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Clinical Presentation, Disease Course, and Outcome of Covid-19 in Hospitalized Patients With and Without Pre-Existing Cardiac Disease: A Cohort Study Across 18 Countries Publisher Pubmed



Asselbergs FW1, 2, 3, 9, 11 ; Linschoten M3 ; Uijl A4 ; Schut A5 ; Jakob CEM6, 7 ; Romao LR8, 9 ; Bell RM10 ; Mcfarlane E11 ; Stecher M6, 7 ; Zondag AGM4 ; Van Iperen EPA12 ; Hermansvan Ast JF12 ; Lea NC9 ; Schaap J5, 13 Show All Authors
Authors
  1. Asselbergs FW1, 2, 3, 9, 11
  2. Linschoten M3
  3. Uijl A4
  4. Schut A5
  5. Jakob CEM6, 7
  6. Romao LR8, 9
  7. Bell RM10
  8. Mcfarlane E11
  9. Stecher M6, 7
  10. Zondag AGM4
  11. Van Iperen EPA12
  12. Hermansvan Ast JF12
  13. Lea NC9
  14. Schaap J5, 13
  15. Jewbali LS14, 15
  16. Smits PC16
  17. Patel RS9, 11
  18. Aujayeb A17
  19. Van Der Harst P3
  20. Siebelink HJ18
  21. Van Smeden M4
  22. Williams S19
  23. Pilgram L20
  24. Van Gilst WH21
  25. Tieleman RG21, 22
  26. Williams B8
  27. Alali AK23
  28. Almuhanna FA24
  29. Alrubaish AM24
  30. Alwindy NYY25
  31. Alkhalil M26
  32. Almubarak YA27
  33. Alnafie AN28
  34. Alshahrani M29
  35. Alshehri AM30
  36. Anning C31
  37. Anthonio RL32
  38. Badings EA33
  39. Ball C31
  40. Van Beek EA34
  41. Ten Berg JM35
  42. Von Bergweltbaildon M36, 37, 38
  43. Bianco M39
  44. Blagova OV40
  45. Bleijendaal H41, 42
  46. Bor WL35
  47. Borgmann S43
  48. Van Boxem AJM44
  49. Van Den Brink FS45
  50. Bucciarelliducci C46
  51. Van Bussel BCT47, 48
  52. Byromgoulthorp R49
  53. Captur G11, 50
  54. Caputo M51, 52
  55. Charlotte N53
  56. Vom Dahl J54
  57. Dark P55
  58. De Sutter J56, 57
  59. Degenhardt C58
  60. Delsing CE59
  61. Dolff S60
  62. Dorman HGR61
  63. Drost JT62
  64. Eberwein L63
  65. Emans ME64
  66. Er AG65
  67. Ferreira JB66
  68. Forner MJ67, 68
  69. Friedrichs A69
  70. Gabriel L70
  71. Groenemeijer BE71
  72. Groenendijk AL72
  73. Gruner B73
  74. Guggemos W74
  75. Haerkensarends HE75
  76. Hanses F76
  77. Hedayat B77
  78. Heigener D78
  79. Van Der Heijden DJ79
  80. Hellou E80
  81. Hellwig K81
  82. Henkens MTHM82, 87
  83. Hermanides RS83
  84. Hermans WRM84
  85. Van Hessen MWJ85
  86. Heymans SRB82, 86, 87
  87. Hilt AD18
  88. Van Der Horst ICC47, 88
  89. Hower M89
  90. Van Ierssel SH90
  91. Isberner N91
  92. Jensen B92
  93. Kearney MT49
  94. Van Kesteren HAM93
  95. Kielstein JT94
  96. Kietselaer BLJH95
  97. Kochanek M96
  98. Kolk MZH41
  99. Koning AMH97
  100. Kopylov PY98
  101. Kuijper AFM99
  102. Kwakkelvan Erp JM100
  103. Lanznaster J101
  104. Van Der Linden MMJM102
  105. Van Der Lingen ACJ103
  106. Linssen GCM104
  107. Lomas D55
  108. Maarse M35
  109. Macias Ruiz R105
  110. Magdelijns FJH106
  111. Magro M84
  112. Markart P107, 108
  113. Martens FMAC33
  114. Mazzilli SG109
  115. Mccann GP110
  116. Van Der Meer P111
  117. Meijs MFL112
  118. Merle U113
  119. Messiaen P114, 115
  120. Milovanovic M116
  121. Monraats PS84
  122. Montagna L117
  123. Moriarty A118
  124. Moss AJ110
  125. Mosterd A119
  126. Nadalin S120
  127. Nattermann J121
  128. Neufang M122
  129. Nierop PR123
  130. Offerhaus JA41
  131. Van Ofwegenhanekamp CEE124
  132. Parker E110
  133. Persoon AM125
  134. Piepel C126
  135. Pinto YM41
  136. Poorhosseini H127
  137. Prasad S128, 129
  138. Raafs AG82
  139. Raichle C130
  140. Rauschning D131
  141. Redon J67, 68
  142. Reidinga AC132
  143. Ribeiro MIA133
  144. Riedel C134
  145. Rieg S135
