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Genetics of Migraine: Where Are We Now? Publisher Pubmed



Grangeon L1 ; Lange KS2, 3 ; Waliszewskaprosol M4 ; Onan D5 ; Marschollek K4 ; Wiels W6 ; Mikulenka P7 ; Farham F8 ; Gollion C9 ; Ducros A10
Authors
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Authors Affiliations
  1. 1. Neurology Department, CHU de Rouen, Rouen, France
  2. 2. Neurology Department, Charite – Universitatsmedizin Berlin, Berlin, Germany
  3. 3. Center for Stroke Research Berlin (CSB), Charite – Universitatsmedizin, Berlin, Germany
  4. 4. Department of Neurology, Wroclaw Medical University, Wroclaw, Poland
  5. 5. Hacettepe University, Faculty of Physical Therapy and Rehabilitation, Ankara, Turkey
  6. 6. Department of Neurology, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium
  7. 7. Department of Neurology, Third Faculty of Medicine, Charles University and University Hospital Kralovske Vinohrady, Prague, Czech Republic
  8. 8. Headache Department, Iranian Centre of Neurological Researchers, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
  9. 9. Neurology Department, CHU de Toulouse, Toulouse, France
  10. 10. Neurology Department, CHU de Montpellier, 80 avenue Augustin Fliche, Montpellier, 34295, France

Source: Journal of Headache and Pain Published:2023


Abstract

Migraine is a complex brain disorder explained by the interaction of genetic and environmental factors. In monogenic migraines, including familial hemiplegic migraine and migraine with aura associated with hereditary small-vessel disorders, the identified genes code for proteins expressed in neurons, glial cells, or vessels, all of which increase susceptibility to cortical spreading depression. The study of monogenic migraines has shown that the neurovascular unit plays a prominent role in migraine. Genome-wide association studies have identified numerous susceptibility variants that each result in only a small increase in overall migraine risk. The more than 180 known variants belong to several complex networks of “pro-migraine” molecular abnormalities, which are mainly neuronal or vascular. Genetics has also highlighted the importance of shared genetic factors between migraine and its major co-morbidities, including depression and high blood pressure. Further studies are still needed to map all of the susceptibility loci for migraine and then to understand how these genomic variants lead to migraine cell phenotypes. © 2023, The Author(s).
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