Evaluation of Mir-181B and Mir-126-5P Expression Levels in T2dm Patients Compared to Healthy Individuals: Relationship With Nf-Κb Gene Expression; [Evaluacion De Los Niveles De Expresion De Mir-181B Y Mir-126-5P En Pacientes Con Dmt2 Comparados Con Personas Sanas: Relacion Con La Expresion Del Gen Nf-Κb]

Evaluation of Mir-181B and Mir-126-5P Expression Levels in T2dm Patients Compared to Healthy Individuals: Relationship With Nf-Κb Gene Expression; [Evaluacion De Los Niveles De Expresion De Mir-181B Y Mir-126-5P En Pacientes Con Dmt2 Comparados Con Personas Sanas: Relacion Con La Expresion Del Gen Nf-Κb] Publisher Pubmed

Dehghani M¹ ; Aghaei Zarch SM² ; Vahidi Mehrjardi MY¹ ; Nazari M² ; Babakhanzadeh E² ; Ghadimi H³ ; Zeinali F⁴ ; Talebi M²

Show Affiliations

1. Medical Genetics Research Centre, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2. Department of Medical Genetics, School of Medicine, Shahid Sadoughi University of Medical Science, Yazd, Iran
3. Department of Genetics, Tehran University of Medical Sciences, Tehran, Iran
4. Department of Nutrition, Shahid Sadoughi University of Medical Science, Yazd, Iran

Source: Endocrinologia# Diabetes y Nutricion Published:2020

Abstract

Background: Type 2 diabetes mellitus (T2DM) is a progressive metabolic disorder whose prevalence is rising very fast across the world. Diagnosis of this disease in early stages (pre-diabetic stage) plays an important role in reducing mortality associated with this disorder. miRNAs, as key players in the pathogenesis of T2DM, have been investigated in several studies. Furthermore, their expression profile changes in the early stages of diabetes mellitus in body fluids such as serum, peripheral blood, and peripheral blood mononuclear cell (PBMC) have been studied. Due to their high stability and the presence of non-invasive sensitive methods for their measurement, such as real-time PCR, they can be used for early diagnosis of T2DM as a biomarker. In this experimental study, the expression levels of miR-181b, miR-126-5p, and NF-κB were measured in patients with T2DM, pre-diabetic subjects, and healthy controls in a Yazd population. Material and method: Ninety asymptomatic subjects including 30 T2DM, 30 pre-diabetic, and 30 healthy subjects (diagnosis based on WHO criteria) were included in this study. Real-time PCR was used to measure the expression levels of miR-181b and miR-126-5p. Moreover, the NF-κB expression level was also measured to determine its relationship with these two microRNAs. Result: In this study, the expression level of miR-181b and miR-126-p decreased gradually in pre-diabetic as well as T2DM subjects compared to healthy controls. Furthermore, our study showed a significant negative correlation between these two miRNAs and NF-κB for the first time. Conclusion: These results introduce these anti-inflammatory miRNAs as powerful tools for early diagnosis of T2DM. © 2019 SEEN y SED

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Style	Citing Format
MLA	Dehghani M, et al.. "Evaluation of Mir-181B and Mir-126-5P Expression Levels in T2dm Patients Compared to Healthy Individuals: Relationship With Nf-Κb Gene Expression; [Evaluacion De Los Niveles De Expresion De Mir-181B Y Mir-126-5P En Pacientes Con Dmt2 Comparados Con Personas Sanas: Relacion Con La Expresion Del Gen Nf-Κb]." Endocrinologia# Diabetes y Nutricion, vol. 67, no. 7, 2020, pp. 454-460.
APA	Dehghani M, Aghaei Zarch SM, Vahidi Mehrjardi MY, Nazari M, Babakhanzadeh E, Ghadimi H, Zeinali F, Talebi M (2020). Evaluation of Mir-181B and Mir-126-5P Expression Levels in T2dm Patients Compared to Healthy Individuals: Relationship With Nf-Κb Gene Expression; [Evaluacion De Los Niveles De Expresion De Mir-181B Y Mir-126-5P En Pacientes Con Dmt2 Comparados Con Personas Sanas: Relacion Con La Expresion Del Gen Nf-Κb]. Endocrinologia# Diabetes y Nutricion, 67(7), 454-460.
Chicago	Dehghani M, Aghaei Zarch SM, Vahidi Mehrjardi MY, Nazari M, Babakhanzadeh E, Ghadimi H, Zeinali F, Talebi M. "Evaluation of Mir-181B and Mir-126-5P Expression Levels in T2dm Patients Compared to Healthy Individuals: Relationship With Nf-Κb Gene Expression; [Evaluacion De Los Niveles De Expresion De Mir-181B Y Mir-126-5P En Pacientes Con Dmt2 Comparados Con Personas Sanas: Relacion Con La Expresion Del Gen Nf-Κb]." Endocrinologia# Diabetes y Nutricion 67, no. 7 (2020): 454-460.
Harvard	Dehghani M et al. (2020) 'Evaluation of Mir-181B and Mir-126-5P Expression Levels in T2dm Patients Compared to Healthy Individuals: Relationship With Nf-Κb Gene Expression; [Evaluacion De Los Niveles De Expresion De Mir-181B Y Mir-126-5P En Pacientes Con Dmt2 Comparados Con Personas Sanas: Relacion Con La Expresion Del Gen Nf-Κb]', Endocrinologia# Diabetes y Nutricion, 67(7), pp. 454-460.
Vancouver	Dehghani M, Aghaei Zarch SM, Vahidi Mehrjardi MY, Nazari M, Babakhanzadeh E, Ghadimi H, et al.. Evaluation of Mir-181B and Mir-126-5P Expression Levels in T2dm Patients Compared to Healthy Individuals: Relationship With Nf-Κb Gene Expression; [Evaluacion De Los Niveles De Expresion De Mir-181B Y Mir-126-5P En Pacientes Con Dmt2 Comparados Con Personas Sanas: Relacion Con La Expresion Del Gen Nf-Κb]. Endocrinologia# Diabetes y Nutricion. 2020;67(7):454-460.
BibTex	@article{ author = {Dehghani M and Aghaei Zarch SM and Vahidi Mehrjardi MY and Nazari M and Babakhanzadeh E and Ghadimi H and Zeinali F and Talebi M}, title = {Evaluation of Mir-181B and Mir-126-5P Expression Levels in T2dm Patients Compared to Healthy Individuals: Relationship With Nf-Κb Gene Expression; [Evaluacion De Los Niveles De Expresion De Mir-181B Y Mir-126-5P En Pacientes Con Dmt2 Comparados Con Personas Sanas: Relacion Con La Expresion Del Gen Nf-Κb]}, journal = {Endocrinologia# Diabetes y Nutricion}, volume = {67}, number = {7}, pages = {454-460}, year = {2020} }
RIS	TY - JOUR AU - Dehghani M AU - Aghaei Zarch SM AU - Vahidi Mehrjardi MY AU - Nazari M AU - Babakhanzadeh E AU - Ghadimi H AU - Zeinali F AU - Talebi M TI - Evaluation of Mir-181B and Mir-126-5P Expression Levels in T2dm Patients Compared to Healthy Individuals: Relationship With Nf-Κb Gene Expression; [Evaluacion De Los Niveles De Expresion De Mir-181B Y Mir-126-5P En Pacientes Con Dmt2 Comparados Con Personas Sanas: Relacion Con La Expresion Del Gen Nf-Κb] JO - Endocrinologia# Diabetes y Nutricion VL - 67 IS - 7 SP - 454 EP - 460 PY - 2020 ER -

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