  146. Ripley DP136
  147. Rommele C137
  148. Rothfuss K138
  149. Ruddel J139
  150. Ruthrich MM140
  151. Salah R141
  152. Saneei E142
  153. Saxena M143
  154. Schellings DAAM144
  155. Scholte NTB14
  156. Schubert J145
  157. Seelig J146
  158. Shafiee A147
  159. Shore AC31
  160. Spinner C148
  161. Stieglitz S149
  162. Strauss R150
  163. Sturkenboom NH151
  164. Tessitore E152
  165. Thomson RJ153, 154
  166. Tio RA151, 156
  167. Tjong FVY41, 103, 157
  168. Tometten L158
  169. Trauth J159
  170. Den Uil CA14, 15, 160
  171. Van Craenenbroeck EM161
  172. Van Veen HPAA162
  173. Vehreschild MJGT163
  174. Veldhuis LI164
  175. Veneman T165
  176. Verschure DO166
  177. Voigt I167
  178. De Vries JK168
  179. Van De Wal RMA169
  180. Walter L170
  181. Van De Watering DJ171
  182. Westendorp ICD172
  183. Westendorp PHM173
  184. Westhoff T174
  185. Weytjens C175
  186. Wierda E157
  187. Wille K176
  188. De With K177
  189. Worm M178
  190. Woudstra P45
  191. Wu KW179
  192. Zaal R180
  193. Zaman AG181
  194. Van Der Zee PM34
  195. Zijlstra LE18
  196. Alling TE3
  197. Ahmed R182
  198. Van Aken K111
  199. Bayraktarverver ECE99
  200. Bermudez Jimenes FJ105
  201. Biole CA117
  202. Den Boerpenning P64
  203. Bontje M124
  204. Bos M85
  205. Bosch L124
  206. Broekman M85
  207. Broeyer FJF183
  208. De Bruijn EAW184
  209. Bruinsma S168
  210. Cardoso NM133
  211. Cosyns B175
  212. Van Dalen DH75
  213. Dekimpe E155
  214. Domange J70
  215. Van Doorn JL119
  216. Van Doorn P119
  217. Dormal F70
  218. Drost IMJ144
  219. Dunnink A83
  220. Van Eck JWM75
  221. Elshinawy K185
  222. Gevers RMM75
  223. Gognieva DG98
  224. Van Der Graaf M14
  225. Grangeon S186
  226. Guclu A83
  227. Habib A185
  228. Haenen NA169
  229. Hamilton K111
  230. Handgraaf S152
  231. Heidbuchel H161
  232. Hendriksvan Woerden M22
  233. Hesselslinnemeijer BM95
  234. Hosseini K77
  235. Huisman J93
  236. Jacobs TC61
  237. Jansen SE71
  238. Janssen A155
  239. Jourdan K70
  240. Ten Kate GL90
  241. Van Kempen MJ179
  242. Kievit CM179
  243. Kleikers P95
  244. Knufman N79
  245. Van Der Kooi SE32
  246. Koole BAS93
  247. Koole MAC172
  248. Kui KK168
  249. Kuiperselferink L104
  250. Lemoine I175
  251. Lensink E166
  252. Van Marrewijk V79
  253. Van Meerbeeck JP100
  254. Meijer EJ62
  255. Melein AJ172
  256. Mesitskaya DF187
  257. Van Nes CPM157
  258. Paris FMA32
  259. Perrelli MG117
  260. Pieterserots A104
  261. Pisters R146
  262. Polkerman BC71
  263. Van Poppel A100
  264. Reinders S144
  265. Reitsma MJ97
  266. Ruiter AH14
  267. Selder JL41, 103
  268. Van Der Sluis A33
  269. Sousa AIC133
  270. Tajdini M188
  271. Tercedor Sanchez L105
  272. Van De Heyning CM161
  273. Vial H186
  274. Vlieghe E90
  275. Vonkeman HE189
  276. Vreugdenhil P22
  277. De Vries TAC41, 146
  278. Willems AM56
  279. Wils AM61
  280. Zoetnugteren SK64
Show Affiliations
Authors Affiliations
  1. 1. Department of Cardiology, Division of Heart & Lungs, University Medical Center Utrecht, Room E03.511, PO Box 85500, Utrecht, 3508 GA, Netherlands
  2. 2. The Institute of Health Informatics, Institute of Cardiovascular Science, The University College London, London, United Kingdom
  3. 3. Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands
  4. 4. Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands
  5. 5. The Dutch Network for Cardiovascular Research (WCN), Utrecht, Netherlands
