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Oxytocin Moderates Risky Decision-Making During the Iowa Gambling Task: A New Insight Based on the Role of Oxytocin Receptor Gene Polymorphisms and Interventional Cognitive Study Publisher Pubmed



Bozorgmehr A1, 2 ; Alizadeh F3 ; Sadeghi B4 ; Shahbazi A1 ; Norouzi Ofogh S1 ; Joghataei MT5 ; Razian S6 ; Heydari F7 ; Ghadirivasfi M8
Authors
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Authors Affiliations
  1. 1. Department of Neuroscience, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran
  2. 2. Student Research Committee, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran
  3. 3. Department of Genomic Psychiatry and Behavioral Genomics (DGPBG), Roozbeh Hospital, School of Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran
  4. 4. Department of Biochemistry, Institute of Biochemistry and Biophysics (IBB), University of Tehran, Tehran, Iran
  5. 5. Cellular and Molecular Research Center, Iran University of Medical Sciences (IUMS), Tehran, Iran
  6. 6. Department of Clinical Psychology, Faculty of Humanities, University of Science and Culture, Tehran, Iran
  7. 7. Faculty of Biological Sciences, Shahid Beheshti University, Tehran, Iran
  8. 8. Research Center for Addiction and Risky Behavior (ReCARB), Iran University of Medical Sciences (IUMS), Tehran, Iran

Source: Neuroscience Letters Published:2019


Abstract

The oxytocinergic system influences attentional bias towards emotional cues and feedback-based learning. Considering a tag single-nucleotide polymorphism (SNP) found through analysis of an intronic haplotype in the oxytocin receptor (OXTR) gene, we investigated the effect of oxytocin on risky decision-making via the Iowa Gambling Task (IGT). Young healthy males received intranasal oxytocin or placebo, and the IGT was performed where raw scores, net scores and total time were recorded, and ratio of advantageous to disadvantageous choices was calculated. Using PCR-pyrosequencing, a 761 bp target sequence in the OXTR gene was amplified and sequenced after the extraction of whole blood DNA. Employing Haploview, haplotypes and linkage disequilibrium (LD) pattern among all 14 SNPs in the intronic region were determined based on D′ and LOD values, and rs2254295 with the highest LD was indicated as the tag SNP. GTT was shown to have the highest frequency among the found haplotypes. Oxytocin group and participants with the TT genotype demonstrated a significantly increased raw score, net score and advantageous choices, whereas the total time was not influenced remarkably. This means that oxytocin significantly reduced the risk taking in decision-making, and participants with the TT genotype had less premature or risky decisions than those with the CT and CC genotypes. rs2254295 may modulate the function or expression of the OXTR gene, implying that T allele may increase the expression of the OXTR gene compared to C allele. We suggest that oxytocin may remarkably moderate the risk attitude and its consequences during uncertain decision-making. © 2019
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