Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Introduction to the Neuroimmunology of Multiple Sclerosis Publisher



Yazdanpanah N1, 2, 3 ; Rezaei N2, 3, 4
Authors
Show Affiliations
Authors Affiliations
  1. 1. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  4. 4. Department of Immunology, School of Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran

Source: Translational Neuroimmunology: Multiple Sclerosis: Volume 8 Published:2023


Abstract

Multiple sclerosis (MS), known as the most common demyelinating disease in high-income regions, is a chronic disabling disease with an autoimmune pathology, mainly affecting the central nervous system (CNS). In 1868, for the first time, Jean-Martin Charcot described the features of MS as la sclerose en plaques. MS physiopathology is a complex picture of interactions between various environmental and genetic factors. Therefore, it is necessary to reap the benefits of interdisciplinary approaches both in basic science studies and in the clinic. Translational research is of utmost importance in complex diseases like MS to help apply preclinical and laboratory findings in clinical practice. © 2023 Elsevier Inc. All rights reserved.
Related Docs
View other Related Docs
1. Autoimmune Diseases, Clinical Immunology (2022)
2. Monoclonal Antibodies in Multiple Sclerosis Treatment, Translational Neuroimmunology: Multiple Sclerosis: Volume 8 (2023)
3. Interleukin 7 Receptor Polymorphisms and the Risk of Multiple Sclerosis: A Meta-Analysis, Multiple Sclerosis and Related Disorders (2016)
4. B Cells in Multiple Sclerosis Therapy—A Comprehensive Review, Acta Neurologica Scandinavica (2018)
5. Consensus Recommendations for the Diagnosis and Treatment of Multiple Sclerosis: 2019 Revisions to the Menactrims Guidelines, Multiple Sclerosis and Related Disorders (2020)
6. Multiple Sclerosis Pathogenesis: Missing Pieces of an Old Puzzle, Reviews in the Neurosciences (2019)
7. Consensus Recommendations for Diagnosis and Treatment of Multiple Sclerosis: 2023 Revision of the Menactrims Guidelines, Multiple Sclerosis and Related Disorders (2024)
8. Association Between Interleukin 2 Receptor a Gene Polymorphisms (Rs2104286 and Rs12722489) With Susceptibility to Multiple Sclerosis in Iranian Population, Meta Gene (2020)
Experts (# of related papers)
View all Related Experts
Mohammad Ali Sahraian (15)
Nima Rezaei (3)
Other Related Docs
9. Intervening to Reduce the Risk of Future Disability From Multiple Sclerosis: Are We There Yet?, International Journal of Neuroscience (2017)
10. The Role of the Cerebellum in Multiple Sclerosis, Cerebellum (2015)
11. Consensus Recommendations for the Diagnosis and Treatment of Multiple Sclerosis: The Middle East North Africa Committee for Treatment and Research in Multiple Sclerosis (Menactrims), Current Medical Research and Opinion (2015)
12. Current and Future Trends in Multiple Sclerosis Management: Near East Perspective, Multiple Sclerosis and Related Disorders (2023)
13. Association of Cd58 Polymorphism With Multiple Sclerosis and Response to Interferon ß Therapy in a Subset of Iranian Population, Cell Journal (2015)
14. Association Between Il7 Receptor Alpha (Il7ra) Gene Rs6897932 Polymorphism and the Risk of Multiple Sclerosis: A Meta-Regression and Meta-Analysis., Multiple Sclerosis and Related Disorders (2021)
15. Efficacy of Disease Modifying Therapies in Progressive Ms and How Immune Senescence May Explain Their Failure, Frontiers in Neurology (2022)
16. Immune-Mediated Cognition Impairment in Multiple Sclerosis, Translational Neuroimmunology: Multiple Sclerosis: Volume 8 (2023)
17. Role of B Cells in the Pathogenesis of Multiple Sclerosis: Mechanisms of Action, Multiple Sclerosis: A Mechanistic View (2016)
18. The Role of Nutritional Factors During Adolescence in Multiple Sclerosis Onset: A Population-Based Incident Case–Control Study, Nutritional Neuroscience (2021)