  6. 6. Department I of Internal Medicine, University Hospital of Cologne, University of Cologne, Cologne, Germany
  7. 7. German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany
  8. 8. National Institute for Health Research Biomedical Research Center, University College London Hospitals, London, United Kingdom
  9. 9. Health Data Research United Kingdom, Institute of Health Informatics, University College London, London, United Kingdom
  10. 10. The Hatter Cardiovascular Institute, University College London, London, United Kingdom
  11. 11. Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London, United Kingdom
  12. 12. Durrer Center, Netherlands Heart Institute, Utrecht, Netherlands
  13. 13. Department of Cardiology, Amphia Hospital, Netherlands
  14. 14. Department of Cardiology, Erasmus MC University Medical Center, Rotterdam, Netherlands
  15. 15. Department of Intensive Care, Erasmus MC University Medical Center, Rotterdam, Netherlands
  16. 16. Department of Cardiology, Maasstad Hospital, Rotterdam, Netherlands
  17. 17. Department of Respiratory and Acute Medicine, Northumbria Healthcare NHS Foundation Trust, Newcastle, United Kingdom
  18. 18. Department of Cardiology, Leiden University Medical Center, Leiden, Netherlands
  19. 19. Barts Life Sciences, Barts Health NHS Trust, London, United Kingdom
  20. 20. Department of Internal Medicine, Hematology and Oncology, Goethe University Frankfurt, Frankfurt, Germany
  21. 21. Department of Cardiology, University Medical Center Groningen, Groningen, Netherlands
  22. 22. Department of Cardiology, Martini Hospital, Groningen, Netherlands
  23. 23. Department of Clinical Biochemistry, King Fahd Hospital of the University, Imam Abdulrahman Bin Faisal University, Alkhobar, Saudi Arabia
  24. 24. Department of Internal Medicine, King Fahd Hospital of the University, Imam Abdulrahman Bin Faisal University, Alkhobar, Saudi Arabia
  25. 25. Department of Cardiology, Gelre Hospital Zutphen, Zutphen, Netherlands
  26. 26. Department of Cardiothoracic Services, Freeman Hospital, Newcastle University, Newcastle upon Tyne NHS Foundation Trust, United Kingdom
  27. 27. Department of Critical Care, King Fahd Hospital of the University, Imam Abdulrahman Bin Faisal University, Alkhobar, Saudi Arabia
  28. 28. Department of Pathology, King Fahd Hospital of the University, Imam Abdulrahman Bin Faisal University, Alkhobar, Saudi Arabia
  29. 29. Department of Emergency Medicine, King Fahd Hospital of the University, Imam Abdulrahman Bin Faisal University, Alkhobar, Saudi Arabia
  30. 30. Department of Internal Medicine, Cardiology Section, King Fahd Hospital of the University, Imam Abdulrahman Bin Faisal University, Alkhobar, Saudi Arabia
  31. 31. National Institute for Health Research (NIHR) Exeter Clinical Research Facility, Royal Devon and Exeter Hospital, University of Exeter, College of Medicine & Health, Exeter, United Kingdom
  32. 32. Department of Cardiology, Treant Zorggroep, Emmen, Netherlands
  33. 33. Department of Cardiology, Deventer Hospital, Deventer, Netherlands
  34. 34. Department of Cardiology, St. Jansdal Hospital, Harderwijk, Netherlands
  35. 35. Department of Cardiology, St. Antonius Hospital, Nieuwegein, Netherlands
  36. 36. Department of Medicine III, University Hospital Ludwig, Maximilians University, Munich, Germany
  37. 37. German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany
  38. 38. Bavarian Center for Cancer Research (BZKF), Munich, Germany
