Synthesis and Biological Evaluation of a New Series of Benzofuran-1,3,4-Oxadiazole Containing 1,2,3-Triazole-Acetamides As Potential Α-Glucosidase Inhibitors

Synthesis and Biological Evaluation of a New Series of Benzofuran-1,3,4-Oxadiazole Containing 1,2,3-Triazole-Acetamides As Potential Α-Glucosidase Inhibitors Publisher Pubmed

Abedinifar F¹ ; Mohammadikhanaposhtani M² ; Asemanipoor N¹ ; Mojtabavi S³ ; Faramarzi MA³ ; Mahdavi M¹ ; Biglar M¹ ; Larijani B¹ ; Hamedifar H⁴ ; Hajimiri MH⁵

Show Affiliations

1. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
2. Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
3. Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
4. CinnaGen Medical Biotechnology Research Center, Alborz University of Medical Sciences, Karaj, Iran
5. Nano Alvand Company, Avicenna Tech Park, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Biochemical and Molecular Toxicology Published:2021

Abstract

A series of new benzofuran-1,3,4-oxadiazole containing 1,2,3-triazole-acetamides 12a-n as potential anti-α-glucosidase agents were designed and synthesized. α-Glucosidase inhibition assay demonstrated that all the synthesized compounds 12a-n (half-maximal inhibitory concentration [IC50] values in the range of 40.7 ± 0.3–173.6 ± 1.9 μM) were more potent than standard inhibitor acarbose (IC50 = 750.0 ± 12.5 µM). Among them, the most potent compound was compound 12c, with inhibitory activity around 19-fold higher than acarbose. Since the most potent compound inhibited α-glucosidase in a competitive mode, a docking study of this compound was also performed into the active site of α-glucosidase. In vitro and in silico toxicity assays of the title compounds were also performed. © 2020 Wiley Periodicals LLC

Style	Citing Format
MLA	Abedinifar F, et al.. "Synthesis and Biological Evaluation of a New Series of Benzofuran-1,3,4-Oxadiazole Containing 1,2,3-Triazole-Acetamides As Potential Α-Glucosidase Inhibitors." Journal of Biochemical and Molecular Toxicology, vol. 35, no. 4, 2021, pp. -.
APA	Abedinifar F, Mohammadikhanaposhtani M, Asemanipoor N, Mojtabavi S, Faramarzi MA, Mahdavi M, Biglar M, Larijani B, Hamedifar H, Hajimiri MH (2021). Synthesis and Biological Evaluation of a New Series of Benzofuran-1,3,4-Oxadiazole Containing 1,2,3-Triazole-Acetamides As Potential Α-Glucosidase Inhibitors. Journal of Biochemical and Molecular Toxicology, 35(4), -.
Chicago	Abedinifar F, Mohammadikhanaposhtani M, Asemanipoor N, Mojtabavi S, Faramarzi MA, Mahdavi M, Biglar M, Larijani B, Hamedifar H, Hajimiri MH. "Synthesis and Biological Evaluation of a New Series of Benzofuran-1,3,4-Oxadiazole Containing 1,2,3-Triazole-Acetamides As Potential Α-Glucosidase Inhibitors." Journal of Biochemical and Molecular Toxicology 35, no. 4 (2021): -.
Harvard	Abedinifar F et al. (2021) 'Synthesis and Biological Evaluation of a New Series of Benzofuran-1,3,4-Oxadiazole Containing 1,2,3-Triazole-Acetamides As Potential Α-Glucosidase Inhibitors', Journal of Biochemical and Molecular Toxicology, 35(4), pp. -.
Vancouver	Abedinifar F, Mohammadikhanaposhtani M, Asemanipoor N, Mojtabavi S, Faramarzi MA, Mahdavi M, et al.. Synthesis and Biological Evaluation of a New Series of Benzofuran-1,3,4-Oxadiazole Containing 1,2,3-Triazole-Acetamides As Potential Α-Glucosidase Inhibitors. Journal of Biochemical and Molecular Toxicology. 2021;35(4):-.
BibTex	@article{ author = {Abedinifar F and Mohammadikhanaposhtani M and Asemanipoor N and Mojtabavi S and Faramarzi MA and Mahdavi M and Biglar M and Larijani B and Hamedifar H and Hajimiri MH}, title = {Synthesis and Biological Evaluation of a New Series of Benzofuran-1,3,4-Oxadiazole Containing 1,2,3-Triazole-Acetamides As Potential Α-Glucosidase Inhibitors}, journal = {Journal of Biochemical and Molecular Toxicology}, volume = {35}, number = {4}, pages = {-}, year = {2021} }
RIS	TY - JOUR AU - Abedinifar F AU - Mohammadikhanaposhtani M AU - Asemanipoor N AU - Mojtabavi S AU - Faramarzi MA AU - Mahdavi M AU - Biglar M AU - Larijani B AU - Hamedifar H AU - Hajimiri MH TI - Synthesis and Biological Evaluation of a New Series of Benzofuran-1,3,4-Oxadiazole Containing 1,2,3-Triazole-Acetamides As Potential Α-Glucosidase Inhibitors JO - Journal of Biochemical and Molecular Toxicology VL - 35 IS - 4 SP - EP - PY - 2021 ER -

