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In Patients Suffering From Major Depressive Disorders, Quantitative Eeg Showed Favorable Changes in Left and Right Prefrontal Cortex Publisher Pubmed



Haghighi M1 ; Ludyga S2 ; Rahimi B1 ; Jahangard L1 ; Ahmadpanah M1 ; Torabian S3 ; Esnaashari F3 ; Nazaribadie M1 ; Bajoghli H4 ; Sadeghi Bahmani D5 ; Holsboertrachsler E5 ; Brand S2, 5
Authors
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Authors Affiliations
  1. 1. Research Center for Behavioral Disorders and Substance Abuse, Hamadan University of Medial Sciences, Hamadan, Iran
  2. 2. University of Basel, Department of Sport, Exercise, and Health, Division of Sport Science and Psychosocial Health, Basel, Switzerland
  3. 3. Department of Community Medicine, School of Medicine, Hamadan University of Medical Sciences, Hamadam, Iran
  4. 4. Iranian National Center for Addiction Studies (INCAS), Tehran University of Medical Sciences, Tehran, Iran
  5. 5. University of Basel, Psychiatric Clinics (UPK), Center for Affective, Stress and Sleep Disorders (ZASS), Basel, Switzerland

Source: Psychiatry Research Published:2017


Abstract

Background Patients suffering from major depressive disorders (MDD) report anhedonia, low concentration and lack of goal-oriented behavior. Data from imaging and quantitative EEG (QEEG) studies show an asymmetry in the prefrontal cortex (PFC), with lower left as compared to right PFC-activity, associated with specific depression-related behavior. Cordance is a QEEG measurement, which combines absolute and relative power of EEG-spectra with strong correlations with regional perfusion. The aim of the present study was to investigate to what extent a four weeks lasting treatment with a standard SSRI had an influence on neuronal activation and MDD-related symptoms. Method Twenty patients suffering from severe MDD were treated with citalopram (40 mg) for four consecutive weeks. At baseline and at the end of the treatment, patients underwent QEEG. Experts rated the degree of depression with the Hamilton Depression Rating Scale (HDRS). Results Over time, theta cordance increased over right ventromedial and left dorsolateral PFC, whereas alpha cordance decreased over dorsolateral PFC. Improvement in MDD-related symptoms was higher in patients showing decreased EEG theta cordance over right dorsal PFC and increased EEG alpha cordance over left dorsolateral PFC. Conclusions In patients suffering from MDD, treatment response was associated with favorable changes in neuronal activity. © 2017 Elsevier Ireland Ltd
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