Systematic Review and Meta-Analytic Findings on the Association Between Killer-Cell Immunoglobulin-Like Receptor Genes and Susceptibility to Pulmonary Tuberculosis

Systematic Review and Meta-Analytic Findings on the Association Between Killer-Cell Immunoglobulin-Like Receptor Genes and Susceptibility to Pulmonary Tuberculosis Publisher Pubmed

Omraninava M¹ ; Mehranfar S^{2, 3} ; Khosrojerdi A⁴ ; Jamalzehi S⁵ ; Karami J⁶ ; Motallebnezhad M⁶ ; Javan MR⁷ ; Aslani S⁸ ; Mohammadi H⁹ ; Kousha A¹⁰

Show Affiliations

1. Department of Infectious Disease, Faculty of Medical Sciences, Sari Branch, Islamic Azad University, Sari, Iran
2. Department of Genetics and Immunology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran
3. Cellular and Molecular Research Center, Urmia University of Medical Sciences, Urmia, Iran
4. Department of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
5. Department of Medical Laboratory Sciences, Iranshahr University of Medical Sciences, Iranshahr, Iran
6. Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
7. Department of Immunology, Faculty of Medicine, Zabol University of Medical Sciences, Zabol, Iran
8. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
9. Department of Immunology, School of Medicine, Alborz University of Medical Sciences, Alborz, Iran
10. Department of Health Education and Health Promotion, Faculty of Health, Tabriz University of Medical Sciences, Tabriz, Iran

Source: Pathogens and Global Health Published:2021

Abstract

Several studies have evaluated the association between killer-cell immunoglobulin-like receptors (KIR) genes and susceptibility risk to tuberculosis (TB) infection. Nonetheless, their outcomes have not been conclusive and consistent. Here we implemented a systematic review and meta-analysis of KIR genes association to susceptibility risk of pulmonary TB (PTB) infection to attain a clear understanding of the involvement of these genes in susceptibility to PTB infection. A systematic search was conducted in the MEDLINE/PubMed and Scopus databases to find case-control studies published before November 2020. Pooled odds ratio (OR) and 95% confidence interval (95% CI) were calculated to determine the association between KIR genes and risk of PTB infection. After comprehensive searching and implementing the inclusion and exclusion criteria, 10 case-control studies were included in the meta-analysis. Four KIR genes were found to have significant positive association with PTB susceptibility risk of infection, including 2DL3 (OR = 1.454, 95% CI = 1.157–1.827; P = 0.001), 2DS1 (OR = 1.481, 95% CI = 1.334–1.837; P < 0.001), 2DS4 (OR = 1.782, 95% CI = 1.273–2.495; P = 0.001) and 3DL1 (OR = 1.726, 95% CI = 1.277–2.333; P < 0.001). However, the results showed that the remaining KIR genes (2DS2-4, 2DL1, 2, 4, 3DL1-2) and two pseudogenes (2DP1 and 3DP1) did not have significant associations with risk of PTB infection. This meta-analysis provides reliable evidence that the KIR genes 2DL3, 2DS1, 2DS4, and 3DL1 may be associated with an increased risk of PTB infection. © 2020 Informa UK Limited, trading as Taylor & Francis Group.

