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Low-Voltage Online Stimulated Microextraction of Glibenclamide From Whole Blood Publisher



Norouzi P1, 2 ; Rezaei Akmal M1 ; Mofidi Z1 ; Larijani B3 ; Ganjali MR1, 2 ; Ebrahimi M1
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Authors Affiliations
  1. 1. Center of Excellence in Electrochemistry, School of Chemistry, College of Science, University of Tehran, Tehran, Iran
  2. 2. Biosensor Research Center, Endocrinology & Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Endocrinology & Metabolism Research Center, Endocrinology & Metabolism, Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Microchemical Journal Published:2019


Abstract

In the present study, Glibenclamide (GLI)was determined in blood samples through the application of a method based on coupling low-voltage electromembrane extraction (LV-EME)and fast Fourier transform square wave voltammetry (FFTSWV). The parameters influencing the LV-EME of GLI (i.e. extraction time, electrical potential and pH of donor phases)were optimized using a central composite design (CCD)and the optimal values of the important parameters for the LV-EME-FFTSWV were obtained to be (frequency = 1420 Hz/amplitude = 20 mV, extraction time = 30 min, applied voltage = 5 V, supported liquid membrane (SLM)= 1-octanol, pH values of the feed and receive sources = 8.0 and 7.0). Under these conditions, GLI was extracted from blood samples with a recovery percentage of 26. The LV-EME-FFTSWV method was found to have linear responses over two wide concentration ranges of 10–1000 and 1000–10,000 ng/mL and determination coefficients of 0.997 and 0.994, respectively. The limits of detection and quantification of 3 ng/mL and 10 ng/mL and also the intra- and inter-day precisions of 3.8% and 5.1% were determined. © 2019
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