A New Series of Schiff Base Derivatives Bearing 1,2,3-Triazole: Design, Synthesis, Molecular Docking, and Α-Glucosidase Inhibition

A New Series of Schiff Base Derivatives Bearing 1,2,3-Triazole: Design, Synthesis, Molecular Docking, and Α-Glucosidase Inhibition Publisher Pubmed

Nasliesfahani E¹ ; Mohammadikhanaposhtani M² ; Rezaei S³ ; Sarrafi Y⁴ ; Sharafi Z⁵ ; Samadi N⁶ ; Faramarzi MA⁶ ; Bandarian F¹ ; Hamedifar H⁷ ; Larijani B⁸ ; Hajimiri M⁹ ; Mahdavi M⁸

Show Affiliations

1. Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
2. Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
3. School of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
4. Faculty of Chemistry, University of Mazandaran, Babolsar, Iran
5. Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran
6. Department of Pharmaceutical Biotechnology, Faculty of Pharmacy and Biotechnology Research Center, Tehran University of Medical Sciences, Tehran, Iran
7. CinnaGen Medical Biotechnology Research Center, Alborz University of Medical Sciences, Karaj, Iran
8. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
9. Nano Alvand Company, Avicenna Tech Park, Tehran University of Medical Sciences, Tehran, Iran

Source: Archiv der Pharmazie Published:2019

Abstract

A series of new Schiff bases bearing 1,2,3-triazole 12a‒o was designed, synthesized, and evaluated as α-glucosidase inhibitors. All the synthesized compounds showed promising inhibition against α-glucosidase and were more potent than the standard drug acarbose. The kinetic study on the most potent compound 12n showed that this compound acted as a competitive α-glucosidase inhibitor. The docking study revealed that the synthesized compounds interacted with the important residues in the active site of α-glucosidase. © 2019 Deutsche Pharmazeutische Gesellschaft

Style	Citing Format
MLA	Nasliesfahani E, et al.. "A New Series of Schiff Base Derivatives Bearing 1,2,3-Triazole: Design, Synthesis, Molecular Docking, and Α-Glucosidase Inhibition." Archiv der Pharmazie, vol. 352, no. 8, 2019, pp. -.
APA	Nasliesfahani E, Mohammadikhanaposhtani M, Rezaei S, Sarrafi Y, Sharafi Z, Samadi N, Faramarzi MA, Bandarian F, Hamedifar H, Larijani B, Hajimiri M, Mahdavi M (2019). A New Series of Schiff Base Derivatives Bearing 1,2,3-Triazole: Design, Synthesis, Molecular Docking, and Α-Glucosidase Inhibition. Archiv der Pharmazie, 352(8), -.
Chicago	Nasliesfahani E, Mohammadikhanaposhtani M, Rezaei S, Sarrafi Y, Sharafi Z, Samadi N, Faramarzi MA, et al.. "A New Series of Schiff Base Derivatives Bearing 1,2,3-Triazole: Design, Synthesis, Molecular Docking, and Α-Glucosidase Inhibition." Archiv der Pharmazie 352, no. 8 (2019): -.
Harvard	Nasliesfahani E et al. (2019) 'A New Series of Schiff Base Derivatives Bearing 1,2,3-Triazole: Design, Synthesis, Molecular Docking, and Α-Glucosidase Inhibition', Archiv der Pharmazie, 352(8), pp. -.
Vancouver	Nasliesfahani E, Mohammadikhanaposhtani M, Rezaei S, Sarrafi Y, Sharafi Z, Samadi N, et al.. A New Series of Schiff Base Derivatives Bearing 1,2,3-Triazole: Design, Synthesis, Molecular Docking, and Α-Glucosidase Inhibition. Archiv der Pharmazie. 2019;352(8):-.
BibTex	@article{ author = {Nasliesfahani E and Mohammadikhanaposhtani M and Rezaei S and Sarrafi Y and Sharafi Z and Samadi N and Faramarzi MA and Bandarian F and Hamedifar H and Larijani B and Hajimiri M and Mahdavi M}, title = {A New Series of Schiff Base Derivatives Bearing 1,2,3-Triazole: Design, Synthesis, Molecular Docking, and Α-Glucosidase Inhibition}, journal = {Archiv der Pharmazie}, volume = {352}, number = {8}, pages = {-}, year = {2019} }
RIS	TY - JOUR AU - Nasliesfahani E AU - Mohammadikhanaposhtani M AU - Rezaei S AU - Sarrafi Y AU - Sharafi Z AU - Samadi N AU - Faramarzi MA AU - Bandarian F AU - Hamedifar H AU - Larijani B AU - Hajimiri M AU - Mahdavi M TI - A New Series of Schiff Base Derivatives Bearing 1,2,3-Triazole: Design, Synthesis, Molecular Docking, and Α-Glucosidase Inhibition JO - Archiv der Pharmazie VL - 352 IS - 8 SP - EP - PY - 2019 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract