery: A Randomized, Double-Blind, Split-Mouth Clinical Trial, Dental and Medical Problems (2023)
7. Evaluation of Post Laparoscopic Cholecystectomy Pain After Subcutaneous Injection of Lidocaine at Port Site Versus Lidocaine Spray on Gallbladder Bed After Cholecystectomy: A Randomized Controlled Trial, Langenbeck's Archives of Surgery (2022)
8. Study of Pregabalin Effect on Postsurgical Pain in Breast Cancer Patients: A Double-Blind Randomized Clinical Trial Using Placebo, Breast Journal (2020)
Experts (# of related papers)
View all Related Experts
Mojtaba Sedaghat (1)
Mohammad Zarei (1)
Other Related Docs
9. Low-Dose Preoperative Pregabalin Improves Postoperative Pain Management in Septorhinoplasty Surgery: A Double-Blind Randomized Clinical Trial, European Archives of Oto-Rhino-Laryngology (2019)