Effects of Endurance Training on Hsa-Mir-223, P2ry Nd Platelet Function in Type 2 Diabetic Patients Publisher Pubmed



Taghizadeh M¹ ; Ahmadizad S¹ ; Naderi M² Show Affiliations
Source: Clinical Hemorheology and Microcirculation Published:2018

Abstract

BACKGROUND: Type 2 diabetes mellitus (T2DM) is associated with thrombotic events due to platelets' defects. OBJECTIVE:The aim of this studywas to investigate the effects of endurance training on expressions of platelet hsa-miR-223 and P2RY12 receptor, as well as platelet function in T2DM patients. METHODS: Twenty female T2DM patients (age, 62.25±3.81 yr; weight, 73.53±9.04 kg; height, 154.7±4.3 cm) were randomly divided into two groups (Control (CONT) and endurance training (ET)). Subjects in ET group performed eight weeks of running on treadmill at 60-75% of VO2peak (moderate intensity), 3 sessions per week, while, the subjects in control group were not involved in any kind of exercise training. Two blood samples were taken before and 48 h after the training and were analyzed for platelet aggregation, and hsa-miR-223 and P2RY12 expressions. RESULTS: Although platelet aggregation decreased significantly in ET group (P < 0.05), these changes were not significantly different between two groups. Expression of platelet hsa-miR-223 increased and P2RY12 mRNA reduced following ET nonsignificantly. However, decreases in fasting blood glucose, glycated hemoglobin and body weight, and increases in VO2peak following ET were significantly different when compared to control group (P < 0.05). CONCLUSIONS: Short-term endurance training dose not induce up-regulation of hsa-miR-223 and down-regulation of P2RY12, while it has a positive impact on platelet function, glycemic indices, physical fitness and body composition in female T2DM patients. © 2018 - IOS Press and the authors.