Novel Therapeutic Strategies for Alzheimer's Disease: Implications From Cell-Based Therapy and Nanotherapy Publisher Pubmed



Derakhshankhah H¹ ; Sajadimajd S² ; Jafari S¹ ; Izadi Z¹ ; Sarvari S³ ; Sharifi M⁴ ; Falahati M⁴ ; Moakedi F⁵ ; Muganda WCA⁶ ; Muller M⁶ ; Raoufi M^{6, 7} ; Presley JF⁸
Source: Nanomedicine: Nanotechnology# Biology# and Medicine Published:2020

Abstract

Alzheimer's disease (AD) is a multifactorial neurodegenerative disease which leads to progressive dysfunction of cognition, memory and learning in elderly people. Common therapeutic agents are not only inadequate to suppress the progression of AD pathogenesis but also produce deleterious side effects; hence, development of alternative therapies is required to specifically suppress complications of AD. The current review provides a commentary on conventional as well as novel therapeutic approaches with an emphasis on stem cell and nano-based therapies for improvement and management of AD pathogenesis. According to our overview of the current literature, AD is a multi-factorial disorder with various pathogenic trajectories; hence, a multifunctional strategy to create effective neuroprotective agents is required to treat this disorder. © 2020 Elsevier Inc.