Effect of Vitamin D Supplementation on Thioredoxin Binding Protein 2 Gene Expression in Patients With Diabetes Type 2

Effect of Vitamin D Supplementation on Thioredoxin Binding Protein 2 Gene Expression in Patients With Diabetes Type 2

Rad EY¹ ; Attar MJH² ; Koohdani F¹ ; Sabooryaraghi AA¹ ; Eshraghian MR³ ; Javanbakht MH¹ ; Saboori S¹ ; Chamari M¹ ; And MZ¹ ; Djalali M¹

Show Affiliations

1. Cellular and Molecular Nutrition Department, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
3. Department of Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Source: Current Topics in Nutraceutical Research Published:2015

Abstract

Diabetes type 2 is an oxidative stress related disease. This randomized controlled trial was done to evaluate the effect of vitamin D supplementation on thioredoxin binding protein 2 (TBP-2) gene expression in patients with type 2 diabetes. Subjects of this study consist of 28 patients with type 2 diabetes who received 100μg (4000IU) vitamin D and 30 diabetic patients who received placebo for two months. The effect of vitamin D on gene expression of TBP-2 in PBMC cells was measured by RT-PCR at the beginning and at the end of the study. The results of this study showed no significant differences in TBP-2 gene expression between 2 groups, but a significant decrease in serum TBP-2 concentration in vitamin D receiving group at the end of supplementation. It seems that vitamin D supplementation has no effect on the TBP-2 gene expression in PBMC cells.

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Experts (# of related papers)

Ghodratollah Panahi (1)

Mohammad Hassan Javanbakht (1)

Style	Citing Format
MLA	Rad EY, et al.. "Effect of Vitamin D Supplementation on Thioredoxin Binding Protein 2 Gene Expression in Patients With Diabetes Type 2." Current Topics in Nutraceutical Research, vol. 13, no. 1, 2015, pp. 55-60.
APA	Rad EY, Attar MJH, Koohdani F, Sabooryaraghi AA, Eshraghian MR, Javanbakht MH, Saboori S, Chamari M, And MZ, Djalali M (2015). Effect of Vitamin D Supplementation on Thioredoxin Binding Protein 2 Gene Expression in Patients With Diabetes Type 2. Current Topics in Nutraceutical Research, 13(1), 55-60.
Chicago	Rad EY, Attar MJH, Koohdani F, Sabooryaraghi AA, Eshraghian MR, Javanbakht MH, Saboori S, Chamari M, And MZ, Djalali M. "Effect of Vitamin D Supplementation on Thioredoxin Binding Protein 2 Gene Expression in Patients With Diabetes Type 2." Current Topics in Nutraceutical Research 13, no. 1 (2015): 55-60.
Harvard	Rad EY et al. (2015) 'Effect of Vitamin D Supplementation on Thioredoxin Binding Protein 2 Gene Expression in Patients With Diabetes Type 2', Current Topics in Nutraceutical Research, 13(1), pp. 55-60.
Vancouver	Rad EY, Attar MJH, Koohdani F, Sabooryaraghi AA, Eshraghian MR, Javanbakht MH, et al.. Effect of Vitamin D Supplementation on Thioredoxin Binding Protein 2 Gene Expression in Patients With Diabetes Type 2. Current Topics in Nutraceutical Research. 2015;13(1):55-60.
BibTex	@article{ author = {Rad EY and Attar MJH and Koohdani F and Sabooryaraghi AA and Eshraghian MR and Javanbakht MH and Saboori S and Chamari M and And MZ and Djalali M}, title = {Effect of Vitamin D Supplementation on Thioredoxin Binding Protein 2 Gene Expression in Patients With Diabetes Type 2}, journal = {Current Topics in Nutraceutical Research}, volume = {13}, number = {1}, pages = {55-60}, year = {2015} }
RIS	TY - JOUR AU - Rad EY AU - Attar MJH AU - Koohdani F AU - Sabooryaraghi AA AU - Eshraghian MR AU - Javanbakht MH AU - Saboori S AU - Chamari M AU - And MZ AU - Djalali M TI - Effect of Vitamin D Supplementation on Thioredoxin Binding Protein 2 Gene Expression in Patients With Diabetes Type 2 JO - Current Topics in Nutraceutical Research VL - 13 IS - 1 SP - 55 EP - 60 PY - 2015 ER -

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