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Clinical Presentation, Disease Course, and Outcome of Covid-19 in Hospitalized Patients With and Without Pre-Existing Cardiac Disease: A Cohort Study Across 18 Countries Publisher Pubmed



Asselbergs FW1, 2, 3, 9, 11 ; Linschoten M3 ; Uijl A4 ; Schut A5 ; Jakob CEM6, 7 ; Romao LR8, 9 ; Bell RM10 ; Mcfarlane E11 ; Stecher M6, 7 ; Zondag AGM4 ; Van Iperen EPA12 ; Hermansvan Ast JF12 ; Lea NC9 ; Schaap J5, 13 Show All Authors
Authors
  1. Asselbergs FW1, 2, 3, 9, 11
  2. Linschoten M3
  3. Uijl A4
  4. Schut A5
  5. Jakob CEM6, 7
  6. Romao LR8, 9
  7. Bell RM10
  8. Mcfarlane E11
  9. Stecher M6, 7
  10. Zondag AGM4
  11. Van Iperen EPA12
  12. Hermansvan Ast JF12
  13. Lea NC9
  14. Schaap J5, 13
  15. Jewbali LS14, 15
  16. Smits PC16
  17. Patel RS9, 11
  18. Aujayeb A17
  19. Van Der Harst P3
  20. Siebelink HJ18
  21. Van Smeden M4
  22. Williams S19
  23. Pilgram L20
  24. Van Gilst WH21
  25. Tieleman RG21, 22
  26. Williams B8
  27. Alali AK23
  28. Almuhanna FA24
  29. Alrubaish AM24
  30. Alwindy NYY25
  31. Alkhalil M26
  32. Almubarak YA27
  33. Alnafie AN28
  34. Alshahrani M29
  35. Alshehri AM30
  36. Anning C31
  37. Anthonio RL32
  38. Badings EA33
  39. Ball C31
  40. Van Beek EA34
  41. Ten Berg JM35
  42. Von Bergweltbaildon M36, 37, 38
  43. Bianco M39
  44. Blagova OV40
  45. Bleijendaal H41, 42
  46. Bor WL35
  47. Borgmann S43
  48. Van Boxem AJM44
  49. Van Den Brink FS45
  50. Bucciarelliducci C46
  51. Van Bussel BCT47, 48
  52. Byromgoulthorp R49
  53. Captur G11, 50
  54. Caputo M51, 52
  55. Charlotte N53
  56. Vom Dahl J54
  57. Dark P55
  58. De Sutter J56, 57
  59. Degenhardt C58
  60. Delsing CE59
  61. Dolff S60
  62. Dorman HGR61
  63. Drost JT62
  64. Eberwein L63
  65. Emans ME64
  66. Er AG65
  67. Ferreira JB66
  68. Forner MJ67, 68
  69. Friedrichs A69
  70. Gabriel L70
  71. Groenemeijer BE71
  72. Groenendijk AL72
  73. Gruner B73
  74. Guggemos W74
  75. Haerkensarends HE75
  76. Hanses F76
  77. Hedayat B77
  78. Heigener D78
  79. Van Der Heijden DJ79
  80. Hellou E80
  81. Hellwig K81
  82. Henkens MTHM82, 87
  83. Hermanides RS83
  84. Hermans WRM84
  85. Van Hessen MWJ85
  86. Heymans SRB82, 86, 87
  87. Hilt AD18
  88. Van Der Horst ICC47, 88
  89. Hower M89
  90. Van Ierssel SH90
  91. Isberner N91
  92. Jensen B92
  93. Kearney MT49
  94. Van Kesteren HAM93
  95. Kielstein JT94
  96. Kietselaer BLJH95
  97. Kochanek M96
  98. Kolk MZH41
  99. Koning AMH97
  100. Kopylov PY98
  101. Kuijper AFM99
  102. Kwakkelvan Erp JM100
  103. Lanznaster J101
  104. Van Der Linden MMJM102
  105. Van Der Lingen ACJ103
  106. Linssen GCM104
  107. Lomas D55
  108. Maarse M35
  109. Macias Ruiz R105
  110. Magdelijns FJH106
  111. Magro M84
  112. Markart P107, 108
  113. Martens FMAC33
  114. Mazzilli SG109
  115. Mccann GP110
  116. Van Der Meer P111
  117. Meijs MFL112
  118. Merle U113
  119. Messiaen P114, 115
  120. Milovanovic M116
  121. Monraats PS84
  122. Montagna L117
  123. Moriarty A118
  124. Moss AJ110
  125. Mosterd A119
  126. Nadalin S120
  127. Nattermann J121
  128. Neufang M122
  129. Nierop PR123
  130. Offerhaus JA41
  131. Van Ofwegenhanekamp CEE124
  132. Parker E110
  133. Persoon AM125
  134. Piepel C126
  135. Pinto YM41
  136. Poorhosseini H127
  137. Prasad S128, 129
  138. Raafs AG82
  139. Raichle C130
  140. Rauschning D131
  141. Redon J67, 68
  142. Reidinga AC132
  143. Ribeiro MIA133
  144. Riedel C134
  145. Rieg S135
  146. Ripley DP136
  147. Rommele C137
  148. Rothfuss K138
  149. Ruddel J139
  150. Ruthrich MM140
  151. Salah R141
  152. Saneei E142
  153. Saxena M143
  154. Schellings DAAM144
  155. Scholte NTB14
  156. Schubert J145
  157. Seelig J146
  158. Shafiee A147
  159. Shore AC31
  160. Spinner C148
  161. Stieglitz S149
  162. Strauss R150
  163. Sturkenboom NH151
  164. Tessitore E152
  165. Thomson RJ153, 154
  166. Tio RA151, 156
  167. Tjong FVY41, 103, 157
  168. Tometten L158
  169. Trauth J159
  170. Den Uil CA14, 15, 160
  171. Van Craenenbroeck EM161
  172. Van Veen HPAA162
  173. Vehreschild MJGT163
  174. Veldhuis LI164
  175. Veneman T165
  176. Verschure DO166
  177. Voigt I167
  178. De Vries JK168
  179. Van De Wal RMA169
  180. Walter L170
  181. Van De Watering DJ171
  182. Westendorp ICD172
  183. Westendorp PHM173
  184. Westhoff T174
  185. Weytjens C175
  186. Wierda E157
  187. Wille K176
  188. De With K177
  189. Worm M178
  190. Woudstra P45
  191. Wu KW179
  192. Zaal R180
  193. Zaman AG181
  194. Van Der Zee PM34
  195. Zijlstra LE18
  196. Alling TE3
  197. Ahmed R182
  198. Van Aken K111
  199. Bayraktarverver ECE99
  200. Bermudez Jimenes FJ105
  201. Biole CA117
  202. Den Boerpenning P64
  203. Bontje M124
  204. Bos M85
  205. Bosch L124
  206. Broekman M85
  207. Broeyer FJF183
  208. De Bruijn EAW184
  209. Bruinsma S168
  210. Cardoso NM133
  211. Cosyns B175
  212. Van Dalen DH75
  213. Dekimpe E155
  214. Domange J70
  215. Van Doorn JL119
  216. Van Doorn P119
  217. Dormal F70
  218. Drost IMJ144
  219. Dunnink A83
  220. Van Eck JWM75
  221. Elshinawy K185
  222. Gevers RMM75
  223. Gognieva DG98
  224. Van Der Graaf M14
  225. Grangeon S186
  226. Guclu A83
  227. Habib A185
  228. Haenen NA169
  229. Hamilton K111
  230. Handgraaf S152
  231. Heidbuchel H161
  232. Hendriksvan Woerden M22
  233. Hesselslinnemeijer BM95
  234. Hosseini K77
  235. Huisman J93
  236. Jacobs TC61
  237. Jansen SE71
  238. Janssen A155
  239. Jourdan K70
  240. Ten Kate GL90
  241. Van Kempen MJ179
  242. Kievit CM179
  243. Kleikers P95
  244. Knufman N79
  245. Van Der Kooi SE32
  246. Koole BAS93
  247. Koole MAC172
  248. Kui KK168
  249. Kuiperselferink L104
  250. Lemoine I175
  251. Lensink E166
  252. Van Marrewijk V79
  253. Van Meerbeeck JP100
  254. Meijer EJ62
  255. Melein AJ172
  256. Mesitskaya DF187
  257. Van Nes CPM157
  258. Paris FMA32
  259. Perrelli MG117
  260. Pieterserots A104
  261. Pisters R146
  262. Polkerman BC71
  263. Van Poppel A100
  264. Reinders S144
  265. Reitsma MJ97
  266. Ruiter AH14
  267. Selder JL41, 103
  268. Van Der Sluis A33
  269. Sousa AIC133
  270. Tajdini M188
  271. Tercedor Sanchez L105
  272. Van De Heyning CM161
  273. Vial H186
  274. Vlieghe E90
  275. Vonkeman HE189
  276. Vreugdenhil P22
  277. De Vries TAC41, 146
  278. Willems AM56
  279. Wils AM61
  280. Zoetnugteren SK64

