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Association of Apolipoprotein E Gene Polymorphism With Preeclampsia: A Meta-Analysis Publisher Pubmed



Abyadeh M1 ; Heydarinejad F2 ; Khakpash M2 ; Asefi Y3 ; Shabbidar S4
Authors

Source: Hypertension in Pregnancy Published:2020


Abstract

Objective: The aim of this meta-analysis was to examine the association of ApoE polymorphism with the risk of developing PE. Methods: A comprehensive search was carried out through PubMed, Scopus, and Embase. The ORs with corresponding 95% CIs were extracted. Fixed model was used for meta-analysis and in case of existing heterogeneity a random-effects model was applied. Results: Association of ApoE polymorphism with the risk of developing PE was not statistically significant (OR = 0.86, 95% CI: 0.67–1.11; OR = 0.92, 95%CI: 0.73–1.15, respectively for ε2 and ε4). Conclusion: ApoE polymorphism might not be associated with the risk of PE. © 2020, © 2020 Informa UK Limited, trading as Taylor & Francis Group.
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