Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Targeting Neuroinflammation by Intranasal Delivery of Nanoparticles in Neurological Diseases: A Comprehensive Review Publisher Pubmed



Moradi F1 ; Dashti N2, 3
Authors
Show Affiliations
Authors Affiliations
  1. 1. School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
  2. 2. Department of Clinical Laboratory Sciences, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Office of Vice-Chancellor for Global Strategies and International Affairs, Tehran University of Medical Sciences, Number 21, Dameshgh St., Vali-e Asr Ave., Tehran, 1416753955, Iran

Source: Naunyn-Schmiedeberg's Archives of Pharmacology Published:2022


Abstract

Neuroinflammation (NIF) plays an essential role in the pathology of neurological disorders like Parkinson’s disease, Alzheimer’s disease, multiple sclerosis, and epilepsy. Despite progress in the drug discovery and development of new drugs, drug delivery to the central nervous system (CNS) still represents the challenge due to the presence of the blood–brain barrier (BBB). Targeting NIF may require an adequate amount of drug to cross the BBB. Recently, the intranasal (IN) drug administration has attracted increasing attention as a reliable method to cross the BBB and treat neurological disorders. On the other hand, using optimized nanoparticles may improve the IN delivery limitations, increase the mucoadhesive properties, and prevent drug degradation. NPs can carry and deliver drugs to the CNS by bypassing the BBB. In this review, we described briefly the NIF as a pathologic feature of CNS diseases. The potential treatment possibilities with IN transfer of NP-loaded drugs will enhance the establishment of more efficient nanoformulations and delivery systems. © 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Related Docs
View other Related Docs
1. Recent Progress in the Intranasal Plga-Based Drug Delivery for Neurodegenerative Diseases Treatment, Iranian Journal of Basic Medical Sciences (2023)
2. Neuroinflammation and Proinflammatory Cytokines in Epileptogenesis, Molecular Neurobiology (2022)
3. Nanoparticles in Combating Neuronal Dysregulated Signaling Pathways: Recent Approaches to the Nanoformulations of Phytochemicals and Synthetic Drugs Against Neurodegenerative Diseases, International Journal of Nanomedicine (2022)
4. Application of Nanomedicine for Crossing the Blood–Brain Barrier: Theranostic Opportunities in Multiple Sclerosis, Journal of Immunotoxicology (2016)
5. Emerging Novel Approaches for the Enhanced Delivery of Natural Products for the Management of Neurodegenerative Diseases, Journal of Molecular Neuroscience (2022)
6. Intranasal Delivery of Sunitinib: A New Therapeutic Approach for Targeting Angiogenesis of Glioblastoma, Toxicology and Applied Pharmacology (2023)
7. Recent Developments of Nanostructures for the Ocular Delivery of Natural Compounds, Frontiers in Chemistry (2022)
8. Nanobased Cns Delivery Systems, Nanobiomaterials: Applications in Drug Delivery (2018)
Experts (# of related papers)
View all Related Experts
Nima Rezaei (3)
Somayeh Handali (3)
Other Related Docs
9. General Justification in Terms of Effectiveness and Toxicities for the Use of Nanocarriers, Journal of Nanoparticle Research (2023)
10. Unveiling the Theranostic Potential of Spions in Alzheimer's Disease Management, Journal of Psychiatric Research (2024)
11. Liposomes: Structure, Biomedical Applications, and Stability Parameters With Emphasis on Cholesterol, Frontiers in Bioengineering and Biotechnology (2021)
12. What We Need to Know About Liposomes As Drug Nanocarriers: An Updated Review, Advanced Pharmaceutical Bulletin (2023)
13. Emerging Advances of Nanotechnology in Drug and Vaccine Delivery Against Viral Associated Respiratory Infectious Diseases (Varid), International Journal of Molecular Sciences (2021)
14. Emerging Innovations in Vincristine-Encapsulated Nanoparticles: Pioneering a New Era in Oncological Therapeutics, Journal of Drug Delivery Science and Technology (2024)
15. Nanoformulations of Herbal Extracts in Treatment of Neurodegenerative Disorders, Frontiers in Bioengineering and Biotechnology (2020)
16. The Use of Carbon Quantum Dot As Alternative of Stannous Chloride Application in Radiopharmaceutical Kits, Contrast Media and Molecular Imaging (2020)