Source: European Heart Journal Published:2022


Abstract

Aims Patients with cardiac disease are considered high risk for poor outcomes following hospitalization with COVID-19. The primary aim of this study was to evaluate heterogeneity in associations between various heart disease subtypes and in-hospital mortality. Methods and results We used data from the CAPACITY-COVID registry and LEOSS study. Multivariable Poisson regression models were fitted to assess the association between different types of pre-existing heart disease and in-hospital mortality. A total of 16 511 patients with COVID-19 were included (21.1% aged 66-75 years; 40.2% female) and 31.5% had a history of heart disease. Patients with heart disease were older, predominantly male, and often had other comorbid conditions when compared with those without. Mortality was higher in patients with cardiac disease (29.7%; n = 1545 vs. 15.9%; n = 1797). However, following multivariable adjustment, this difference was not significant [adjusted risk ratio (aRR) 1.08, 95% confidence interval (CI) 1.02-1.15; P = 0.12 (corrected for multiple testing)]. Associations with in-hospital mortality by heart disease subtypes differed considerably, with the strongest association for heart failure (aRR 1.19, 95% CI 1.10-1.30; P < 0.018) particularly for severe (New York Heart Association class III/IV) heart failure (aRR 1.41, 95% CI 1.20-1.64; P < 0.018). None of the other heart disease subtypes, including ischaemic heart disease, remained significant after multivariable adjustment. Serious cardiac complications were diagnosed in <1% of patients. Conclusion Considerable heterogeneity exists in the strength of association between heart disease subtypes and in-hospital mortality. Of all patients with heart disease, those with heart failure are at greatest risk of death when hospitalized with COVID-19. Serious cardiac complications are rare during hospitalization. © The Author(s) 2021
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