  39. 39. Intensive Coronary Care Unit, Department of Cardiology, A.O.U. San Luigi Gonzaga, Orbassano, Turin, Italy
  40. 40. Department of Faculty Therapy, No. 1 of N.V. Sklifosovsky Institute for Clinical Medicine, I.M. Sechenov First Moscow State Medical University, Sechenov University, Moscow, Russian Federation
  41. 41. Amsterdam University Medical Center, University of Amsterdam, Heart Center, Department of Clinical and Experimental Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam, Netherlands
  42. 42. Amsterdam University Medical Center, University of Amsterdam, Department of Clinical Epidemiology, Biostatistics & Bioinformatics, Amsterdam, Netherlands
  43. 43. Department of Infectious Diseases and Infection Control, Ingolstadt Hospital, Ingolstadt, Germany
  44. 44. Department of Pulmonology, Bravis Hospital, Roosendaal, Netherlands
  45. 45. Department of Cardiology, Medical Center Leeuwarden (MCL), Leeuwarden, Netherlands
  46. 46. Bristol Heart Institute, Bristol National Institute of Health Research (NIHR), Biomedical Research Center, University Hospitals Bristol NHS Trust, University of Bristol, Bristol, United Kingdom
  47. 47. Department of Intensive Care, Maastricht University Medical Centerþ, Maastricht University, Maastricht, Netherlands
  48. 48. Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, Netherlands
  49. 49. Leeds Institute for Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom
  50. 50. Department of Cardiology, Royal Free London NHS Foundation Trust, London, United Kingdom
  51. 51. Bristol Heart Institute, University Hospitals Bristol, Weston NHS Foundation Trust, Bristol, United Kingdom
  52. 52. Bristol Medical School, University of Bristol, Bristol, United Kingdom
  53. 53. Department of Cardiology, SSR Val Rosay, Saint Didier au Mont d'Or, France
  54. 54. Division of Cardiology, Hospital Maria Hilf Monchengladbach, Monchengladbach, Germany
  55. 55. Department of Critical Care, Salford Royal NHS Foundation Trust, Salford, United Kingdom
  56. 56. Department of Cardiology, AZ Maria Middelares, Ghent, Belgium
  57. 57. Department of Internal Medicine, Ghent University, Ghent, Belgium
  58. 58. Municipal Hospital Karlsruhe, Karlsruhe, Germany
  59. 59. Department of Internal Medicine and Infectious Diseases, Medisch Spectrum Twente, Enschede, Netherlands
  60. 60. Department of Infectious Diseases, West German Center of Infectious Diseases, University Hospital Essen, Essen, Germany
  61. 61. Department of Cardiology, Bravis Hospital, Roosendaal, Netherlands
  62. 62. Department of Cardiology, Saxenburgh Medical Center, Hardenberg, Netherlands
  63. 63. 4th Department of Internal Medicine, Hospital Leverkusen, Leverkusen, Germany
  64. 64. Department of Cardiology, Ikazia Hospital, Rotterdam, Netherlands
  65. 65. Department of Infectious Diseases and Clinical Microbiology, Hacettepe University, School of Medicine, Ankara, Turkey
  66. 66. Department of Cardiology, Hospital Professor Doutor Fernando Fonseca, Amadora, Portugal
  67. 67. Department of Internal Medicine, Clinic University Hospital, INCLIVA Health Research Institute, Valencia, Spain
  68. 68. Department of Medicine, School of Medicine, University of Valencia, Valencia, Spain
  69. 69. Department of Internal Medicine I, University Medical Center Schleswig-Holstein, Kiel, Germany
  70. 70. Department of Cardiology, CHU UCL Namur site Godinne, Universite Catholique de Louvain, Yvoir, Belgium
  71. 71. Department of Cardiology, Gelre Hospital Apeldoorn, Apeldoorn, Netherlands
