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Comparative and Phylogenetic Analysis of Epstein-Barr Virus Isolates in Gastric Cancer and Chronic Gastritis Patients in Iran Publisher



Sarshari B1, 2 ; Zarehkhoshchehreh R1, 3 ; Tavallaei M4 ; Rajabnia M5 ; Norooz MT6 ; Mohebbi SR7 ; Ravanshad M1
Authors
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Authors Affiliations
  1. 1. Department of Medical Virology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
  2. 2. Iranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High-Risk Behaviors, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Food & Drug Administration, Iran Ministry of Health & Medical Education, Tehran, Iran
  4. 4. Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran
  6. 6. Critical Care & Quality Improvement Research Center, Shahid Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  7. 7. Basic & Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology & Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Future Virology Published:2023


Abstract

Aim: To investigate the correlation between Epstein-Barr virus (EBV) variants and EBV-associated gastric cancer (EBVaGC) in Iran. Materials & methods: Biopsies from 21 gastric cancer (4 positive EBER-ISH [EBVaGC] and 17 negative EBER-ISH) and 11 gastritis patients were analyzed using nested PCR and sequencing. Results: Genotype 1 (75%) was the predominant EBV genotype. The P-thr variant was the most common in all groups (positive EBER-ISH 75%, negative EBER-ISH 76.4%, and gastritis 81.8%), followed by P-ala. Additionally, the predominant LMP1 strain in all groups was Med. Sequencing analysis revealed a strong correlation between the P-thr and type 1. Conclusion: Since no preferential correlations were observed between distinct EBV variants and the study groups, these results might indicate geographic polymorphisms. © 2024 Expert Publishing Medicine Ltd trading as Taylor & Francis.
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