Comparison of Quinolone and Β-Lactam Resistance Among Escherichia Coli Strains Isolated From Urinary Tract Infections Pubmed



Tayebi Z¹ ; Heidari H² ; Kazemian H^{3, 4} ; Ghafoori SM¹ ; Boroumandi S^{1, 5} ; Houri H⁶ Show Affiliations
Source: Infezioni in Medicina Published:2016

Abstract

The growing frequency of antibiotic resistances is now a universal problem. Increasing resistance to new generations of β-lactam and quinolone antibiotics in multidrug- resistant Enterobacteriaceae isolates is considered an emergency health issue worldwide. The aim of this study was to evaluate plasmid-mediated quinolone resistance genes in ESBL-producing Escherichia coli isolated from urinary tract infections (UTIs). In our study ESBL- producing isolates were assessed by screening methods. After determination of antimicrobial susceptibility, detection of ESBLs and quinolone resistance genes was performed. A total of 97 ESBL-producing E. coli were determined. The blaTEM, blaSHV and blaCTX-M genes were detected in 90 isolates. The blaTEM was the most frequent- ly detected gene (46.4%), followed by blaSHV (31.9%) and blaCTX-M (14.4%). The most prevalent quinolone resistance gene among ESBL-producing isolates was oqxAB which found in 67 isolates (69.1%). The frequencies of the aac(6’)-Ib-cr, qnr and qepA were 65 (67%), 8 (8.2%) and 6 (6.2%), respectively. Our data indicate that the prevalence of plasmid-mediated quinolone resistance genes in ESBL-positive isolates is increasing. The co-dissemination of PMQR and ESBL genes among E. coli isolates can be considered a threat to public health. Therefore, prescription of antibiotics against infectious disease should be managed carefully. © 2016, International Society of Musculoskeletal and Neuronal Interactions. All rights reserved.