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A Review of the Interaction Between Mirnas and Ebola Virus Publisher



E Kakavandi EHSAN ; J Yavarian JILA ; M Farzanehpour MAHDIEH ; M Shayestehpour MOHAMMAD
Authors

Source: International Journal of Molecular and Cellular Medicine Published:2024


Abstract

Ebola virus (EBOV) is a life-threatening and virulent pathogen that kills approximately 90 percent of infected individuals. Nowadays, microRNAs (miRNAs) have become a promising option for more efficient screening, diagnosis, monitoring, and therapy of numerous diseases such as cancer, stroke, Alzheimer’s, and viral infections. Recent studies have revealed the role of EBOV and host-encoded miRNAs in Ebola virus disease (EVD), opening an avenue for developing novel drugs against EVD and diagnostic panels for EBOV infection. EBOV-encoded miRNAs such as miR-VP-3p and miR-1-5p and anti-EBOV host cell miRNAs such as has-miR-150-3p, has-miR-103b and has-miR-145-3p might be a possible diagnostic biomarker or druggable targets. This paper highlights the importance of viral and cellular miRNAs in EBOV infection and EVD. © 2024 Elsevier B.V., All rights reserved.
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