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Epicardial Adipose Tissue and Metabolic Syndrome: An Update Protocol for Systematic Review and Meta-Analysis Publisher Pubmed



Roever L1 ; Resende ES1 ; Diniz ALD1 ; Penhasilva N1 ; Oconnell JL1 ; Gomes PFS1 ; Zanetti HR1, 2 ; Roerverborges AS2 ; Veloso FC1 ; De Souza FR1 ; Duarte PRA1 ; Fidale TM1 ; Casellafilho A3 ; Dourado PMM3 Show All Authors
Authors
  1. Roever L1
  2. Resende ES1
  3. Diniz ALD1
  4. Penhasilva N1
  5. Oconnell JL1
  6. Gomes PFS1
  7. Zanetti HR1, 2
  8. Roerverborges AS2
  9. Veloso FC1
  10. De Souza FR1
  11. Duarte PRA1
  12. Fidale TM1
  13. Casellafilho A3
  14. Dourado PMM3
  15. Chagas ACP3, 4
  16. Alihasanalsaegh S5
  17. Reis PEO6
  18. De Melo Costa Pinto R1
  19. Oliveira GBF7
  20. Avezum A7
  21. Neto M8
  22. Duraes A8
  23. Da Silva RMFL9
  24. Grande AJ10
  25. Denardi C11
  26. Lopes RD12
  27. Nerlekar N13
  28. Alizadeh S14, 15
  29. Hernandez AV16
  30. Da Rosa MI17
  31. Biondizoccai G18
Show Affiliations
Authors Affiliations
  1. 1. Federal University of Uberlandia, Department of Clinical Research, Master Institute of Education President Antonio Carlos, IMEPAC, Araguari, Brazil
  2. 2. Department of Clinical Research, HCFMUSP, University of Sao Paulo Medical School, Brazil
  3. 3. Faculty of Medicine ABC, Department of Cardiology Santo Andre, Brazil
  4. 4. Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Department of Cardiology, Yazd, Iran
  5. 5. Department of Specialized and General Surgery, Fluminense Federal University, Rio de Janeiro, Brazil
  6. 6. Dante Pazzanese Institute of Cardiology, Department of Clinical Research, Sao Paulo, Brazil
  7. 7. Graduate Program in Medicine and Health, Department of Health and Sciences, Federal University of Bahia, Brazil
  8. 8. Federal University of Minas Gerais, Department of Cardiology MG, Brazil
  9. 9. Federal University of Mato Grosso, Department of Medicine MT, Brazil
  10. 10. FOP Unicamp, Department of Clinical Research SP, Brazil
  11. 11. Division of Cardiology, Duke University Medical Center, Department of Clinical Research, Durham, NC, United States
  12. 12. Monash Cardiovascular Research Centre and Monash Heart, Department of Cardiology, Clayton, VIC, Australia
  13. 13. Department of Medicine, Tehran University of Medical Sciences, Iran
  14. 14. University of Connecticut, Hartford Hospital Evidence-Based Practice Center, Hartford, United States
  15. 15. Department of Comparative Effectiveness and Outcomes Research Health Outcomes, CT, Criciuma, Brazil
  16. 16. Laboratory of Epidemiology, University of Extremo sul Catarinense, Criciuma, Brazil
  17. 17. Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy
  18. 18. Department of Angio Cardio Neurology, IRCCS Neuromed, Pozzilli, Italy

Source: Medicine (United States) Published:2018


Abstract

Background: The prevalence of metabolic syndrome (MetS) and MetS-related stroke is set to increase dramatically in coming decades. MetS is a complex disease that includes endothelial dysfunction, insulin resistance, diabetes, hypertension, ectopic obesity, and dyslipidaemia, and an increased risk of cardiovascular events. However, there are no systematic analyses, or wellconducted meta-analyses to evaluate the relationship between epicardial adipose tissue (EAT) and (MetS). The aim of this study is to examine this association of EAT with MetS in different ages and sex. Methods: The update systematic review, and meta-analysis will be conducted using published studies that will be identified from electronic databases (ie, PubMed, EMBASE, Web of Science, and Google Scholar. Studies that firstly, examined the association between EAT and MetS, secondly, focus on cohort, case-control, and cross-sectional studies, thirdly, were conducted among in adults aged between 40 and 70 years, fourth, provided sufficient data for calculating ORs or relative risk with a 95% CI, fifth, were published as original articles written in English or other languages, and sixth, have been published until January year 2018 will be included. Study selection, data collection, quality assessment, and statistical syntheses will be conducted based on discussions among investigators. Results: Ethics approval was not required for this study because it was based on published studies. The results and findings of this study will be submitted and published in a scientific peer-reviewed journal. This study will provide a high quality synthesis on the association of EAT and MetS. Conclusion: This systematic review will provide evidence to assess whether there is a strong association of EAT and MetS, and its components. © 2018 the Author(s). Published by Wolters Kluwer Health, Inc.
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