  72. 72. Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Center, Rotterdam, Netherlands
  73. 73. Clinic of Internal Medicine III, Division of Infectious Diseases, University Hospital Ulm, Ulm, Germany
  74. 74. Munich Clinic Schwabing, University Hospital Ludwig, Maximilians University, Munich, Germany
  75. 75. Department of Cardiology, Jeroen Bosch Hospital, Hertogenbosch, Netherlands
  76. 76. Emergency Department, University Hospital Regensburg, Regensburg, Germany
  77. 77. Department of Cardiology, Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  78. 78. Department of Pulmonology, Agaplesion Diaconia Hospital Rotenburg, Rotenburg, Germany
  79. 79. Department of Cardiology, Haaglanden Medical Center, the Hague, Netherlands
  80. 80. Department of Cardiology, E.M.M.S Hospital, Nazareth, Israel
  81. 81. Department of Neurology, Katholisches Klinikum Bochum, Ruhr University Bochum, Bochum, Germany
  82. 82. Department of Cardiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centerþ, Maastricht, Netherlands
  83. 83. Department of Cardiology, Isala Hospital, Zwolle, Netherlands
  84. 84. Department of Cardiology, Elizabeth-TweeSteden Hospital, Tilburg, Netherlands
  85. 85. Department of Cardiology, Groene Hart Hospital, Gouda, Netherlands
  86. 86. Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, KU Leuven, Belgium
  87. 87. The Netherlands Heart Institute, Utrecht, Netherlands
  88. 88. Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, Maastricht, Netherlands
  89. 89. Clinic for Pulmonology, Infectiology, Internal Medicine and Intensive Care, Hospital Dortmund, Dortmund, Germany
  90. 90. Department of General Internal Medicine, Infectious Diseases and Tropical Medicine, Antwerp University Hospital, Antwerp, Belgium
  91. 91. Department of Internal Medicine II, Division of Infectious Diseases, University Hospital Wurzburg, Wurzburg, Germany
  92. 92. Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Dusseldorf, Heinrich-Heine-University, Dusseldorf, Germany
  93. 93. Department of Cardiology, Admiraal de Ruyter Hospital, Goes, Netherlands
  94. 94. Medical Clinic V, Academic Teaching Hospital Braunschweig, Brunswick, Germany
  95. 95. Department of Cardiology, Zuyderland Medical Center, Heerlen, Netherlands
  96. 96. University of Cologne, First Department of Internal Medicine, Center of Integrated Oncology Aachen Bonn Cologne Dusseldorf, University Hospital Cologne, Cologne, Germany
  97. 97. Department of Gynaecology, Amstelland Hospital, Amstelveen, Netherlands
  98. 98. World-Class Research Center Digital Biodesign and Personalized Healthcare, I.M. Sechenov First Moscow State Medical University, Sechenov University, Moscow, Russian Federation
  99. 99. Department of Cardiology, Spaarne Gasthuis, Haarlem, Netherlands
  100. 100. Department of Pulmonology, Antwerp University Hospital, University of Antwerp, Edegem, Belgium
  101. 101. Department of Internal Medicine II, Passau Hospital, Passau, Germany
  102. 102. Department of Cardiology, Franciscus Vlietland, Schiedam, Netherlands
  103. 103. Department of Cardiology, Vrije Universiteit Amsterdam, Amsterdam Cardiovascular Sciences, Amsterdam, Netherlands
  104. 104. Department of Cardiology, Ziekenhuis Groep Twente (ZGT), Almelo, Netherlands
  105. 105. Arrhythmias Unit, Department of Cardiology, Hospital Universitario Virgen de las Nieves, Granada, Spain
  106. 106. Department of Internal Medicine, Division of General Internal Medicine, Section Geriatric Medicine, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centerþ, Maastricht, Netherlands