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Style	Citing Format
MLA	Omraninava M, et al.. "Systematic Review and Meta-Analytic Findings on the Association Between Killer-Cell Immunoglobulin-Like Receptor Genes and Susceptibility to Pulmonary Tuberculosis." Pathogens and Global Health, vol. 115, no. 1, 2021, pp. 61-69.
APA	Omraninava M, Mehranfar S, Khosrojerdi A, Jamalzehi S, Karami J, Motallebnezhad M, Javan MR, Aslani S, Mohammadi H, Kousha A (2021). Systematic Review and Meta-Analytic Findings on the Association Between Killer-Cell Immunoglobulin-Like Receptor Genes and Susceptibility to Pulmonary Tuberculosis. Pathogens and Global Health, 115(1), 61-69.
Chicago	Omraninava M, Mehranfar S, Khosrojerdi A, Jamalzehi S, Karami J, Motallebnezhad M, Javan MR, Aslani S, Mohammadi H, Kousha A. "Systematic Review and Meta-Analytic Findings on the Association Between Killer-Cell Immunoglobulin-Like Receptor Genes and Susceptibility to Pulmonary Tuberculosis." Pathogens and Global Health 115, no. 1 (2021): 61-69.
Harvard	Omraninava M et al. (2021) 'Systematic Review and Meta-Analytic Findings on the Association Between Killer-Cell Immunoglobulin-Like Receptor Genes and Susceptibility to Pulmonary Tuberculosis', Pathogens and Global Health, 115(1), pp. 61-69.
Vancouver	Omraninava M, Mehranfar S, Khosrojerdi A, Jamalzehi S, Karami J, Motallebnezhad M, et al.. Systematic Review and Meta-Analytic Findings on the Association Between Killer-Cell Immunoglobulin-Like Receptor Genes and Susceptibility to Pulmonary Tuberculosis. Pathogens and Global Health. 2021;115(1):61-69.
BibTex	@article{ author = {Omraninava M and Mehranfar S and Khosrojerdi A and Jamalzehi S and Karami J and Motallebnezhad M and Javan MR and Aslani S and Mohammadi H and Kousha A}, title = {Systematic Review and Meta-Analytic Findings on the Association Between Killer-Cell Immunoglobulin-Like Receptor Genes and Susceptibility to Pulmonary Tuberculosis}, journal = {Pathogens and Global Health}, volume = {115}, number = {1}, pages = {61-69}, year = {2021} }
RIS	TY - JOUR AU - Omraninava M AU - Mehranfar S AU - Khosrojerdi A AU - Jamalzehi S AU - Karami J AU - Motallebnezhad M AU - Javan MR AU - Aslani S AU - Mohammadi H AU - Kousha A TI - Systematic Review and Meta-Analytic Findings on the Association Between Killer-Cell Immunoglobulin-Like Receptor Genes and Susceptibility to Pulmonary Tuberculosis JO - Pathogens and Global Health VL - 115 IS - 1 SP - 61 EP - 69 PY - 2021 ER -

Style

Citing Format

MLA

Omraninava M, et al.. "Systematic Review and Meta-Analytic Findings on the Association Between Killer-Cell Immunoglobulin-Like Receptor Genes and Susceptibility to Pulmonary Tuberculosis." Pathogens and Global Health, vol. 115, no. 1, 2021, pp. 61-69.

APA

Omraninava M, Mehranfar S, Khosrojerdi A, Jamalzehi S, Karami J, Motallebnezhad M, Javan MR, Aslani S, Mohammadi H, Kousha A (2021). Systematic Review and Meta-Analytic Findings on the Association Between Killer-Cell Immunoglobulin-Like Receptor Genes and Susceptibility to Pulmonary Tuberculosis. Pathogens and Global Health, 115(1), 61-69.

Chicago

Omraninava M, Mehranfar S, Khosrojerdi A, Jamalzehi S, Karami J, Motallebnezhad M, Javan MR, Aslani S, Mohammadi H, Kousha A. "Systematic Review and Meta-Analytic Findings on the Association Between Killer-Cell Immunoglobulin-Like Receptor Genes and Susceptibility to Pulmonary Tuberculosis." Pathogens and Global Health 115, no. 1 (2021): 61-69.

Harvard

Omraninava M et al. (2021) 'Systematic Review and Meta-Analytic Findings on the Association Between Killer-Cell Immunoglobulin-Like Receptor Genes and Susceptibility to Pulmonary Tuberculosis', Pathogens and Global Health, 115(1), pp. 61-69.

Vancouver

Omraninava M, Mehranfar S, Khosrojerdi A, Jamalzehi S, Karami J, Motallebnezhad M, et al.. Systematic Review and Meta-Analytic Findings on the Association Between Killer-Cell Immunoglobulin-Like Receptor Genes and Susceptibility to Pulmonary Tuberculosis. Pathogens and Global Health. 2021;115(1):61-69.

BibTex

@article{ author = {Omraninava M and Mehranfar S and Khosrojerdi A and Jamalzehi S and Karami J and Motallebnezhad M and Javan MR and Aslani S and Mohammadi H and Kousha A}, title = {Systematic Review and Meta-Analytic Findings on the Association Between Killer-Cell Immunoglobulin-Like Receptor Genes and Susceptibility to Pulmonary Tuberculosis}, journal = {Pathogens and Global Health}, volume = {115}, number = {1}, pages = {61-69}, year = {2021} }

RIS

TY - JOUR
AU - Omraninava M
AU - Mehranfar S
AU - Khosrojerdi A
AU - Jamalzehi S
AU - Karami J
AU - Motallebnezhad M
AU - Javan MR
AU - Aslani S
AU - Mohammadi H
AU - Kousha A
TI - Systematic Review and Meta-Analytic Findings on the Association Between Killer-Cell Immunoglobulin-Like Receptor Genes and Susceptibility to Pulmonary Tuberculosis
JO - Pathogens and Global Health
VL - 115
IS - 1
SP - 61
EP - 69
PY - 2021
ER -

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