What We Need to Know About Liposomes As Drug Nanocarriers: An Updated Review Publisher



Abbasi H^{1, 2} ; Kouchak M^{2, 3} ; Mirveis Z^{1, 2} ; Hajipour F¹ ; Khodarahmi M^{1, 2} ; Rahbar N² ; Handali S⁴ Show Affiliations
Source: Advanced Pharmaceutical Bulletin Published:2023

Abstract

Liposomes have been attracted considerable attention as phospholipid spherical vesicles, over the past 40 years. These lipid vesicles are valued in biomedical application due to their ability to carry both hydrophobic and hydrophilic agents, high biocompatibility and biodegradability. Until now, various methods have been used for the synthesis of liposomes and the numerous modifications have been performed to improve liposomes characteristics such as surface charge, size, number of their layers, and length of circulation in biological fluids. This article provides an overview of the significant advances in synthesis of liposomes via active or passive drug loading methods, as well as describes some strategies developed to fabricate their targeted formulations to overcome limitations of the “first-generation” liposomes. © 2023 The Author (s).