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Natural Products As Promising Targets in Glioblastoma Multiforme: A Focus on Nf-Κb Signaling Pathway Publisher Pubmed



Soukhtanloo M1 ; Mohtashami E2 ; Maghrouni A3 ; Mollazadeh H4 ; Mousavi SH5 ; Roshan MK1 ; Tabatabaeizadeh SA6 ; Hosseini A2 ; Vahedi MM7 ; Jalilinik M1 ; Afshari AR4
Authors
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Authors Affiliations
  1. 1. Department of Medical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  2. 2. Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran
  3. 3. Department of Medical Genetics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Physiology and Pharmacology, Faculty of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran
  5. 5. Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  6. 6. Social Development and Health Promotion Research Center, Gonabad University of Medical Sciences, Gonabad, Iran
  7. 7. Department of Pharmacology, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran

Source: Pharmacological Reports Published:2020


Abstract

Background: Glioblastoma multiforme (GBM), as the broadest cerebrum tumor, is resistant to current medical interventions, particularly chemo/radiation. Hence, it necessitates further therapeutic options that could enhance the efficacy of existing modalities. Methods: A comprehensive and systematic review of literature on the NF-κB signaling pathway-contributed in the pathogenesis of GBM with a focus on natural products was carried out. Results: Several examinations have shown that nuclear factor (NF)-κB is participated in apoptosis, cellular proliferation, angiogenesis, metastasis, invasion, and many other processes implicated in GBM pathobiology. Recent studies have provided that NF-κB regulation is the primary pharmacological target for GBM therapy. Specific natural products are involved in several signaling pathways implicated in tumor growth and apoptosis of GBM cells. Conclusion: In the current review, we elaborate on the role of NF-κB as a promising target in GBM and discuss some natural products affecting the NF-κB signaling pathway. © 2020, Maj Institute of Pharmacology Polish Academy of Sciences.
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