Natural Products As Promising Targets in Glioblastoma Multiforme: A Focus on Nf-Κb Signaling Pathway Publisher Pubmed



Soukhtanloo M¹ ; Mohtashami E² ; Maghrouni A³ ; Mollazadeh H⁴ ; Mousavi SH⁵ ; Roshan MK¹ ; Tabatabaeizadeh SA⁶ ; Hosseini A² ; Vahedi MM⁷ ; Jalilinik M¹ ; Afshari AR⁴
Source: Pharmacological Reports Published:2020

Abstract

Background: Glioblastoma multiforme (GBM), as the broadest cerebrum tumor, is resistant to current medical interventions, particularly chemo/radiation. Hence, it necessitates further therapeutic options that could enhance the efficacy of existing modalities. Methods: A comprehensive and systematic review of literature on the NF-κB signaling pathway-contributed in the pathogenesis of GBM with a focus on natural products was carried out. Results: Several examinations have shown that nuclear factor (NF)-κB is participated in apoptosis, cellular proliferation, angiogenesis, metastasis, invasion, and many other processes implicated in GBM pathobiology. Recent studies have provided that NF-κB regulation is the primary pharmacological target for GBM therapy. Specific natural products are involved in several signaling pathways implicated in tumor growth and apoptosis of GBM cells. Conclusion: In the current review, we elaborate on the role of NF-κB as a promising target in GBM and discuss some natural products affecting the NF-κB signaling pathway. © 2020, Maj Institute of Pharmacology Polish Academy of Sciences.