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Granulocyte-Colony Stimulating Factor May Improve Pregnancy Outcome in Patients With History of Unexplained Recurrent Implantation Failure: An Rct Publisher



Arefi S1, 2 ; Fazeli E3 ; Esfahani M1 ; Borhani N4 ; Yamini N5 ; Hosseini A1 ; Farifteh F1, 6
Authors
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Authors Affiliations
  1. 1. Genetics and In Vitro Assisted Reproductive (GIVAR) Center, Erfan Hospital, Tehran, Iran
  2. 2. Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran
  3. 3. Department of Anatomy and Reproductive Biology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran
  5. 5. IVF Center, Arash Hospital, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: International Journal of Reproductive BioMedicine Published:2018


Abstract

Background: Family of colony-stimulating factors (CSF) have an essential role on early cross talk between embryo and uterine endometrium. Objective: The aim of this study was to evaluate the effects of the single dose of Granulocyte-CSF (G-CSF) injection on clinical outcome of assisted reproductive technology cycle in patients with repeated implantation failures. Materials and Methods: This randomized control trial study was performed on 52 infertile women who referred to the clinic with the history of more than three previous In vitro fertilization/Intracytoplasmic sperm injection-embryo transfer failures. All patients were stimulated with standard long protocol. All embryos were transferred on day five in blastocyst stage in both groups. The treated group received 300 µg (0.5 ml) recombinant human G-CSF subcutaneously which was injected 30 min before blastocyst embryo transfer. Results: There was not statistically significant differences in abortion rate in G-CSF and control group (p=0.09). G-CSF treated group showed higher clinical pregnancy rate in comparison with control group (56.2% vs. 40.0%) but it was not statistically significant (p=0.09). Although live birth rate in G-CSF group was higher than control group (53.1% vs. 35.0%) but there wasn’t statistically significant difference in the overall live birth rate between the two groups (p=0.10). G-CSF group had a twin pregnancies while in control group there was no twin pregnancy. Conclusion: Our result demonstrates the possibility that pregnancy outcome is better in women with repeated unexplained In vitro fertilization failure who are treated with G-CSF. © 2018, Research and Clinical Center for Infertitlity. All rights reserved.
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1. Granulocyte Colony-Stimulating Factor in Repeated Ivf Failure, a Randomized Trial, Reproduction (2016)
2. The Role of G-Csf in Recurrent Implantation Failure: A Randomized Double Blind Placebo Control Trial, International Journal of Reproductive BioMedicine (2016)
3. Novel Immunotherapeutic Approaches for Treatment of Infertility, Biomedicine and Pharmacotherapy (2016)
4. A Comparison of Endometrial Thickness and Pregnancy Outcomes in Two Methods of Intrauterine Injection and Subcutaneous Injection of Gcsf in Infertile Women Candidates for Ivf, Journal of Obstetrics# Gynecology and Cancer Research (2020)
5. Efficacy of Intrauterine Infusion of Granulocyte Colony Stimulating Factor on Patients With History of Implantation Failure: A Randomized Control Trial, International Journal of Reproductive BioMedicine (2016)
6. Effect of Intrauterine Granulocyte-Colony Stimulating Factor Administration on in Vitro Fertilization Outcome in Women With Moderate-To-Severe Endometriosis: An Rct, International Journal of Reproductive BioMedicine (2021)
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