Metabolomics Prospect of Obesity and Metabolic Syndrome; a Systematic Review

Metabolomics Prospect of Obesity and Metabolic Syndrome; a Systematic Review Publisher

Payab M¹ ; Tayanloobeik A² ; Falahzadeh K³ ; Mousavi M² ; Salehi S² ; Djalalinia S⁴ ; Ebrahimpur M⁵ ; Rezaei N^{6, 7} ; Rezaeitavirani M⁸ ; Larijani B⁹ ; Arjmand B² ; Gilany K^{10, 11}

Show Affiliations

1. Metabolomics and Genomics Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
2. Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
3. Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
4. Development of Research & Technology Center, Deputy of Research and Technology, Ministry of Health and Medical Education, Tehran, Iran
5. Elderly Health Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
6. Medical Library and Information Science, Department of Medical Library and Information Science, Paramedicine Faculty, Tehran University of Medical Sciences, Tehran, Iran
7. Department of Medical Library and Information Science, Paramedicine Faculty, Hamadan University of Medical Sciences, Hamadan, Iran
8. Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
9. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
10. Reproductive Immunology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran
11. Integrative Oncology Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran

Source: Journal of Diabetes and Metabolic Disorders Published:2022

Abstract

Purpose: Due to growing concerns about the obesity pandemic as a worldwide phenomenon, a global effort has been made for managing it and associated disorders. Accordingly, metabolomics as a promising field of “OMICS” is presented for investigating different molecular pathways in obesity and related disorders through the evaluation of specific metabolites in both animal and human subjects. Herein, the aim of the present study as the first systematic review is to evaluate all available studies about different mechanisms and their biomarkers discovery using metabolomics approaches. Method: The study was designed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Using a comprehensive search strategy we searched in databases including; Web of Science, PubMed, and Scopus using specific keywords. Based on predefined inclusion/exclusion criteria study selection has been conducted considering the type of studies, participant, and outcome measures. Quality assessment was done using CASP (Critical Appraisal Skills Programme) checklist followed by data extraction according to a predefined data extraction sheet. Results: Among the articles that resulted from electronic search, a total of 74 articles met our inclusion criteria. The most prevalent studied metabolites were amino acids and lipid derivatives and both targeted and non-targeted approaches were applied for metabolomics studies. Conclusion: This systematic review summarized a wide range of studies regardless of the age, history, language, and type of the study. Further studies are needed to compare the application of emerging methods in the treatment of obesity and related disorders. © 2021, Springer Nature Switzerland AG.

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Style	Citing Format
MLA	Payab M, et al.. "Metabolomics Prospect of Obesity and Metabolic Syndrome; a Systematic Review." Journal of Diabetes and Metabolic Disorders, vol. 21, no. 1, 2022, pp. 889-917.
APA	Payab M, Tayanloobeik A, Falahzadeh K, Mousavi M, Salehi S, Djalalinia S, Ebrahimpur M, Rezaei N, Rezaeitavirani M, Larijani B, Arjmand B, Gilany K (2022). Metabolomics Prospect of Obesity and Metabolic Syndrome; a Systematic Review. Journal of Diabetes and Metabolic Disorders, 21(1), 889-917.
Chicago	Payab M, Tayanloobeik A, Falahzadeh K, Mousavi M, Salehi S, Djalalinia S, Ebrahimpur M, et al.. "Metabolomics Prospect of Obesity and Metabolic Syndrome; a Systematic Review." Journal of Diabetes and Metabolic Disorders 21, no. 1 (2022): 889-917.
Harvard	Payab M et al. (2022) 'Metabolomics Prospect of Obesity and Metabolic Syndrome; a Systematic Review', Journal of Diabetes and Metabolic Disorders, 21(1), pp. 889-917.
Vancouver	Payab M, Tayanloobeik A, Falahzadeh K, Mousavi M, Salehi S, Djalalinia S, et al.. Metabolomics Prospect of Obesity and Metabolic Syndrome; a Systematic Review. Journal of Diabetes and Metabolic Disorders. 2022;21(1):889-917.
BibTex	@article{ author = {Payab M and Tayanloobeik A and Falahzadeh K and Mousavi M and Salehi S and Djalalinia S and Ebrahimpur M and Rezaei N and Rezaeitavirani M and Larijani B and Arjmand B and Gilany K}, title = {Metabolomics Prospect of Obesity and Metabolic Syndrome; a Systematic Review}, journal = {Journal of Diabetes and Metabolic Disorders}, volume = {21}, number = {1}, pages = {889-917}, year = {2022} }
RIS	TY - JOUR AU - Payab M AU - Tayanloobeik A AU - Falahzadeh K AU - Mousavi M AU - Salehi S AU - Djalalinia S AU - Ebrahimpur M AU - Rezaei N AU - Rezaeitavirani M AU - Larijani B AU - Arjmand B AU - Gilany K TI - Metabolomics Prospect of Obesity and Metabolic Syndrome; a Systematic Review JO - Journal of Diabetes and Metabolic Disorders VL - 21 IS - 1 SP - 889 EP - 917 PY - 2022 ER -

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