  107. 107. Department of Pulmonary Medicine, Medical Clinic V, Fulda Hospital, University Medicine Marburg, Campus Fulda, Fulda, Germany
  108. 108. Department of Internal Medicine, Faculty of Medicine, Universities of Giessen, Marburg Lung Center, Giessen, Germany
  109. 109. Electrophysiology Unit, Department of Cardiology, A.O.U. San Luigi Gonzaga, Orbassano, Turin, Italy
  110. 110. Department of Cardiovascular Sciences, University of Leicester and Cardiovascular Theme, National Institute for Health Research (NIHR), Leicester Biomedical Research Center, Glenfield Hospital, Leicester, United Kingdom
  111. 111. Department of Cardiology, LangeLand Hospital, Zoetermeer, Netherlands
  112. 112. Department of Cardiology, Thorax Center Twente, Medisch Spectrum Twente, Enschede, Netherlands
  113. 113. Department of Gastroenterology and Infectiology, Heidelberg University Hospital, Heidelberg, Germany
  114. 114. Department of Infectious Diseases & Immunity, Jessa Hospital, Hasselt, Belgium
  115. 115. Faculty of Medicine and Life Sciences, Hasselt University, Hasselt, Belgium
  116. 116. Medical Clinic I, Malteser Hospital St. Franziskus-Hospital Flensburg, Flensburg, Germany
  117. 117. Department of Cardiology, A.O.U. San Luigi Gonzaga, Orbassano, Turin, Italy
  118. 118. Cardiovascular Research Unit, Craigavon Area Hospital, Souther Health and Social Care Trust, Portadown, United Kingdom
  119. 119. Department of Cardiology, Meander Medical Center, Amersfoort, Netherlands
  120. 120. Department of General, Visceral and Transplant Surgery, University Hospital Tubingen, Tubingen, Germany
  121. 121. Department of Internal Medicine I, Department of Gastroenterology, Hepatology, Nephrology, Infectiology, Endocrinology and Diabetology, University Hospital Bonn, Bonn, Germany
  122. 122. Evangelical City Hospital Saarbrucken, Saarbrucken, Germany
  123. 123. Department of Cardiology, Franciscus Gasthuis, Rotterdam, Netherlands
  124. 124. Department of Cardiology, Diakonessenhuis, Utrecht, Netherlands
  125. 125. Department of Pulmonology, Diakonessenhuis, Utrecht, Netherlands
  126. 126. Klinikum Bremen-Mitte, Department of Internal Medicine I, Bremen, Germany
  127. 127. Department of Interventional Cardiology, Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  128. 128. National Heart and Lung Institute, Imperial College, London, United Kingdom
  129. 129. Royal Brompton Hospital, London, United Kingdom
  130. 130. Tropical Clinic Paul-Lechler Hospital Tubingen, Tubingen, Germany
  131. 131. Bundeswehr Central Hospital, Koblenz, Germany
  132. 132. Department of Intensive Care, Martini Hospital, Groningen, Netherlands
  133. 133. Intensive Care Unit, Hospital do Espirito Santo, Evora, Portugal
  134. 134. Helios Hospital Pirna, Pirna, Germany
  135. 135. Internal Medicine II, Department of Infectious Diseases, Freiburg University Hospital, Freiburg, Germany
  136. 136. Department of Cardiology, Northumbria Healthcare NHS Foundation Trust, Newcastle, United Kingdom
  137. 137. Department of Gastroenterology, University Hospital Augsburg, Augsburg, Germany
  138. 138. Robert-Bosch Hospital, Department of Gastroenterology, Hepatology and Endocrinology, Stuttgart, Germany
  139. 139. Sophien- and Hufeland Clinic Weimar, Weimar, Germany
  140. 140. Department of Internal Medicine II, Hematology and Medical Oncology, University Hospital Jena, Jena, Germany
