Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Antibody Rapid Test Results in Emergency Medical Services Personnel During Covid-19 Pandemic; a Cross Sectional Study Publisher



Saberian P1, 2 ; Mireskandari SM3 ; Baratloo A1, 4 ; Hasanisharamin P5 ; Babaniamansour S6 ; Aliniagerdroudbari E7 ; Jamshididana M5
Authors
Show Affiliations
Authors Affiliations
  1. 1. Pre-Hospital and Hospital Emergency Research Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Anesthesiology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Anesthesiology and Critical Care, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Emergency Medicine, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Tehran Emergency Medical Service Center, Tehran, Iran
  6. 6. School of Medicine, Islamic Azad University of Medical Sciences, Tehran, Iran
  7. 7. School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Archives of Academic Emergency Medicine Published:2020


Abstract

Introduction: Like other infectious diseases, it is expected that COVID-19 will mostly end with the development of neutralizing antibody immunity. This study aimed to evaluate the value of COVID-19 antibody rapid test assessment in emergency medical services (EMS) personnel. Methods: This cross-sectional study was conducted in Tehran, Iran from 20th March until 20th May 2020. The results of chest computed tomography (CT) scan, and antibody rapid test were compared in EMS personnel with confirmed COVID-19, as well as symptomatic and asymptomatic ones who had exposure to a probable/confirmed COVID-19 teammate. In symptomatic or asymptomatic individuals who were only IgM-positive, chest CT scan or RT-PCR was recommended. Results: A total of 243 EMS personnel with the mean age of 36.14±8.70 (range 21 to 59) years took part in this study (87.7% were males). Most of the participants (73.3%) had history of exposure. One hundred sixty-three EMS personnel were tested using either RT-PCR test or chest CT-scan or both, and 78 (47.9%) of them had at least one positive result. Among the participants who had undergone chest CT-scan and/or RT-PCR test (n=163), 78 had positive chest CT-scan and/or RT-PCR test; of these, 18 individuals had negative results for IgM and IgG. The rate of positive IgM and IgG in participants with positive chest CT-scan was 1.6 or 1.3 times more than those with negative chest CT-scan, respectively (p < 0.05). The percentage of positive results for both IgM and IgG in participants having positive RT-PCR test was 1.7 times more than those having negative RT-PCR test (p < 0.05). Conclusion: Rapid antibody test could help in diagnosis of COVID-19 in asymptomatic or symptomatic EMS personnel who did not undergo RT-PCR test or the test was reported as negative. However, its sensitivity could be enhanced through use along with other diagnostic methods. © 2020. All rights reserved.
Related Docs
1. The Contributory Role of Lymphocyte Subsets, Pathophysiology of Lymphopenia and Its Implication As Prognostic and Therapeutic Opportunity in Covid-19, International Immunopharmacology (2021)
2. Serological and Molecular Tests for Covid-19: A Recent Update, Iranian Journal of Immunology (2021)
3. Molecular Signaling Pathways, Pathophysiological Features in Various Organs, and Treatment Strategies in Sars-Cov2 Infection, Acta Histochemica (2022)
4. Anti-Ige Monoclonal Antibodies As Potential Treatment in Covid-19, Immunopharmacology and Immunotoxicology (2021)
5. Comparison of Immune Response Between Sars, Mers, and Covid-19 Infection, Perspective on Vaccine Design and Development, BioMed Research International (2021)
6. Covid-19: Significance of Antibodies, Human Antibodies (2020)
7. Neutrophil to Lymphocyte Ratio and C-Reactive Protein Level As Prognostic Markers in Mild Versus Severe Covid-19 Patients, Gastroenterology and Hepatology from Bed to Bench (2020)
8. Immune Cell Profiling and Antibody Responses in Patients With Covid-19, BMC Infectious Diseases (2021)
Experts (# of related papers)
View all Related Experts
Nima Rezaei (1)
Ali Akbar Amirzargar (1)