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Recent Advancements in Aptamer-Bioconjugates: Sharpening Stones for Breast and Prostate Cancers Targeting Publisher



Maghsoudi S1 ; Shahraki BT1 ; Rabiee N2, 3, 4 ; Afshari R3, 4, 5 ; Fatahi Y6, 7, 8 ; Dinarvand R6, 7 ; Ahmadi S3, 4, 9 ; Bagherzadeh M2 ; Rabiee M10 ; Tahriri M11 ; Tayebi L11
Authors
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Authors Affiliations
  1. 1. Department of Medicinal Chemistry, Shiraz University of Technology, Shiraz, 71555-313, Iran
  2. 2. Department of Chemistry, Sharif University of Technology, Tehran, Iran
  3. 3. Division of Chemistry, Advanced Technologies Research Group, Tehran, Iran
  4. 4. Division of Diaseses, Advanced Technologies Research Group, Tehran, Iran
  5. 5. Department of Chemistry, Shahid Beheshti University, Tehran, Iran
  6. 6. Department of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Universal Scientific Education and Research Network (USERN), Tehran, Iran
  9. 9. Student Research Committee, Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  10. 10. Biomaterial Group, Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran
  11. 11. Department of Developmental Sciences, Marquette University, Milwaukee, 53233, WI, United States

Source: Journal of Drug Delivery Science and Technology Published:2019


Abstract

Breast and prostate cancers are common types of cancers with various strategies, such as chemotherapy and radiotherapy, for their therapy. Since these methods have undesired side effects and poor target affinity, neoteric strategies—known as aptamer-based smart drug delivery systems (SDDSs)—have been developed in recent years to overcome the obstacles of current treatment, and investigated for a clinical trial. The high affinity and versatility of aptamers for binding to the corresponding targets make them highly noticeable agents in the drug delivery domains. In addition to their exceptional benefits, aptamers are able to overcome tumor resistance because of their high selectivity and low toxicity. Furthermore, aptamers can conjugate with various drugs, nanoparticles and antibodies and effectively deliver them to the specific breast and prostate cells. This review highlights the current researches in aptamer-conjugate developments for targeting breast and prostate cancers, with the special focus on the nanoparticle-aptamer bioconjugates, systematic evolution of ligands by exponential enrichment (SELEX) system and SDDS, especially cutting-edge articles from 2008 to present. Finally, the future prospects and challenges are described. © 2019
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