Synthesis, Admt Prediction, and in Vitro and in Silico Α-Glucosidase Inhibition Evaluations of New Quinoline-Quinazolinone-Thioacetamides

Synthesis, Admt Prediction, and in Vitro and in Silico Α-Glucosidase Inhibition Evaluations of New Quinoline-Quinazolinone-Thioacetamides Publisher

Safapoor S¹ ; Halimi M² ; Ghomi MK¹ ; Noori M³ ; Dastyafteh N³ ; Javanshir S³ ; Hosseini S⁴ ; Mojtabavi S⁵ ; Faramarzi MA⁵ ; Nasliesfahani E⁶ ; Larijani B¹ ; Fakhrioliaei A⁷ ; Dekamin MG³ ; Mohammadikhanaposhtani M⁸ Show All Authors

Safapoor S¹
Halimi M²
Ghomi MK¹
Noori M³
Dastyafteh N³
Javanshir S³
Hosseini S⁴
Mojtabavi S⁵
Faramarzi MA⁵
Nasliesfahani E⁶
Larijani B¹
Fakhrioliaei A⁷
Dekamin MG³
Mohammadikhanaposhtani M⁸
Mahdavi M¹

Show Affiliations

1. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Biology, Islamic Azad University, Babol Branch, Babol, Iran
3. Pharmaceutical and Heterocyclic Chemistry Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran
4. Shahid Beheshti University of Medical Sciences, Tehran, Iran
5. Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
6. Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
7. Faculty of Pharmacy, Islamic Azad University, Pharmaceutical Sciences Branch, Tehran, Iran
8. Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran

Source: RSC Advances Published:2023

Abstract

In this work, a new series of quinoline-quinazolinone-thioacetamide derivatives 9a-p were designed using a combination of effective pharmacophores of the potent α-glucosidase inhibitors. These compounds were synthesized by simple chemical reactions and evaluated for their anti-α-glucosidase activity. Among the tested compounds, compounds 9a, 9f, 9g, 9j, 9k, and 9m demonstrated significant inhibition effects in comparison to the positive control acarbose. Particularly, compound 9g with inhibitory activity around 83-fold more than acarbose exhibited the best anti-α-glucosidase activity. Compound 9g showed a competitive type of inhibition in the kinetic study, and the molecular simulation studies demonstrated that this compound with a favorable binding energy occupied the active site of α-glucosidase. Furthermore, in silico ADMET studies of the most potent compounds 9g, 9a, and 9f were performed to predict their drug-likeness, pharmacokinetic, and toxicity properties. © 2023 The Royal Society of Chemistry.

Style	Citing Format
MLA	Safapoor S, et al.. "Synthesis, Admt Prediction, and in Vitro and in Silico Α-Glucosidase Inhibition Evaluations of New Quinoline-Quinazolinone-Thioacetamides." RSC Advances, vol. 13, no. 28, 2023, pp. 19243-19256.
APA	Safapoor S, Halimi M, Ghomi MK, Noori M, Dastyafteh N, Javanshir S, Hosseini S, Mojtabavi S, Faramarzi MA, Nasliesfahani E, Larijani B, Fakhrioliaei A, Dekamin MG, Mohammadikhanaposhtani M, Mahdavi M (2023). Synthesis, Admt Prediction, and in Vitro and in Silico Α-Glucosidase Inhibition Evaluations of New Quinoline-Quinazolinone-Thioacetamides. RSC Advances, 13(28), 19243-19256.
Chicago	Safapoor S, Halimi M, Ghomi MK, Noori M, Dastyafteh N, Javanshir S, Hosseini S, et al.. "Synthesis, Admt Prediction, and in Vitro and in Silico Α-Glucosidase Inhibition Evaluations of New Quinoline-Quinazolinone-Thioacetamides." RSC Advances 13, no. 28 (2023): 19243-19256.
Harvard	Safapoor S et al. (2023) 'Synthesis, Admt Prediction, and in Vitro and in Silico Α-Glucosidase Inhibition Evaluations of New Quinoline-Quinazolinone-Thioacetamides', RSC Advances, 13(28), pp. 19243-19256.
Vancouver	Safapoor S, Halimi M, Ghomi MK, Noori M, Dastyafteh N, Javanshir S, et al.. Synthesis, Admt Prediction, and in Vitro and in Silico Α-Glucosidase Inhibition Evaluations of New Quinoline-Quinazolinone-Thioacetamides. RSC Advances. 2023;13(28):19243-19256.
BibTex	@article{ author = {Safapoor S and Halimi M and Ghomi MK and Noori M and Dastyafteh N and Javanshir S and Hosseini S and Mojtabavi S and Faramarzi MA and Nasliesfahani E and Larijani B and Fakhrioliaei A and Dekamin MG and Mohammadikhanaposhtani M and Mahdavi M}, title = {Synthesis, Admt Prediction, and in Vitro and in Silico Α-Glucosidase Inhibition Evaluations of New Quinoline-Quinazolinone-Thioacetamides}, journal = {RSC Advances}, volume = {13}, number = {28}, pages = {19243-19256}, year = {2023} }
RIS	TY - JOUR AU - Safapoor S AU - Halimi M AU - Ghomi MK AU - Noori M AU - Dastyafteh N AU - Javanshir S AU - Hosseini S AU - Mojtabavi S AU - Faramarzi MA AU - Nasliesfahani E AU - Larijani B AU - Fakhrioliaei A AU - Dekamin MG AU - Mohammadikhanaposhtani M AU - Mahdavi M TI - Synthesis, Admt Prediction, and in Vitro and in Silico Α-Glucosidase Inhibition Evaluations of New Quinoline-Quinazolinone-Thioacetamides JO - RSC Advances VL - 13 IS - 28 SP - 19243 EP - 19256 PY - 2023 ER -

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