Fabrication and Study of Curcumin Loaded Nanoparticles Based on Folate-Chitosan for Breast Cancer Therapy Application

Fabrication and Study of Curcumin Loaded Nanoparticles Based on Folate-Chitosan for Breast Cancer Therapy Application Publisher Pubmed

Esfandiarpourboroujeni S¹ ; Bagherikhoulenjani S¹ ; Mirzadeh H¹ ; Amanpour S²

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1. Department of Polymer and Color Engineering, Amirkabir University of Technology, 424, Hafez St., P.O. Box: 15875-4413, Tehran, Iran
2. Cancer Biology Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran

Source: Carbohydrate Polymers Published:2017

Abstract

Purpose of this article is developing novel, inexpensive curcumin loaded chitosan nanoparticles with targeting ability. Curcumin loaded folate-modified-chitosan-nanoparticles (NPs) have been synthesized and fabricated via self-assembling process. Chemical structures of modified chains, nanoparticle size in dry and wet state, zeta potential, morphology of NPs, physical state of curcumin in NPs, drug release profile and cytotoxicity of NPs were investigated by FTIR, FE-SEM, DLS and XRD, UV–vis spectrophotometer, and MTT assay against L929 and MCF7 cell lines, respectively. Results show nanoparticle size in dry state varied in range of 119–127 nm and curcumin was loaded into nanoparticles with 96.47% efficacy. Drug release studies showed by decreasing pH of release medium from 7.4 to 5, release rate of curcumin from NPs increased, which shows pH responsive capacity of folate-modified chitosan nanoparticles. Cell viability studies confirmed that curcumin loaded NPs have good potential as a drug delivery system for breast cancer therapy. © 2017 Elsevier Ltd

2. Curcumin: Footprints on Cardiac Tissue Engineering, Expert Opinion on Biological Therapy (2019)

3. Plant Protein-Based Hydrophobic Fine and Ultrafine Carrier Particles in Drug Delivery Systems, Critical Reviews in Biotechnology (2018)

4. Ph-Sensitive Stimulus-Responsive Nanocarriers for Targeted Delivery of Therapeutic Agents, Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology (2016)

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Style	Citing Format
MLA	Esfandiarpourboroujeni S, et al.. "Fabrication and Study of Curcumin Loaded Nanoparticles Based on Folate-Chitosan for Breast Cancer Therapy Application." Carbohydrate Polymers, vol. 168, no. , 2017, pp. 14-21.
APA	Esfandiarpourboroujeni S, Bagherikhoulenjani S, Mirzadeh H, Amanpour S (2017). Fabrication and Study of Curcumin Loaded Nanoparticles Based on Folate-Chitosan for Breast Cancer Therapy Application. Carbohydrate Polymers, 168(), 14-21.
Chicago	Esfandiarpourboroujeni S, Bagherikhoulenjani S, Mirzadeh H, Amanpour S. "Fabrication and Study of Curcumin Loaded Nanoparticles Based on Folate-Chitosan for Breast Cancer Therapy Application." Carbohydrate Polymers 168, no. (2017): 14-21.
Harvard	Esfandiarpourboroujeni S et al. (2017) 'Fabrication and Study of Curcumin Loaded Nanoparticles Based on Folate-Chitosan for Breast Cancer Therapy Application', Carbohydrate Polymers, 168(), pp. 14-21.
Vancouver	Esfandiarpourboroujeni S, Bagherikhoulenjani S, Mirzadeh H, Amanpour S. Fabrication and Study of Curcumin Loaded Nanoparticles Based on Folate-Chitosan for Breast Cancer Therapy Application. Carbohydrate Polymers. 2017;168():14-21.
BibTex	@article{ author = {Esfandiarpourboroujeni S and Bagherikhoulenjani S and Mirzadeh H and Amanpour S}, title = {Fabrication and Study of Curcumin Loaded Nanoparticles Based on Folate-Chitosan for Breast Cancer Therapy Application}, journal = {Carbohydrate Polymers}, volume = {168}, number = {}, pages = {14-21}, year = {2017} }
RIS	TY - JOUR AU - Esfandiarpourboroujeni S AU - Bagherikhoulenjani S AU - Mirzadeh H AU - Amanpour S TI - Fabrication and Study of Curcumin Loaded Nanoparticles Based on Folate-Chitosan for Breast Cancer Therapy Application JO - Carbohydrate Polymers VL - 168 IS - SP - 14 EP - 21 PY - 2017 ER -

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