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The Resistance to Plague Infection Among Meriones Persicus From Endemic and Non-Endemic Regions in Iran: The Role of Gut Microbiota



Assmar M1 ; Keypour M2, 3 ; Rohani M3, 4 ; Mostafavi E2, 3 ; Daneshvar Farhud D5, 6
Authors
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Authors Affiliations
  1. 1. Dept. of Parasitology, Pasteur Institute of Iran, Tehran, Iran
  2. 2. Dept. of Epidemiology and Biostatistics, Research Center for Emerging and Reemerging Infectious Diseases, Pasteur Institute of Iran, Tehran, Iran
  3. 3. National Reference Laboratory for Plague, Tularemia and Q Fever, Research Centre for Emerging and Reemerging Infectious Diseases, Pasteur Institute of Iran, Hamadan, Iran
  4. 4. Dept. of Microbiology, Pasteur Institute of Iran, Tehran, Iran
  5. 5. School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Dept. of Basic Sciences/Ethics, Iranian Academy of Medical Sciences, Tehran, Iran

Source: Iranian Journal of Public Health Published:2018

Abstract

Background: The present study was conducted approximately 40 years ago, but its results have not been re-leased. At the time of this study, the importance of the gut microbiota was not fully understood. Methods: Meriones persicus rodents, as one of the major reservoirs of Yersinia pestis bacterium in Iran, were compared in a disease endemic area (Akanlu, Hamadan, western Iran) and a non-endemic zone (Telo, Teh-ran, Iran) from 1977 to1981. Results: This study was able to transmit the resistance to Y. pestis to other rodents creatively by using and transferring gut microbiota. Conclusion: The study indicated for the first time that the gut microbiota could affect the sensitivity to plague in Meriones in Telo. © 2018, Iranian Journal of Public Health. All rights reserved.
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