Decreased Serum Microrna-21 Level Is Associated With Obesity in Healthy and Type 2 Diabetic Subjects Publisher Pubmed



Ghorbani S¹ ; Mahdavi R² ; Alipoor B³ ; Panahi G² ; Nasli Esfahani E^{4, 5} ; Razi F^{4, 5} ; Taghikhani M¹ ; Meshkani R² Show Affiliations
Source: Archives of Physiology and Biochemistry Published:2018

Abstract

Background: Recently, much attention has been paid to the role of circulating microRNAs (miRNAs) as novel biomarkers for various diseases. The aim of this study was to investigate the level of a subset of miRNAs in serum samples of the diabetic and healthy subjects. Methods: Forty two healthy and 45 T2D subjects participated in this study. Serum miR-21, miR-126, and miR-146a levels were measured using real-time PCR. Results: There was no significant difference in the serum level of miR-21, miR-126, and miR-146a between the diabetic and non-diabetic groups. The level of miR-21 in obese non-diabetic and diabetic subjects was significantly lower than lean subjects. Correlation analyses in non-diabetic and diabetic groups revealed a significant negative correlation between the amount of miR-21 and body mass index, waist circumference, insulin, and HOMA-IR levels. Conclusions: A reduced level of miR-21 might associate with obesity and its related metabolic traits such as hyperinsulinaemia. © 2017, © 2017 Informa UK Limited, trading as Taylor & Francis Group.