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Intestinal Colonization by Campylobacter Jejuni, Clostridium Difficile, and Clostridium Perfringens Among Commensal Rattus Norvegicus in the Urban Areas of Tehran, Iran Publisher Pubmed



Azimi T1 ; Nasrollahian S1 ; Sabour S2 ; Mosadegh M3 ; Hadi N1 ; Azimi L4 ; Fallah F4 ; Pourmand MR3
Authors
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Authors Affiliations
  1. 1. Department of Bacteriology and Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  2. 2. Department of Microbiology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  3. 3. Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Pediatric Infections Research Center, Research Institute for Children's Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: BioMed Research International Published:2024


Abstract

Background. Rattus norvegicus (R. norvegicus) population plays a significant role in the spread of numerous diseases in urban environments. The present study is aimed at investigating the presence of Campylobacter jejuni (C. jejuni), C. coli, Clostridium difficile (C. difficile), C. difficile toxigenic, and C. perfringens in R. norvegicus captured from urban areas of Tehran, Iran. Methods. From October 2021 to October 2022, 100 urban rats were trapped in 5 different districts of Tehran, Iran. The genomic DNA was extracted from fecal samples, and the presence of C. jejuni, C. coli, C. perfringens, and C. difficile species was evaluated using PCR assay. Moreover, PCR was used to assess the toxicity of C. difficile isolates. Results. Overall, 30% (n=30/100) of fecal samples were positive for zoonotic pathogens. Based on the PCR on hippuricase (hipO), glycine (gly), CIDIF, and phospholipase C (plc) genes, C. perfringens and C. difficile were isolated from 18.2% (n=14/77) and 5.2% (n=4/77) of male rats. The highest frequency of C. perfringens and C. jejuni was 25% (n=5/20) related to the south of Tehran. Toxigenic C. difficile was not detected in all regions. Conclusion. According to the findings, rats are the main reservoirs for diseases. Therefore, rodent control coupled with the implementation of surveillance systems should be prioritized for urban health. © 2024 Taher Azimi et al.
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