Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Emerging Novel Approaches for the Enhanced Delivery of Natural Products for the Management of Neurodegenerative Diseases Publisher Pubmed



Bandiwadekar A1 ; Jose J1 ; Khayatkashani M2 ; Habtemariam S3 ; Khayat Kashani HR4 ; Nabavi SM5
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Pharmaceutics, NGSM Institute of Pharmaceutical Sciences (NGSMIPS), Nitte (Deemed To Be University), Karnataka, Mangalore, 575018, India
  2. 2. School of Iranian Traditional Medicine, Tehran University of Medical Sciences, Tehran, 14155-6559, Iran
  3. 3. Pharmacognosy Research Laboratories and Herbal Analysis Services, University of Greenwich, Central Avenue, Chatham-Maritime, United Kingdom
  4. 4. Department of Neurosurgery, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, 1617763141, Iran
  5. 5. Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

Source: Journal of Molecular Neuroscience Published:2022


Abstract

Neurodegenerative diseases (NDs) such as Alzheimer’s disease, Parkinson’s disease, Huntington disease, amyotrophic lateral sclerosis, and prion disease affect any part of the brain. The complete mechanism of ND is unknown, but there are some molecular mechanism and chemical process. Natural compounds have better compatibility with the human body along with lesser side effects. Moreover, several studies showed that various natural compounds have significant neuroprotective, potent antioxidant, and anti-inflammatory properties, which are effective for treating the different type of ND. In ND, natural compounds act by various mechanisms such as preventing the generation of reactive oxygen species (ROS), eliminating destructed biomolecules before their accumulation affects cell metabolism, and improving the disease conditions. But due to the presence of the blood–brain barrier (BBB) layer and unfavorable pharmacokinetic properties of natural compounds, their delivery into the brain is limited. To minimize this problem and enhance drug delivery into the brain with an effective therapeutic dose, there is a need to develop a practical novel approach. The various studies showed that nanoformulations and microneedles (MN) containing natural compounds such as quercetin, curcumin, resveratrol, chrysin, piperine, ferulic acid, huperzine A, berberine, baicalein, hesperetin, and retinoic acid effectively improved many ND. In this review, the effect of such natural drug-loaded nanoformulation and MN patches on ND management is discussed, along with their merits and demerits. This review aims to introduce different novel approaches for enhancing natural drug delivery into the brain to manage various neurodegenerative diseases. © 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Related Docs
View other Related Docs
1. Nanoformulations of Herbal Extracts in Treatment of Neurodegenerative Disorders, Frontiers in Bioengineering and Biotechnology (2020)
2. Nanoformulated Herbal Bioactives for the Treatment of Neurodegenerative Disorders, Herbal Bioactive-Based Drug Delivery Systems: Challenges and Opportunities (2022)
3. Nanoparticles in Combating Neuronal Dysregulated Signaling Pathways: Recent Approaches to the Nanoformulations of Phytochemicals and Synthetic Drugs Against Neurodegenerative Diseases, International Journal of Nanomedicine (2022)
4. Novel Therapeutic Strategies for Alzheimer's Disease: Implications From Cell-Based Therapy and Nanotherapy, Nanomedicine: Nanotechnology# Biology# and Medicine (2020)
5. The Synthesis, Application and Therapeutic Perspectives of Medicinal Plants-Based Solid Lipid Nanoparticles: A Comprehensive Review, Advances in Traditional Medicine (2025)
6. Improvement of Memory Deficits in the Rat Model of Alzheimer's Disease by Erythropoietin-Loaded Solid Lipid Nanoparticles, Neurobiology of Learning and Memory (2019)
7. Engineered Solid Lipid Nanoparticles and Nanostructured Lipid Carriers As New Generations of Blood-Brain Barrier Transmitters, ACS Chemical Neuroscience (2021)
8. Brain Delivery of Curcumin Using Solid Lipid Nanoparticles and Nanostructured Lipid Carriers: Preparation, Optimization, and Pharmacokinetic Evaluation, ACS Chemical Neuroscience (2019)
Experts (# of related papers)
View all Related Experts
Fatemeh Atyabi (3)
Rassoul Dinarvand (3)
Other Related Docs
9. Neuroprotective Potential of Curcumin-Loaded Nanostructured Lipid Carrier in an Animal Model of Alzheimer's Disease: Behavioral and Biochemical Evidence, Journal of Alzheimer's Disease (2019)
10. Emerging Stem Cell Therapy and Tissue Engineering-Based Approaches in Neurodegenerative Diseases, Handbook of Stem Cell Applications (2024)
11. Nanoencapsulation: A Promising Strategy for Biomedical Applications of Ferulic Acid, Biomedical Reviews (2017)
12. Atopic Dermatitis Treatment: A Comprehensive Review of Conventional and Novel Bioengineered Approaches, International Journal of Biological Macromolecules (2024)
13. Long-Term Vaccine Delivery and Immunological Responses Using Biodegradable Polymer-Based Carriers, ACS Applied Bio Materials (2022)
