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Detection of Hpv Genotypes and Their Association With P53 Codon 72 Polymorphism in Prostate Cancer Publisher



Babakhani F1 ; Azad TM1 ; Kondori N2 ; Jalilvand S1 ; Mozhgani SH1 ; Ghavami N1 ; Farzanehpour M1 ; Babaei F3
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Authors Affiliations
  1. 1. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Pediatric Department, Faculty Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
  3. 3. Department of Microbiology, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

Source: Future Virology Published:2017


Abstract

Aim: In this study, we focused on the p53 codon 72 polymorphism and HPV infections as a possible contributing factor in susceptibility to prostate cancer (PCa). Methods: Eighty histopathologically confirmed prostate biopsies comprising of 40 cancer cases and 40 benign prostate hyperplasia cases were used. Results: A significant difference was not observed between HPV presence and PCa progression. Our results showed that the p53 protein with Arg (p53-Arg72) variant contributes to the development of PCa. Conclusion: There is a near-significant association between Arg/Arg polymorphism and PCa. © 2017 Future Medicine Ltd.
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