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Hpv Infections in Retinoblastoma: A Systematic Review Publisher Pubmed



Soltani S1, 2 ; Tabibzadeh A3 ; Yousefi P3 ; Zandi M1, 2 ; Zakeri A4 ; Akhavan Rezayat S5 ; Ramezani A2 ; Esghaei M3 ; Farahani A6
Authors
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Authors Affiliations
  1. 1. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
  5. 5. Department of Management & Health Economics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Infectious and Tropical Diseases Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran

Source: Journal of Clinical Laboratory Analysis Published:2021


Abstract

Background: Retinoblastoma is the most common primary intraocular malignancy in children less than 4 years. Retinoblastoma (RB) contains about 3%–5% of all childhood cancers. Recent studies demonstrated that interacting between RB tumor suppressor and oncoproteins of DNA tumor viruses such as human papillomavirus (HPV). The objective of the current systematic review study was to present conducted studies in the field of HPV infection and its possible role in retinoblastoma. Methods: For this systematic review, all relevant original research studies were assessed by searching in electronic databases include PubMed, Embase, Scopus, Google Scholar, and Web of Science by using relevant keywords. The study was designed based on the PRISMA criteria. All publications with English literature and original researches are considered for screening. Results: Conducted search results lead to 4070 studies. The title and abstract screening lead to 11 studies. Data extraction was performed on 8 included studies. The prevalence of the HPV was ranged from 0 to 69%, and HPV genotype 16 and 18 were the most detected types. The most used method for the detection of the viruses was PCR, and the most assessed sample was formalin-fixed, paraffin-embedded tissue blocks. Conclusion: The association between HPV and retinoblastoma is still inconsistent. The prevalence of the HPV in RB was ranged from 0 to 69%, which indicates a wide range and highlights the importance of further investigation for more accurate statistical of HPV prevalence in RB. Thus, further worldwide studies of larger sample sizes of cohorts should be investigated to clarify this uncertainty. © 2021 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC.
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