A New Series of Schiff Base Derivatives Bearing 1,2,3-Triazole: Design, Synthesis, Molecular Docking, and Α-Glucosidase Inhibition

A New Series of Schiff Base Derivatives Bearing 1,2,3-Triazole: Design, Synthesis, Molecular Docking, and Α-Glucosidase Inhibition Publisher Pubmed

Nasliesfahani E¹ ; Mohammadikhanaposhtani M² ; Rezaei S³ ; Sarrafi Y⁴ ; Sharafi Z⁵ ; Samadi N⁶ ; Faramarzi MA⁶ ; Bandarian F¹ ; Hamedifar H⁷ ; Larijani B⁸ ; Hajimiri M⁹ ; Mahdavi M⁸

Source: Archiv der Pharmazie Published:2019

Abstract

A series of new Schiff bases bearing 1,2,3-triazole 12a‒o was designed, synthesized, and evaluated as α-glucosidase inhibitors. All the synthesized compounds showed promising inhibition against α-glucosidase and were more potent than the standard drug acarbose. The kinetic study on the most potent compound 12n showed that this compound acted as a competitive α-glucosidase inhibitor. The docking study revealed that the synthesized compounds interacted with the important residues in the active site of α-glucosidase. © 2019 Deutsche Pharmazeutische Gesellschaft

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Mohammad Ali Faramarzi (20)

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Style	Citing Format
MLA	Nasliesfahani E, et al.. "A New Series of Schiff Base Derivatives Bearing 1,2,3-Triazole: Design, Synthesis, Molecular Docking, and Α-Glucosidase Inhibition." Archiv der Pharmazie, vol. 352, no. 8, 2019, pp. -.
APA	Nasliesfahani E, Mohammadikhanaposhtani M, Rezaei S, Sarrafi Y, Sharafi Z, Samadi N, Faramarzi MA, Bandarian F, Hamedifar H, Larijani B, Hajimiri M, Mahdavi M (2019). A New Series of Schiff Base Derivatives Bearing 1,2,3-Triazole: Design, Synthesis, Molecular Docking, and Α-Glucosidase Inhibition. Archiv der Pharmazie, 352(8), -.
Chicago	Nasliesfahani E, Mohammadikhanaposhtani M, Rezaei S, Sarrafi Y, Sharafi Z, Samadi N, Faramarzi MA, et al.. "A New Series of Schiff Base Derivatives Bearing 1,2,3-Triazole: Design, Synthesis, Molecular Docking, and Α-Glucosidase Inhibition." Archiv der Pharmazie 352, no. 8 (2019): -.
Harvard	Nasliesfahani E et al. (2019) 'A New Series of Schiff Base Derivatives Bearing 1,2,3-Triazole: Design, Synthesis, Molecular Docking, and Α-Glucosidase Inhibition', Archiv der Pharmazie, 352(8), pp. -.
Vancouver	Nasliesfahani E, Mohammadikhanaposhtani M, Rezaei S, Sarrafi Y, Sharafi Z, Samadi N, et al.. A New Series of Schiff Base Derivatives Bearing 1,2,3-Triazole: Design, Synthesis, Molecular Docking, and Α-Glucosidase Inhibition. Archiv der Pharmazie. 2019;352(8):-.
BibTex	@article{ author = {Nasliesfahani E and Mohammadikhanaposhtani M and Rezaei S and Sarrafi Y and Sharafi Z and Samadi N and Faramarzi MA and Bandarian F and Hamedifar H and Larijani B and Hajimiri M and Mahdavi M}, title = {A New Series of Schiff Base Derivatives Bearing 1,2,3-Triazole: Design, Synthesis, Molecular Docking, and Α-Glucosidase Inhibition}, journal = {Archiv der Pharmazie}, volume = {352}, number = {8}, pages = {-}, year = {2019} }
RIS	TY - JOUR AU - Nasliesfahani E AU - Mohammadikhanaposhtani M AU - Rezaei S AU - Sarrafi Y AU - Sharafi Z AU - Samadi N AU - Faramarzi MA AU - Bandarian F AU - Hamedifar H AU - Larijani B AU - Hajimiri M AU - Mahdavi M TI - A New Series of Schiff Base Derivatives Bearing 1,2,3-Triazole: Design, Synthesis, Molecular Docking, and Α-Glucosidase Inhibition JO - Archiv der Pharmazie VL - 352 IS - 8 SP - EP - PY - 2019 ER -

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