Style

Citing Format

MLA

Abedinifar F, et al.. "Synthesis and Biological Evaluation of a New Series of Benzofuran-1,3,4-Oxadiazole Containing 1,2,3-Triazole-Acetamides As Potential Α-Glucosidase Inhibitors." Journal of Biochemical and Molecular Toxicology, vol. 35, no. 4, 2021, pp. -.

APA

Abedinifar F, Mohammadikhanaposhtani M, Asemanipoor N, Mojtabavi S, Faramarzi MA, Mahdavi M, Biglar M, Larijani B, Hamedifar H, Hajimiri MH (2021). Synthesis and Biological Evaluation of a New Series of Benzofuran-1,3,4-Oxadiazole Containing 1,2,3-Triazole-Acetamides As Potential Α-Glucosidase Inhibitors. Journal of Biochemical and Molecular Toxicology, 35(4), -.

Chicago

Abedinifar F, Mohammadikhanaposhtani M, Asemanipoor N, Mojtabavi S, Faramarzi MA, Mahdavi M, Biglar M, Larijani B, Hamedifar H, Hajimiri MH. "Synthesis and Biological Evaluation of a New Series of Benzofuran-1,3,4-Oxadiazole Containing 1,2,3-Triazole-Acetamides As Potential Α-Glucosidase Inhibitors." Journal of Biochemical and Molecular Toxicology 35, no. 4 (2021): -.

Harvard

Abedinifar F et al. (2021) 'Synthesis and Biological Evaluation of a New Series of Benzofuran-1,3,4-Oxadiazole Containing 1,2,3-Triazole-Acetamides As Potential Α-Glucosidase Inhibitors', Journal of Biochemical and Molecular Toxicology, 35(4), pp. -.

Vancouver

Abedinifar F, Mohammadikhanaposhtani M, Asemanipoor N, Mojtabavi S, Faramarzi MA, Mahdavi M, et al.. Synthesis and Biological Evaluation of a New Series of Benzofuran-1,3,4-Oxadiazole Containing 1,2,3-Triazole-Acetamides As Potential Α-Glucosidase Inhibitors. Journal of Biochemical and Molecular Toxicology. 2021;35(4):-.

BibTex

@article{ author = {Abedinifar F and Mohammadikhanaposhtani M and Asemanipoor N and Mojtabavi S and Faramarzi MA and Mahdavi M and Biglar M and Larijani B and Hamedifar H and Hajimiri MH}, title = {Synthesis and Biological Evaluation of a New Series of Benzofuran-1,3,4-Oxadiazole Containing 1,2,3-Triazole-Acetamides As Potential Α-Glucosidase Inhibitors}, journal = {Journal of Biochemical and Molecular Toxicology}, volume = {35}, number = {4}, pages = {-}, year = {2021} }

RIS

TY - JOUR
AU - Abedinifar F
AU - Mohammadikhanaposhtani M
AU - Asemanipoor N
AU - Mojtabavi S
AU - Faramarzi MA
AU - Mahdavi M
AU - Biglar M
AU - Larijani B
AU - Hamedifar H
AU - Hajimiri MH
TI - Synthesis and Biological Evaluation of a New Series of Benzofuran-1,3,4-Oxadiazole Containing 1,2,3-Triazole-Acetamides As Potential Α-Glucosidase Inhibitors
JO - Journal of Biochemical and Molecular Toxicology
VL - 35
IS - 4
SP -
EP -
PY - 2021
ER -

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Abstract