14. Targeting Neuroinflammation by Intranasal Delivery of Nanoparticles in Neurological Diseases: A Comprehensive Review, Naunyn-Schmiedeberg's Archives of Pharmacology (2022)
15. Vip-Loaded Plga As an Anti-Asthma Nanodrug Candidate, Comparative Clinical Pathology (2016)
16. In-Vitro and In-Vivo Comparison of Rsag1-Loaded Plga Prepared by Encapsulation and Adsorption Methods As an Efficient Vaccine Against Toxoplasma Gondii”, Journal of Drug Delivery Science and Technology (2020)
17. Targeting Erk Signaling Pathway by Polyphenols As Novel Therapeutic Strategy for Neurodegeneration, Food and Chemical Toxicology (2018)
18. Integration of Polysaccharide Electrospun Nanofibers With Microneedle Arrays Promotes Wound Regeneration: A Review, International Journal of Biological Macromolecules (2024)
19. Nanomedicine in the Treatment of Alzheimer’S Disease: Bypassing the Blood-Brain Barrier With Cutting-Edge Nanotechnology, Neurological Sciences (2025)
20. Ignoring the Modeling Approaches: Towards the Shadowy Paths in Nanomedicine, Journal of Controlled Release (2018)
21. Stem Cells and Natural Agents in the Management of Neurodegenerative Diseases: A New Approach, Neurochemical Research (2023)
22. Anti-Rheumatic Activity of Topical Nanoemulsion Containing Bee Venom in Rats, European Journal of Pharmaceutics and Biopharmaceutics (2022)
23. Nuclear Factor-Kappa B (Nf-Κb) in Pathophysiology of Parkinson Disease: Diverse Patterns and Mechanisms Contributing to Neurodegeneration, European Journal of Neuroscience (2021)
24. Preparation of Paclitaxel and Etoposide Co-Loaded Mpeg-Plga Nanoparticles: An Investigation With Artificial Neural Network, Journal of Pharmaceutical Innovation (2021)
25. Targeting Wnt Signaling Pathway by Polyphenols: Implication for Aging and Age-Related Diseases, Biogerontology (2021)
26. A State-Of-The-Art Review on Solid Lipid Nanoparticles As a Nanovaccines Delivery System, Journal of Drug Delivery Science and Technology (2023)
27. Nanovehicle-Based Small Interfering Rna (Sirna) Delivery for Therapeutic Purposes: A New Molecular Approach in Pharmacogenomics, Current Clinical Pharmacology (2018)
28. Application of Nanomedicine for Crossing the Blood–Brain Barrier: Theranostic Opportunities in Multiple Sclerosis, Journal of Immunotoxicology (2016)
29. Biomaterials and Stem Cells As Drug/Gene-Delivery Vehicles for Parkinson's Treatment: An Update, Regenerative Medicine (2021)
30. Glyco-Nanoparticles: New Drug Delivery Systems in Cancer Therapy, Seminars in Cancer Biology (2021)
31. Superoxide Dismutase: A Key Target for the Neuroprotective Effects of Curcumin, Molecular and Cellular Biochemistry (2024)
32. Recent Advances on Biocompatible and Biodegradable Nanoparticles As Gene Carriers, Expert Opinion on Biological Therapy (2016)
33. Advances in Alzheimer's Diagnosis and Therapy: The Implications of Nanotechnology, Trends in Biotechnology (2017)
34. Biomedical Applications of Intelligent Nanomaterials, Intelligent Nanomaterials: Second Edition (2016)
35. Topical Delivery of Bee Venom Through the Skin by a Water-In-Oil Nanoemulsion, Nanomedicine Journal (2022)
36. Tailoring Synthetic Polymeric Biomaterials Towards Nerve Tissue Engineering: A Review, Artificial Cells# Nanomedicine and Biotechnology (2019)
37. Preparation of Curcumin-Loaded Plga Nanoparticles and Investigation of Its Cytotoxicity Effects on Human Glioblastoma U87mg Cells, Biointerface Research in Applied Chemistry (2019)
38. The Effects of Oxygen–Ozone Therapy on Regulatory T-Cell Responses in Multiple Sclerosis Patients, Cell Biology International (2021)
39. Regulation of Autophagy by Polyphenols: Paving the Road for Treatment of Neurodegeneration, Biotechnology Advances (2018)
40. Electrochemical Micro- and Nanobiosensors for in Vivo Reactive Oxygen/Nitrogen Species Measurement in the Brain, Nanotechnology Reviews (2023)
41. Overcoming the Blood-Brain Barrier in Neurodegenerative Disorders and Brain Tumours, IET Nanobiotechnology (2020)
42. Targeting Mtors by Omega-3 Fatty Acids: A Possible Novel Therapeutic Strategy for Neurodegeneration?, Pharmacological Research (2018)
43. Protective Effects of Flavonoids Against Alzheimer's Disease-Related Neural Dysfunctions, Biomedicine and Pharmacotherapy (2017)
44. Albuminated Plga Nanoparticles Containing Bevacizumab Intended for Ocular Neovascularization Treatment, Journal of Biomedical Materials Research - Part A (2015)
45. Nano Conjugated Plga-Chlorambucil: Synthesis in Vitro Anti Non-Hodgkin's Lymphoma Cellular Assay, Letters in Drug Design and Discovery (2017)
46. Novel Neuroprotective Potential of Crocin in Neurodegenerative Disorders: An Illustrated Mechanistic Review, Neurochemical Research (2020)
47. Peptide Acylation in Aliphatic Polyesters: A Review of Mechanisms and Inhibition Strategies, Pharmaceutical Research (2024)
48. Development of a Facile, Versatile and Scalable Fabrication Approach of Solid, Coated, and Dissolving Microneedle Devices for Transdermal Drug Delivery Applications, Giant (2024)
49. An Insight Into the Toxicological Impacts of Carbon Nanotubes (Cnts) on Human Health: A Review, Environmental Advances (2024)