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Comparison of Quinolone and Β-Lactam Resistance Among Escherichia Coli Strains Isolated From Urinary Tract Infections Pubmed



Tayebi Z1 ; Heidari H2 ; Kazemian H3, 4 ; Ghafoori SM1 ; Boroumandi S1, 5 ; Houri H6
Authors
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Authors Affiliations
  1. 1. Microbiology Department, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran
  2. 2. Department of Bacteriology and Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  3. 3. Department of Medical Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Clinical Microbiology Research Center, Ilam University of Medical Sciences, Ilam, Iran
  5. 5. Pars Advance and Minimally Invasive Research Center, Pars hospital, Iran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Infezioni in Medicina Published:2016


Abstract

The growing frequency of antibiotic resistances is now a universal problem. Increasing resistance to new generations of β-lactam and quinolone antibiotics in multidrug- resistant Enterobacteriaceae isolates is considered an emergency health issue worldwide. The aim of this study was to evaluate plasmid-mediated quinolone resistance genes in ESBL-producing Escherichia coli isolated from urinary tract infections (UTIs). In our study ESBL- producing isolates were assessed by screening methods. After determination of antimicrobial susceptibility, detection of ESBLs and quinolone resistance genes was performed. A total of 97 ESBL-producing E. coli were determined. The blaTEM, blaSHV and blaCTX-M genes were detected in 90 isolates. The blaTEM was the most frequent- ly detected gene (46.4%), followed by blaSHV (31.9%) and blaCTX-M (14.4%). The most prevalent quinolone resistance gene among ESBL-producing isolates was oqxAB which found in 67 isolates (69.1%). The frequencies of the aac(6’)-Ib-cr, qnr and qepA were 65 (67%), 8 (8.2%) and 6 (6.2%), respectively. Our data indicate that the prevalence of plasmid-mediated quinolone resistance genes in ESBL-positive isolates is increasing. The co-dissemination of PMQR and ESBL genes among E. coli isolates can be considered a threat to public health. Therefore, prescription of antibiotics against infectious disease should be managed carefully. © 2016, International Society of Musculoskeletal and Neuronal Interactions. All rights reserved.
1. Molecular Mechanisms Associated With Quinolone Resistance in Enterobacteriaceae: Review and Update, Transactions of the Royal Society of Tropical Medicine and Hygiene (2020)
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