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Association of Apolipoprotein E Gene Polymorphism With Preeclampsia: A Meta-Analysis Publisher Pubmed



Abyadeh M1 ; Heydarinejad F2 ; Khakpash M2 ; Asefi Y3 ; Shabbidar S4
Authors
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Authors Affiliations
  1. 1. Department of Molecular Systems Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran
  2. 2. Department of Nursing, School of Nursing and Midwifery, Shahroud University of Medical Sciences, Shahroud, Iran
  3. 3. Department of Genetics, Ahar Branch, Islamic Azad University, Ahar, Iran
  4. 4. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran

Source: Hypertension in Pregnancy Published:2020


Abstract

Objective: The aim of this meta-analysis was to examine the association of ApoE polymorphism with the risk of developing PE. Methods: A comprehensive search was carried out through PubMed, Scopus, and Embase. The ORs with corresponding 95% CIs were extracted. Fixed model was used for meta-analysis and in case of existing heterogeneity a random-effects model was applied. Results: Association of ApoE polymorphism with the risk of developing PE was not statistically significant (OR = 0.86, 95% CI: 0.67–1.11; OR = 0.92, 95%CI: 0.73–1.15, respectively for ε2 and ε4). Conclusion: ApoE polymorphism might not be associated with the risk of PE. © 2020, © 2020 Informa UK Limited, trading as Taylor & Francis Group.
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