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Molecular Investigation of Human Cytomegalovirus and Epstein-Barr Virus in Glioblastoma Brain Tumor: A Case-Control Study in Iran Publisher Pubmed



Ghaffari H1 ; Tavakoli A2 ; Faranoush M3 ; Naderi A4 ; Kiani SJ5 ; Sadeghipour A6 ; Javanmard D7 ; Farahmand M8 ; Ghorbani S5 ; Sedaghati F9 ; Monavari SH5
Authors
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Authors Affiliations
  1. 1. Department of Bacteriology and Virology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran
  2. 2. Research Center of Pediatric Infectious Diseases, Institute of Immunology and Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Pediatric Growth and Development Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran
  4. 4. Mahak Pediatric Cancer Treatment and Research Center, Tehran, Iran
  5. 5. Department of Medical Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Pathology, Hazrat-e-Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
  7. 7. Infectious Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran
  8. 8. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  9. 9. Department of Pathology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran

Source: Iranian Biomedical Journal Published:2021


Abstract

Background: Glioblastoma multiforme is the most invasive and lethal form of brain cancer with unclear etiology. Our study aimed to investigate the molecular prevalence of HCMV and EBV infections in patients with GBM. Methods: This case-control study was conducted on 42 FFPE brain tumor samples from GBM patients and 42 brain autopsies from subjects without neurological disorders. The presence of EBV and HCMV DNA was determined, using PCR and nested-PCR assays, respectively. Results: HCMV DNA was detected in 3 out of 42 (7.1%) of GBM samples and was absent from the control group (p = 0.07). Importantly, EBV DNA was detected in 9 out of 42 (21.4%) brain tissue specimens of GBM subjects, but again in none of the control group (p = 0.001). Conclusion: Our findings indicate that infection with EBV is associated with GBM. DOI: 10.52547/ibj.25.6.426. © 2021, Pasteur Institute of Iran. All rights reserved.
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