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A Systematic Review and Meta-Analysis on the Global Status of Trichomonas Vaginalis Virus in Trichomonas Vaginalis Publisher Pubmed



Bahadory S1 ; Aminizadeh S2 ; Taghipour A1 ; Bokharaeisalim F3 ; Khanaliha K4 ; Razizadeh MH3 ; Soleimani A5 ; Beikzadeh L6 ; Khatami A3
Authors
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Authors Affiliations
  1. 1. Department of Parasitology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
  2. 2. Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Virology, Faculty of Medicine, Iran University of Medical Science, Tehran, Iran
  4. 4. Research Center of Pediatric Infectious Diseases, Institute of Immunology and Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Infectious Diseases, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran
  6. 6. Department of Medical Laboratory Sciences, Faculty of Para-Medicine, Alborz University of Medical Sciences, Karaj, Iran

Source: Microbial Pathogenesis Published:2021


Abstract

Background: The small (4.5–5kbp), double-stranded Trichomonas vaginalis virus (TVV) that inhabits in the T. vaginalis parasite has been potentially associated to parasite virulence or its drug resistance. The aim of present study was to estimate the global and regional status of TVV in T. vaginalis. Methods: A systematic search was conducted for published articles between January 1990 and December 2020 by using five major databases include PubMed, Embase, Scopus, and Web of Science as well as Google scholar search engine. The random-effect model was applied for pooled prevalence of TVV, geographical distribution, and heterogeneity by comprehensive meta-analysis (V2.2, Bio stat) software. Findings: A total of 28 studies were included for final meta-analysis. The pooled prevalence of TVV was estimated at 47% (95% CI, 39.3–54.8%). With respect to WHO regions, the lowest and highest prevalence rates were reported from South-East Asia 23% (95% CI, 12–41%) and African 66% (95% CI, 25–92%), respectively. Considering the countries, the prevalence was highest in the Brazil 90% (95% CI, 73–97%) and lowest in the South Korea 14% (95% CI, 4–35%). Conclusion: The high prevalence of the parasitic virus emphasizes the need to pay attention to the behavior of the parasite, both in terms of clinical symptoms and drug resistance. Moreover, it is suggested that more studies (i.e. in vitro, in vivo, and case-control studies) should be conducted for deep understanding of this coexistence. © 2021 Elsevier Ltd
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