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Pharmacotherapeutic Potential of Walnut (Juglans Spp.) in Age-Related Neurological Disorders Publisher



Hosseini Adarmanabadi SMH1 ; Karami Gilavand H1 ; Taherkhani A1 ; Sadat Rafiei SK1 ; Shahrokhi M2 ; Faaliat S3 ; Biabani M3 ; Abil E4 ; Ansari A5 ; Sheikh Z6 ; Poudineh M7 ; Khalaji A8 ; Shojaeibaghini M9 ; Koorangi A1 Show All Authors
Authors
  1. Hosseini Adarmanabadi SMH1
  2. Karami Gilavand H1
  3. Taherkhani A1
  4. Sadat Rafiei SK1
  5. Shahrokhi M2
  6. Faaliat S3
  7. Biabani M3
  8. Abil E4
  9. Ansari A5
  10. Sheikh Z6
  11. Poudineh M7
  12. Khalaji A8
  13. Shojaeibaghini M9
  14. Koorangi A1
  15. Deravi N1
Show Affiliations
Authors Affiliations
  1. 1. Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  3. 3. Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
  4. 4. Chemical Engineering Department, Faculty of Engineering, Ferdowsi University of Mashhad (FUM), Mashhad, Iran
  5. 5. Laboratory Science, Hormozgan University of Medical Science, Bandar Abbas, Iran
  6. 6. Student Research Committee, School of medicine, Babol University of Medical Sciences, Babol, Iran
  7. 7. School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
  8. 8. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  9. 9. Medical Informatics, Research Center, Institute for Futures Studies in Health, Kerman, Iran

Source: IBRO Neuroscience Reports Published:2023


Abstract

Global and regional trends of population aging spotlight major public health concerns. As one of the most common adverse prognostic factors, advanced age is associated with a remarkable incidence risk of many non-communicable diseases, affecting major organ systems of the human body. Age-dependent factors and molecular processes can change the nervous system's normal function and lead to neurodegenerative disorders. Oxidative stress results from of a shift toward reactive oxygen species (ROS) production in the equilibrium between ROS generation and the antioxidant defense system. Oxidative stress and neuroinflammation caused by Amyloid-ß protein deposition in the human brain are the most likely pathogenesis of Alzheimer's disease (AD). Walnut extracts could reduce Amyloid-ß fibrillation and aggregation, indicating their beneficial effects on memory and cognition. Walnut can also improve movement disabilities in Parkinson's disease due to their antioxidant and neuroprotective effect by reducing ROS and nitric oxide (NO) generation and suppressing oxidative stress. It is noteworthy that Walnut compounds have potential antiproliferative effects on Glioblastoma (the most aggressive primary cerebral neoplasm). This effective therapeutic agent can stimulate apoptosis of glioma cells in response to oxidative stress, concurrent with preventing angiogenesis and migration of tumor cells, improving the quality of life and life expectancy of patients with glioblastoma. Antioxidant Phenolic compounds of the Walnut kernel could explain the significant anti-convulsion ability of Walnut to provide good prevention and treatment for epileptic seizures. Moreover, the anti-inflammatory effect of Walnut oil could be beneficial in treating multiple sclerosis. In this study, we review the pharmaceutical properties of Walnut in age-related neurological disorders. © 2022 The Authors
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