  141. 141. Benha Faculty of Medicine, Benha, Egypt
  142. 142. Department of Nursing, Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  143. 143. Barts National Institute for Health Research (NIHR), Biomedical Research Center, William Harvey Research Institute, Queen Mary University of London, United Kingdom
  144. 144. Department of Cardiology, Slingeland Hospital Doetinchem, Netherlands
  145. 145. Department of Internal Medicine, Hematology and Oncology, Elbland Hospital Riesa, Riesa, Germany
  146. 146. Department of Cardiology, Rijnstate Hospital, Arnhem, Netherlands
  147. 147. Department of Cardiovascular Research, Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  148. 148. Department of Internal Medicine II, School of Medicine, University Hospital Rechts Der Isar, Technical University of Munich, Munich, Germany
  149. 149. Department of Pneumology, Allergy, Sleep and Intensive Care Medicine, Petrus Hospital Wuppertal, University of Witten-Herdecke, Wuppertal, Germany
  150. 150. Department of Medicine I, University Hospital Erlangen, Erlangen, Germany
  151. 151. Department of Cardiology, Catharina Hospital, Eindhoven, Netherlands
  152. 152. Department of Cardiology, University Hospitals of Geneva, Geneva, Switzerland
  153. 153. William Harvey Research Institute, Queen Mary University of London, United Kingdom
  154. 154. Department of Intensive Care Medicine, Royal Free Hospital, Royal Free London NHS Foundation Trust, London, United Kingdom
  155. 155. Department of Cardiology, Heart Center Hasselt, Jessa Hospital, Hasselt, Belgium
  156. 156. Department of Educational Development and Research, The Faculty of Health, Medicine and Life Sciences, Catharina Hospital, Eindhoven, Netherlands
  157. 157. Department of Cardiology, Dijklander Hospital, Hoorn, Netherlands
  158. 158. Department I for Internal Medicine, Faculty of Medicine, University Hospital of Cologne, University of Cologne, Cologne, Germany
  159. 159. Department of Medicine II, Section of Infectious Diseases, Justus-Liebig-University Giessen, The German Lung Center (DZL), Germany
  160. 160. Department of Intensive Care Medicine, Maasstad Hospital, Rotterdam, Netherlands
  161. 161. Cardiovascular Research, Antwerp University and Cardiology, Antwerp University Hospital, Antwerp, Belgium
  162. 162. Department of Pulmonology, Medisch Spectrum Twente, Enschede, Netherlands
  163. 163. Department of Internal Medicine, Infectious Diseases, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt am Main, Germany
  164. 164. Department of Intensive Care, Rode Kruis Hospital, Beverwijk, Netherlands
  165. 165. Department of Intensive Care, Ziekenhuis Groep Twente (ZGT), Almelo, Netherlands
  166. 166. Department of Cardiology, Zaans Medical Center, Zaandam, Netherlands
  167. 167. Elisabeth Hospital Essen, Essen, Germany
  168. 168. Department of Internal Medicine, Antonius Hospital, Sneek, Netherlands
  169. 169. Department of Cardiology, Bernhoven Hospital, Uden, Netherlands
  170. 170. Hospital St. Joseph-Stift Dresden, Dresden, Germany
  171. 171. Department of Cardiology, Albert Schweitzer Hospital, Dordrecht, Netherlands
  172. 172. Department of Cardiology, Rode Kruis Hospital, Beverwijk, Netherlands
  173. 173. Department of Cardiology, Beatrix Hospital, Gorinchem, Netherlands
  174. 174. Medical Department I, Marien Hospital Herne, Ruhr-University, Bochum, Germany
  175. 175. Department of Cardiology, CHVZ, University Hospital Brussels, Jette, Belgium
