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Genetic and Epigenetic Effects on Couple Adjustment in Context of Romantic Relationship: A Scoping Systematic Review Publisher



Khani P1 ; Ansari Dezfouli M2 ; Nasri F3, 4 ; Rahemi M5 ; Ahmadloo S6, 10 ; Afkhami H7 ; Saeidi F8 ; Tereshchenko S9 ; Bigdeli MR6, 10 ; Modarressi MH1
Authors
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Authors Affiliations
  1. 1. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran
  2. 2. Department of Neuroscience, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran
  3. 3. Immunology Research Center, Iran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  5. 5. Department of stem cell technology and tissue regeneration, Faculty of Science, Tehran University, Tehran, Iran
  6. 6. Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran
  7. 7. Department of Medical Microbiology, Faculty of Medicine, Shahed University of Medical Sciences, Tehran, Iran
  8. 8. Department of Medical Genetics, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran
  9. 9. Research Institute of Medical Problems of the North, Federal Research Center “Krasnoyarsk Science Center of the Siberian Branch of the Russian Academy of Sciences�, Krasnoyarsk, Russian Federation
  10. 10. Institute for Cognitive and Brain Sciences, Shahid Beheshti University, Tehran, Iran

Source: Frontiers in Genetics Published:2023


Abstract

Introduction: Couples’ relationships defined by a complex interaction between the two partners and their intrapersonal traits. Romantic; relationships and love are associated with marital satisfaction and stability, as well as couples’ happiness and health. Personality traits influence romantic relationships and, personality influenced by genetical and non-genetically factors. The roles of non-genetically factors such as socioeconomic position and external appearance have revealed in determining the quality of romantic relationships. Methods: We; performed a scoping systematic review to assess the association between genetics and epigenetic factors and romantic relationship. Relevant articles were identified by PubMed, EMBASE, Web of Science, Scopus, and the APA PsycInfo searching between inception and 4 June 2022. Results: Different studies evaluated the associated polymorphisms in 15 different genes or chromosomal regions. In the first step; we classified them into four groups: (1) Oxytocin-related signaling pathway (OXTR, CD38, and AVPR1A); (2) Serotonin-related signaling pathway (SLC6A4, HTR1A, and HTR2A); (3) Dopamine and catecholamine-related signaling pathway (DRD1, DRD2, DRD4, ANKK1, and COMT); and (4) other genes (HLA, GABRA2, OPRM1, and Y-DNA haplogroup D-M55). Then, we evaluated and extracted significant polymorphisms that affect couple adjustment and romantic relationships. Discussion: Overall, the findings suggest that genetic and epigenetics variants play a key role in marital adjustment and romantic relationships over time. Copyright © 2023 Khani, Ansari Dezfouli, Nasri, Rahemi, Ahmadloo, Afkhami, Saeidi, Tereshchenko, Bigdeli and Modarressi.
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