Benzoylquinazolinone Derivatives As New Potential Antidiabetic Agents: Α-Glucosidase Inhibition, Kinetic, and Docking Studies

Benzoylquinazolinone Derivatives As New Potential Antidiabetic Agents: Α-Glucosidase Inhibition, Kinetic, and Docking Studies Publisher

Mohammadikhanaposhtani M¹ ; Yahyavi H² ; Imanparast S³ ; Harandi FN⁴ ; Faramarzi MA³ ; Foroumadi A² ; Larijani B⁵ ; Biglar M⁵ ; Mahdavi M⁵

Show Affiliations

1. Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
2. Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
3. Department of Pharmaceutical Biotechnology, Faculty of Pharmacy and Biotechnology Research Center, Tehran University of Medical Sciences, Tehran, Iran
4. Biotechnology Group, Chemical Engineering Department, Tarbiat Modares University, Tehran, Iran
5. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of the Chinese Chemical Society Published:2020

Abstract

Benzoylquinazolinone derivatives 3a–n were synthesized via a simple one-step reaction, and evaluated for in vitro α-glucosidase inhibitory activity. Compounds 3d, 3f–g, 3i, and 3m–n showed more inhibitory activity than standard drug acarbose (IC50 = 750.0 ± 1.5 μM), and among them, compound 3d displayed the highest α-glucosidase inhibitory activity (IC50 = 261.6 ± 0.1 μM). The kinetic analysis of the compound 3d revealed that this compound inhibited α-glucosidase in a competitive manner (Ki = 255 μM). The docking studies were applied to predict binding modes of the synthesized compounds in active site of α-glucosidase. © 2019 The Chemical Society Located in Taipei & Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

Style	Citing Format
MLA	Mohammadikhanaposhtani M, et al.. "Benzoylquinazolinone Derivatives As New Potential Antidiabetic Agents: Α-Glucosidase Inhibition, Kinetic, and Docking Studies." Journal of the Chinese Chemical Society, vol. 67, no. 5, 2020, pp. 856-863.
APA	Mohammadikhanaposhtani M, Yahyavi H, Imanparast S, Harandi FN, Faramarzi MA, Foroumadi A, Larijani B, Biglar M, Mahdavi M (2020). Benzoylquinazolinone Derivatives As New Potential Antidiabetic Agents: Α-Glucosidase Inhibition, Kinetic, and Docking Studies. Journal of the Chinese Chemical Society, 67(5), 856-863.
Chicago	Mohammadikhanaposhtani M, Yahyavi H, Imanparast S, Harandi FN, Faramarzi MA, Foroumadi A, Larijani B, Biglar M, Mahdavi M. "Benzoylquinazolinone Derivatives As New Potential Antidiabetic Agents: Α-Glucosidase Inhibition, Kinetic, and Docking Studies." Journal of the Chinese Chemical Society 67, no. 5 (2020): 856-863.
Harvard	Mohammadikhanaposhtani M et al. (2020) 'Benzoylquinazolinone Derivatives As New Potential Antidiabetic Agents: Α-Glucosidase Inhibition, Kinetic, and Docking Studies', Journal of the Chinese Chemical Society, 67(5), pp. 856-863.
Vancouver	Mohammadikhanaposhtani M, Yahyavi H, Imanparast S, Harandi FN, Faramarzi MA, Foroumadi A, et al.. Benzoylquinazolinone Derivatives As New Potential Antidiabetic Agents: Α-Glucosidase Inhibition, Kinetic, and Docking Studies. Journal of the Chinese Chemical Society. 2020;67(5):856-863.
BibTex	@article{ author = {Mohammadikhanaposhtani M and Yahyavi H and Imanparast S and Harandi FN and Faramarzi MA and Foroumadi A and Larijani B and Biglar M and Mahdavi M}, title = {Benzoylquinazolinone Derivatives As New Potential Antidiabetic Agents: Α-Glucosidase Inhibition, Kinetic, and Docking Studies}, journal = {Journal of the Chinese Chemical Society}, volume = {67}, number = {5}, pages = {856-863}, year = {2020} }
RIS	TY - JOUR AU - Mohammadikhanaposhtani M AU - Yahyavi H AU - Imanparast S AU - Harandi FN AU - Faramarzi MA AU - Foroumadi A AU - Larijani B AU - Biglar M AU - Mahdavi M TI - Benzoylquinazolinone Derivatives As New Potential Antidiabetic Agents: Α-Glucosidase Inhibition, Kinetic, and Docking Studies JO - Journal of the Chinese Chemical Society VL - 67 IS - 5 SP - 856 EP - 863 PY - 2020 ER -

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