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The Synthesis and Characterization of Double Nanoemulsion for Targeted Co-Delivery of 5-Fluorouracil and Curcumin Using Ph-Sensitive Agarose/Chitosan Nanocarrier Publisher



Pourmadadi M1 ; Ahmadi M1 ; Abdouss M2 ; Yazdian F3 ; Rashedi H1 ; Navaeinigjeh M4, 5 ; Hesari Y1
Authors
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Authors Affiliations
  1. 1. School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran
  2. 2. Department of Chemistry, Amirkabir University of Technology, Tehran, Iran
  3. 3. Department of Life Science Engineering, Faculty of New Science and Technology, University of Tehran, Iran
  4. 4. Pharmaceutical Sciences Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences (TUMS), Tehran, Iran
  5. 5. Department of Pharmaceutical Biomaterials and Medical Biomaterials Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences (TUMS), Tehran, Iran

Source: Journal of Drug Delivery Science and Technology Published:2022


Abstract

Due to the dangerous side effects of chemotherapy, advanced methods for curing cancer, such as drug delivery, have attracted much attention because of their high efficacies. Using a green synthesizing method, we prepared a double nano-emulsion agarose/chitosan nanocomposite as the carrier of this work to adjust stability and hydrogel releasing. Curcumin, 5-fluorouracil, and curcumin/5-fluorouracil were loaded into the nano-carrier, and the synthesized systems were characterized by XRD, FESEM, FTIR, DLS, and zeta potential analysis. Loading efficacy and entrapment efficacy of curcumin in the agarose/chitosan nanocomposite were 85.6% and 79.2%, respectively. Drug release profiles proved the pH sensitivity of the nanocomposite by providing a 24–44% difference in drug cumulative release rate between the tumor-simulated and the normal cell-simulated buffers. Also, MTT and the flow cytometry analysis showed the biocompatibility of the carrier and the effect of using both drugs, as a co-delivery system, on cytotoxicity against the MCF-7 cells. These results demonstrate the potential of the chitosan/agarose@curcumin/5-fluorouracil to be a candidate for the targeted treatment of cancer cells. © 2021 Elsevier B.V.
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