19. Widespread Disruptions of White Matter in Familial Multiple Sclerosis: Dti and Noddi Study, Frontiers in Neurology (2021)
20. Immunomodulatory Function of Treg-Derived Exosomes Is Impaired in Patients With Relapsing-Remitting Multiple Sclerosis, Immunologic Research (2018)
21. Worldwide Prevalence of Familial Multiple Sclerosis: A Systematic Review and Meta-Analysis, Multiple Sclerosis and Related Disorders (2018)
22. Primary Progressive Multiple Sclerosis in Iran: A Consensus Recommendation for Diagnosis and Management, Multiple Sclerosis and Related Disorders (2018)
23. Clinical Characteristics and Disability Progression of Early-And Late-Onset Multiple Sclerosis Compared to Adult-Onset Multiple Sclerosis, Journal of Clinical Medicine (2020)
24. Early Predictors of Conversion to Secondary Progressive Multiple Sclerosis, Multiple Sclerosis and Related Disorders (2021)
25. Multiple Sclerosis Epidemiology in Middle East and North Africa: A Systematic Review and Meta-Analysis, Neuroepidemiology (2015)
26. Current Advances in Stem Cell Therapy in the Treatment of Multiple Sclerosis, Reviews in the Neurosciences (2023)
27. Evaluating the Efficacy and Safety of Zytuxtm (Rituximab, Aryogen Pharmed) in Iranian Multiple Sclerosis Patients: An Observational Study, Multiple Sclerosis and Related Disorders (2019)
28. Immunopathogenesis of Multiple Sclerosis: Molecular and Cellular Mechanisms and New Immunotherapeutic Approaches, Immunopharmacology and Immunotoxicology (2024)
29. Monogenic Polyautoimmunity in Primary Immunodeficiency Diseases, Autoimmunity Reviews (2018)
30. Association Between Disease-Modifying Therapies and Adverse Clinical Outcomes in Multiple Sclerosis Patients With Covid-19 Infection, Multiple Sclerosis and Related Disorders (2022)
31. Immune Reconstitution Therapy or Continuous Immunosuppression for the Management of Active Relapsing–Remitting Multiple Sclerosis Patients? a Narrative Review, Neurology and Therapy (2020)
32. Association of Two Polymorphisms in Msh2 and Xrcc1 Genes With Multiple Sclerosis in Iranian Population, Physiology and Pharmacology (2016)
33. Association of Hla-Dra and Il2ra Polymorphisms With the Severity and Relapses Rate of Multiple Sclerosis in an Iranian Population, Reports of Biochemistry and Molecular Biology (2020)
34. Ebv Infection and Vitamin D in Multiple Sclerosis Patients, Nutrition and Lifestyle in Neurological Autoimmune Diseases: Multiple Sclerosis (2017)
35. Integrated Cognitive Rehabilitation Home-Based Protocol to Improve Cognitive Functions in Multiple Sclerosis Patients: A Randomized Controlled Study, Journal of Clinical Medicine (2022)
36. Pharmacogenetics: A Strategy for Personalized Medicine for Autoimmune Diseases, Clinical Genetics (2018)
37. Plp1 Mutations in Patients With Multiple Sclerosis: Identification of a New Mutation and Potential Pathogenicity of the Mutations, Journal of Clinical Medicine (2018)
38. Effectiveness of Repetitive Transcranial Magnetic Stimulation (Rtms) Add-On Therapy to a Standard Treatment in Individuals With Multiple Sclerosis and Concomitant Symptoms of Depression—Results From a Randomized Clinical Trial and Pilot Study, Journal of Clinical Medicine (2023)
39. Lnc-Hnf1a-As1 and Its Target Gene Atg5 Is Dysregulated in Hla-Drb1*15:01-Negative Female Patients With Multiple Sclerosis, Gene Reports (2022)
40. Dysregulation of Micrornas Regulating Survivin in Cd4+ T Cells in Multiple Sclerosis, Multiple Sclerosis and Related Disorders (2020)
41. Il-7Ra Association and Genotype-Dependent Severity and Response to Ifn-Β Therapy in Multiple Sclerosis, Acta Medica Iranica (2019)
42. Pharmacotherapeutic Potential of Walnut (Juglans Spp.) in Age-Related Neurological Disorders, IBRO Neuroscience Reports (2023)
43. The Barriers and Facilitators to Health-Promoting Lifestyle Behaviors Among People With Multiple Sclerosis During the Coronavirus Disease 2019 Pandemic: A Content Analysis Study, BMC Neurology (2022)