17. Intranasal Insulin Improves the Structure–Function of the Brain Mitochondrial Atp–Sensitive Ca2+ Activated Potassium Channel and Respiratory Chain Activities Under Diabetic Conditions, Biochimica et Biophysica Acta - Molecular Basis of Disease (2021)
18. The Biomedical Significance of Multifunctional Nanobiomaterials: The Key Components for Site-Specific Delivery of Therapeutics, Life Sciences (2021)
19. Gadoterate Meglumine - Anionic Linear Globular Dendrimer Second Generation: A Novel Nano Sized Theranostic Contrast Agent, Nanomedicine Journal (2021)
20. Nanoliposome Encapsulated Anesthetics for Local Anesthesia Application, Biomedicine and Pharmacotherapy (2017)
21. Extracellular Vesicles-Based Drug Delivery Systems: A New Challenge and the Exemplum of Malignant Pleural Mesothelioma, International Journal of Molecular Sciences (2020)
22. Does Pharmacodynamics of Drugs Change After Presenting Them As Na-Noparticles Like Their Pharmacokinetics?, Current Drug Targets (2020)
23. Mesenchymal Stem Cells (Mscs) and Msc-Derived Exosomes in Animal Models of Central Nervous System Diseases: Targeting the Nlrp3 Inflammasome, IUBMB Life (2023)
24. Potential Application of Liposomal Nanodevices for Non-Cancer Diseases: An Update on Design, Characterization and Biopharmaceutical Evaluation, Advances in Colloid and Interface Science (2020)
25. Novel Therapeutic Strategies for Alzheimer's Disease: Implications From Cell-Based Therapy and Nanotherapy, Nanomedicine: Nanotechnology# Biology# and Medicine (2020)
26. Nanoparticles: Novel Vehicles in Treatment of Glioblastoma, Biomedicine and Pharmacotherapy (2016)
27. Biomedical Applications of Intelligent Nanomaterials, Intelligent Nanomaterials: Second Edition (2016)
28. Delivery Systems for Leishmania Vaccine Development, Expert Review of Vaccines (2016)
29. Interlink Between Improved Formulations, Inhibitory Concentrations and Cell Death Mechanism Investigations of Cytotoxic Drugs: What Really Matters?, Journal of Controlled Release (2020)
30. Peptide Acylation in Aliphatic Polyesters: A Review of Mechanisms and Inhibition Strategies, Pharmaceutical Research (2024)
31. Sustained Delivery of Olanzapine From Sunflower Oil-Based Polyol-Urethane Nanoparticles Synthesised Through a Cyclic Carbonate Ring-Opening Reaction, IET Nanobiotechnology (2019)
32. Nanovehicle-Based Small Interfering Rna (Sirna) Delivery for Therapeutic Purposes: A New Molecular Approach in Pharmacogenomics, Current Clinical Pharmacology (2018)
33. Neuroinflammation As a Potential Therapeutic Target in Neuroimmunological Diseases, Translational Neuroimmunology: Neuroinflammation: Volume 7 (2023)
34. Recent Advances on the Application of Nanobiomimetic Structures As Drug Delivery Systems, Journal of Drug Delivery Science and Technology (2024)
35. Polymeric Nanoparticles for Dna Vaccine-Based Cancer Immunotherapy: A Review, Biotechnology Letters (2023)
36. Nanomedicine in the Treatment of Alzheimer’S Disease: Bypassing the Blood-Brain Barrier With Cutting-Edge Nanotechnology, Neurological Sciences (2025)
37. The Dialogue Between Neuroinflammation and Adult Neurogenesis: Mechanisms Involved and Alterations in Neurological Diseases, Molecular Neurobiology (2023)
38. Nexus Between in Silico and in Vivo Models to Enhance Clinical Translation of Nanomedicine, Nano Today (2021)
39. A Review of Chitosan-Based Nanocarriers As Drug Delivery Systems for Brain Diseases: Critical Challenges, Outlooks and Promises, International Journal of Biological Macromolecules (2024)
40. Cd133-Functionalized Gold Nanoparticles As a Carrier Platform for Telaglenastat (Cb-839) Against Tumor Stem Cells, International Journal of Molecular Sciences (2022)
41. Heart Targeted Nanoliposomal/Nanoparticles Drug Delivery: An Updated Review, Biomedicine and Pharmacotherapy (2017)
42. One-Step Synthesis of Silver Nanostructures Using Heracleum Persicum Fruit Extract, Their Cytotoxic Activity, Anti-Cancer and Anti-Oxidant Activities, Micro and Nano Letters (2023)
43. Super Magnetic Niosomal Nanocarrier As a New Approach for Treatment of Breast Cancer: A Case Study on Sk-Br-3 and Mda-Mb-231 Cell Lines, International Journal of Molecular Sciences (2021)
44. Effect of Metformin on Epidermal Neural Crest Stem Cells and Their Potential Application in Ameliorating Paclitaxel-Induced Neurotoxicity Phenotype, Stem Cell Reviews and Reports (2024)