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Recent Advances in Glioblastoma Multiforme Therapy: A Focus on Autophagy Regulation Publisher Pubmed



Sanati M1, 2 ; Binabaj MM3 ; Ahmadi SS4 ; Aminyavari S5 ; Javid H6 ; Mollazadeh H4 ; Bibak B7 ; Mohtashami E7 ; Jamialahmadi T8, 9 ; Afshari AR4, 7 ; Sahebkar A8, 10, 11
Authors

Source: Biomedicine and Pharmacotherapy Published:2022


Abstract

Despite conventional treatment options including chemoradiation, patients with the most aggressive primary brain tumor, glioblastoma multiforme (GBM), experience an average survival time of less than 15 months. Regarding the malignant nature of GBM, extensive research and discovery of novel treatments are urgently required to improve the patients’ prognosis. Autophagy, a crucial physiological pathway for the degradation and recycling of cell components, is one of the exciting targets of GBM studies. Interventions aimed at autophagy activation or inhibition have been explored as potential GBM therapeutics. This review, which delves into therapeutic techniques to block or activate autophagy in preclinical and clinical research, aims to expand our understanding of available therapies battling GBM. © 2022 The Authors
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