  176. 176. University of Bochum, University Clinic for Hematology, Oncology, Hemostaseology and Palliative Care, Minden, Germany
  177. 177. Division of Infectious Diseases, University Hospital Carl Gustav Carus, Technical University of Dresden, Dresden, Germany
  178. 178. Oberlausitz Hospital, Germany
  179. 179. Department of Cardiology, Van Weel-Bethesda Hospital, Dirksland, Netherlands
  180. 180. Department of Pulmonology, Ziekenhuis Groep Twente (ZGT), Almelo, Netherlands
  181. 181. Freeman Hospital, Newcastle Upon Tyne NHS Hospitals Foundation Trust, Newcastle University, Newcastle upon Tyne, NE7 7DN, United Kingdom
  182. 182. Department of Cardiology, Northumbria Hospitals NHS Foundation Trust, Newcastle, United Kingdom
  183. 183. Department of Cardiology, Amstelland Hospital, Amstelveen, Netherlands
  184. 184. Research Department, Bernhoven Hospital, Uden, Netherlands
  185. 185. Department of Cardiology, One Day Surgery Hospital, Cairo, Egypt
  186. 186. COVID-19 Unit, SSR Val Rosay, Saint Didier au Mont d'Or, France
  187. 187. Department of Cardiology, Functional and and Ultrasound Diagnostics of N.V. Sklifosovsky Institute for Clinical Medicine, I.M. Sechenov First Moscow State Medical University, Sechenov University, Moscow, Russian Federation
  188. 188. Department of Emergency, Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  189. 189. Department of Rheumatology and Clinical Immunology, Medisch Spectrum Twente, Enschede, Netherlands

Source: European Heart Journal Published:2022


Abstract

Aims Patients with cardiac disease are considered high risk for poor outcomes following hospitalization with COVID-19. The primary aim of this study was to evaluate heterogeneity in associations between various heart disease subtypes and in-hospital mortality. Methods and results We used data from the CAPACITY-COVID registry and LEOSS study. Multivariable Poisson regression models were fitted to assess the association between different types of pre-existing heart disease and in-hospital mortality. A total of 16 511 patients with COVID-19 were included (21.1% aged 66-75 years; 40.2% female) and 31.5% had a history of heart disease. Patients with heart disease were older, predominantly male, and often had other comorbid conditions when compared with those without. Mortality was higher in patients with cardiac disease (29.7%; n = 1545 vs. 15.9%; n = 1797). However, following multivariable adjustment, this difference was not significant [adjusted risk ratio (aRR) 1.08, 95% confidence interval (CI) 1.02-1.15; P = 0.12 (corrected for multiple testing)]. Associations with in-hospital mortality by heart disease subtypes differed considerably, with the strongest association for heart failure (aRR 1.19, 95% CI 1.10-1.30; P < 0.018) particularly for severe (New York Heart Association class III/IV) heart failure (aRR 1.41, 95% CI 1.20-1.64; P < 0.018). None of the other heart disease subtypes, including ischaemic heart disease, remained significant after multivariable adjustment. Serious cardiac complications were diagnosed in <1% of patients. Conclusion Considerable heterogeneity exists in the strength of association between heart disease subtypes and in-hospital mortality. Of all patients with heart disease, those with heart failure are at greatest risk of death when hospitalized with COVID-19. Serious cardiac complications are rare during hospitalization. © The Author(s) 2021
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