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Potential Treatment of Parkinson's Disease Using New-Generation Carbon Nanotubes: A Biomolecular in Silico Study Publisher Pubmed



Alimohammadi E1 ; Nikzad A2 ; Khedri M3 ; Rezaian M4 ; Jahromi AM5 ; Rezaei N6, 7, 8 ; Maleki R9
Authors
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Authors Affiliations
  1. 1. Neurosurgery Department, Kermanshah University of Medical Sciences, Kermanshah, Iran
  2. 2. Department of Mechanical Engineering, University of British Columbia, 2054-6250 Applied Science Lane, Vancouver, V6T1Z4, BC, Canada
  3. 3. Department of Chemical Engineering, Amirkabir University of Technology (Tehran Polytechnic), 424 Hafez Avenue, Tehran, 1591634311, Iran
  4. 4. School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, 1983963113, Iran
  5. 5. Department of Petroleum Engineering, Amirkabir University of Technology (Tehran Polytechnic), 424 Hafez Avenue, Tehran, 1591634311, Iran
  6. 6. Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  8. 8. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  9. 9. Computational Biology and Chemistry Group (CBCG), Universal Scientific Education and Research Network (USERN), Tehran, Iran

Source: Nanomedicine Published:2021


Abstract

Background: One of the underlying mechanisms of Parkinson's disease is the aggregation of α-synuclein proteins, including amyloids and Lewy bodies in the brain. Aim: To study the inhibitory effect of doped carbon nanotubes (CNTs) on amyloid aggregation. Materials & methods: Molecular dynamics tools were utilized to simulate the influence of CNTs doped with phosphorus, nitrogen and bromine and nitrogen on the formation of α-synuclein amyloid. Results: The CNTs exhibited strong interactions with α-synuclein, with phosphorus-doped CNTs having the most substantial interactions. Conclusion: Doped-CNTs, especially phosphorus-doped carbon nanotube could effectively prevent α-synuclein amyloid formation, thus, it could be considered as a potential treatment for Parkinson's disease. However, further in vitro and clinical investigations are required. © 2021 Future Medicine Ltd.
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