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Novel Therapeutic Strategies for Alzheimer's Disease: Implications From Cell-Based Therapy and Nanotherapy Publisher Pubmed



Derakhshankhah H1 ; Sajadimajd S2 ; Jafari S1 ; Izadi Z1 ; Sarvari S3 ; Sharifi M4 ; Falahati M4 ; Moakedi F5 ; Muganda WCA6 ; Muller M6 ; Raoufi M6, 7 ; Presley JF8
Authors
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Authors Affiliations
  1. 1. Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
  2. 2. Department of Biology, Faculty of Science, Razi University, Kermanshah, Iran
  3. 3. Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran
  4. 4. Department of Nanotechnology, Faculty of Advance Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  5. 5. Health Science Center, West Virginia University, Morgantown, United States
  6. 6. Physical Chemistry I and Research Center of Micro and Nanochemistry (Cμ), University of Siegen, Siegen, Germany
  7. 7. Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Department of Anatomy and Cell Biology, McGill University, Montreal, Canada

Source: Nanomedicine: Nanotechnology# Biology# and Medicine Published:2020


Abstract

Alzheimer's disease (AD) is a multifactorial neurodegenerative disease which leads to progressive dysfunction of cognition, memory and learning in elderly people. Common therapeutic agents are not only inadequate to suppress the progression of AD pathogenesis but also produce deleterious side effects; hence, development of alternative therapies is required to specifically suppress complications of AD. The current review provides a commentary on conventional as well as novel therapeutic approaches with an emphasis on stem cell and nano-based therapies for improvement and management of AD pathogenesis. According to our overview of the current literature, AD is a multi-factorial disorder with various pathogenic trajectories; hence, a multifunctional strategy to create effective neuroprotective agents is required to treat this disorder. © 2020 Elsevier Inc.
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