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Sars-Cov-2 Seroprevalence Among Health Care Workers in Major Private and Public Hospitals With Covid-19 Patient's Referral in Tehran, Iran Publisher Pubmed



Darvishian M1 ; Sharafkhah M2 ; Mohammadi Z2 ; Sadeghniiathaghighi K3 ; Abdollahi A4 ; Jafary M5 ; Talaschian M6 ; Tabarsi P7 ; Baghai P7 ; Mardani M8 ; Shayanrad A2 ; Shafighian F9 ; Markarian M10 ; Roozafzai F2 Show All Authors
Authors
  1. Darvishian M1
  2. Sharafkhah M2
  3. Mohammadi Z2
  4. Sadeghniiathaghighi K3
  5. Abdollahi A4
  6. Jafary M5
  7. Talaschian M6
  8. Tabarsi P7
  9. Baghai P7
  10. Mardani M8
  11. Shayanrad A2
  12. Shafighian F9
  13. Markarian M10
  14. Roozafzai F2
  15. Zamani M10
  16. Alvand S2
  17. Hariri S2
  18. Sadeghi A10
  19. Poustchi H2
  20. Malekzadeh R9, 10
Show Affiliations
Authors Affiliations
  1. 1. Cancer Control Research, BC Cancer Research Centre, Vancouver, BC, Canada
  2. 2. Liver and Pancreatobiliary Diseases Research Center, Shariati Hospital, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Occupational Sleep Research Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Pathology, School of Medicine, Imam Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Internal Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Clinical Tb and Epidemiology Research Center, NRITLD, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
  8. 8. Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  9. 9. Digestive Oncology Research Center, Digestive Diseases Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  10. 10. Digestive Disease Research Center, Digestive Diseases Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Frontiers in Public Health Published:2022


Abstract

Estimating the prevalence of SARS-CoV-2 antibody seropositivity among health care workers (HCWs) is crucial. In this study, the seroprevalence of anti-SARS-CoV-2 antibodies among HCWs of five hospitals of Tehran, Iran with high COVID-19 patient's referrals from April to June, 2020, was assessed. In this cross-sectional study, HCWs from three public and two private hospitals, selected randomly as a pilot, were included. Participants were asked questions on their demographic characteristics, medical history, hospital role, and usage of personal protective equipment (PPE). Iran FDA-approved SARS-CoV-2 ELISA kits were used to detect IgG and IgM antibodies in blood samples. The seroprevalence was estimated on the basis of ELISA test results and adjusted for test performance. Among the 2,065 participants, 1,825 (88.4%) and 240 (11.6%) HCWs were recruited from public and private hospitals, respectively. A total of 340 HCWs were tested positive for SARS-CoV-2-specific IgG or IgM antibodies, and 17.9% of seropositive individuals were asymptomatic. The overall test performance-adjusted seroprevalence estimate among HCWs was 22.6 (95% CI: 20.2–25.1), and PPE usage was significantly higher among HCWs of public vs. private hospitals (66.5 vs. 20.0%). This study found that seroprevalence of SARS-CoV-2 among HCWs was higher in private hospitals (37.0%; 95% CI: 28.6–46.2) than public hospitals (20.7%; 95% CI: 18.2–23.3), and also highest among assistant nurses and nurses, and lowest among janitor or superintendent categories. The PPE usage was especially suboptimal among HCWs in private hospitals. Continued effort in access to adequate PPE and regular screening of hospital staff for detecting asymptomatic personnel, especially during the upcoming wave of infection, are warranted. Copyright © 2022 Darvishian, Sharafkhah, Mohammadi, Sadeghniiat-haghighi, Abdollahi, Jafary, Talaschian, Tabarsi, Baghai, Mardani, Shayanrad, Shafighian, Markarian, Roozafzai, Zamani, Alvand, Hariri, Sadeghi, Poustchi and Malekzadeh.
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