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Neural Stem/Progenitor Cell Transplantation for Spinal Cord Injury Treatment; a Systematic Review and Meta-Analysis Publisher Pubmed



Yousefifard M1 ; Rahimimovaghar V2 ; Nasirinezhad F3 ; Baikpour M4 ; Safari S5 ; Saadat S2 ; Moghadas Jafari A6 ; Asady H7 ; Razavi Tousi SMT1 ; Hosseini M2, 8, 9
Authors
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Authors Affiliations
  1. 1. Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Physiology Research Center, Department of Physiology, Iran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Emergency Medicine, Shohadaye Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Department of Emergency Medicine, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
  7. 7. Department of Occupational Health Engineering, Faculty of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  9. 9. Pediatric Chronic Kidney Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Neuroscience Published:2016


Abstract

Despite the vast improvements of cell therapy in spinal cord injury treatment, no optimum protocol has been developed for application of neural stem/progenitor cells. In this regard, the present meta-analysis showed that the efficacy of the neural stem/progenitor cell (NSPC) transplantation depends mainly on injury model, intervention phase, transplanted cell count, immunosuppressive use, and probably stem cell source. Improved functional recovery post NSPC transplantation was found to be higher in transection and contusion models. Moreover, NSPC transplantation in acute phase of spinal injury was found to have better functional recovery. Higher doses (>3 × 106 cell/kg) were also shown to be optimum for transplantation, but immunosuppressive agent administration negatively affected the motor function recovery. Scaffold use in NSPC transplantation could also effectively raise functional recovery. © 2016.
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