Effect of Bucladesine, Pentoxifylline, and H-89 As Cyclic Adenosine Monophosphate Analog, Phosphodiesterase, and Protein Kinase a Inhibitor on Acute Pain

Effect of Bucladesine, Pentoxifylline, and H-89 As Cyclic Adenosine Monophosphate Analog, Phosphodiesterase, and Protein Kinase a Inhibitor on Acute Pain Publisher Pubmed

Salehi F¹ ; Hosseinizare MS^{1, 2} ; Aghajani H³ ; Seyedi SY¹ ; Hosseinizare MS^{1, 2} ; Sharifzadeh M¹

Show Affiliations

1. Department of Pharmacology and Toxicology, Pharmaceutical Science Research Center, Tehran University of Medical Science, PO Box 14155-6451, Tehran, Iran
2. Department of Biology and Biochemistry, University of Houston, Houston, 77204, TX, United States
3. Department of Biomedical Engineering, University of Houston, Houston, 77204, TX, United States

Source: Fundamental and Clinical Pharmacology Published:2017

Abstract

The aim of this study was to determine the effects of cyclic adenosine monophosphate (cAMP) and its dependent pathway on thermal nociception in a mouse model of acute pain. Here, we studied the effect of H-89 (protein kinase A inhibitor), bucladesine (Db-cAMP) (membrane-permeable analog of cAMP), and pentoxifylline (PTX; nonspecific phosphodiesterase (PDE) inhibitor) on pain sensation. Different doses of H-89 (0.05, 0.1, and 0.5 mg/100 g), PTX (5, 10, and 20 mg/100 g), and Db-cAMP (50, 100, and 300 nm/mouse) were administered intraperitoneally (I.p.) 15 min before a tail-flick test. In combination groups, we injected the first and the second compounds 30 and 15 min before the tail-flick test, respectively. I.p. administration of H-89 and PTX significantly decreased the thermal-induced pain sensation in their low applied doses. Db-cAMP, however, decreased the pain sensation in a dose-dependent manner. The highest applied dose of H-89 (0.5 mg/100 g) attenuated the antinociceptive effect of Db-cAMP in doses of 50 and 100 nm/mouse. Surprisingly, Db-cAMP decreased the antinociceptive effect of the lowest dose of H-89 (0.05 mg/100 g). All applied doses of PTX reduced the effect of 0.05 mg/100 g H-89 on pain sensation; however, the highest dose of H-89 compromised the antinociceptive effect of 20 mg/100 g dose of PTX. Co-administration of Db-cAMP and PTX increased the antinociceptive effect of each compound on thermal-induced pain. In conclusion, PTX, H-89, and Db-cAMP affect the thermal-induced pain by probably interacting with intracellular cAMP and cGMP signaling pathways and cyclic nucleotide-dependent protein kinases. © 2017 Societe Francaise de Pharmacologie et de Therapeutique

Related Docs

View other Related Docs

1. Protective Effect of a Camp Analogue on Behavioral Deficits and Neuropathological Changes in Cuprizone Model of Demyelination, Molecular Neurobiology (2015)

2. Bucladesine Attenuates Spatial Learning and Hippocampal Mitochondrial Impairments Induced by 3, 4-Methylenedioxymethamphetamine (Mdma), Neurotoxicity Research (2020)

3. Protective Effects of Aminoguanidine Against Sodium Metavanadate-Induced Spatial Memory Retention Impairment in Morris Water Maze, Pharmaceutical Sciences (2019)

4. Reduction of Autophagy Markers Mediated Protective Effects of Jnk Inhibitor and Bucladesine on Memory Deficit Induced by Aβ in Rats, Naunyn-Schmiedeberg's Archives of Pharmacology (2016)

5. Interactive Involvement of Hippocampal Camp/Pka and Cyclooxygenase-2 Signaling Pathways in Spatial Learning in the Morris Water Maze, Folia Neuropathologica (2018)

6. Modafinil Prevents Testosterone - Provoked Spatial Learning Impairments in Morris Water Maze and Increases the Quantity of Brdu-Positive Cells in Dentate Gyrus in Male Rats, Farmacia (2017)

7. The Effect of Preoperative Pentoxifylline on Postoperative Pain and Development of Secondary Hyperalgesia in Patients Undergoing Laparoscopic Appendectomy: A Randomized, Double-Blind, Placebo-Controlled Trial Study, Pain Practice (2021)

8. A Camp Analog Attenuates Beta-Amyloid (1–42)-Induced Mitochondrial Dysfunction and Spatial Learning and Memory Deficits, Brain Research Bulletin (2018)

Experts (# of related papers)

View all Related Experts

Mohammad Sharifzadeh (10)

Seyed Morteza Karimian (1)

Style	Citing Format
MLA	Salehi F, et al.. "Effect of Bucladesine, Pentoxifylline, and H-89 As Cyclic Adenosine Monophosphate Analog, Phosphodiesterase, and Protein Kinase a Inhibitor on Acute Pain." Fundamental and Clinical Pharmacology, vol. 31, no. 4, 2017, pp. 411-419.
APA	Salehi F, Hosseinizare MS, Aghajani H, Seyedi SY, Hosseinizare MS, Sharifzadeh M (2017). Effect of Bucladesine, Pentoxifylline, and H-89 As Cyclic Adenosine Monophosphate Analog, Phosphodiesterase, and Protein Kinase a Inhibitor on Acute Pain. Fundamental and Clinical Pharmacology, 31(4), 411-419.
Chicago	Salehi F, Hosseinizare MS, Aghajani H, Seyedi SY, Hosseinizare MS, Sharifzadeh M. "Effect of Bucladesine, Pentoxifylline, and H-89 As Cyclic Adenosine Monophosphate Analog, Phosphodiesterase, and Protein Kinase a Inhibitor on Acute Pain." Fundamental and Clinical Pharmacology 31, no. 4 (2017): 411-419.
Harvard	Salehi F et al. (2017) 'Effect of Bucladesine, Pentoxifylline, and H-89 As Cyclic Adenosine Monophosphate Analog, Phosphodiesterase, and Protein Kinase a Inhibitor on Acute Pain', Fundamental and Clinical Pharmacology, 31(4), pp. 411-419.
Vancouver	Salehi F, Hosseinizare MS, Aghajani H, Seyedi SY, Hosseinizare MS, Sharifzadeh M. Effect of Bucladesine, Pentoxifylline, and H-89 As Cyclic Adenosine Monophosphate Analog, Phosphodiesterase, and Protein Kinase a Inhibitor on Acute Pain. Fundamental and Clinical Pharmacology. 2017;31(4):411-419.
BibTex	@article{ author = {Salehi F and Hosseinizare MS and Aghajani H and Seyedi SY and Hosseinizare MS and Sharifzadeh M}, title = {Effect of Bucladesine, Pentoxifylline, and H-89 As Cyclic Adenosine Monophosphate Analog, Phosphodiesterase, and Protein Kinase a Inhibitor on Acute Pain}, journal = {Fundamental and Clinical Pharmacology}, volume = {31}, number = {4}, pages = {411-419}, year = {2017} }
RIS	TY - JOUR AU - Salehi F AU - Hosseinizare MS AU - Aghajani H AU - Seyedi SY AU - Hosseinizare MS AU - Sharifzadeh M TI - Effect of Bucladesine, Pentoxifylline, and H-89 As Cyclic Adenosine Monophosphate Analog, Phosphodiesterase, and Protein Kinase a Inhibitor on Acute Pain JO - Fundamental and Clinical Pharmacology VL - 31 IS - 4 SP - 411 EP - 419 PY - 2017 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract