The Emerging Role of Micrornas in the Severe Acute Respiratory Syndrome Coronavirus 2 (Sars-Cov-2) Infection

The Emerging Role of Micrornas in the Severe Acute Respiratory Syndrome Coronavirus 2 (Sars-Cov-2) Infection Publisher Pubmed

Mirzaei R^{1, 2} ; Mahdavi F³ ; Badrzadeh F⁴ ; Hosseinifard SR⁵ ; Heidary M⁶ ; Jeda AS⁷ ; Mohammadi T⁸ ; Roshani M¹ ; Yousefimashouf R^{1, 9} ; Keyvani H^{7, 10} ; Darvishmotevalli M¹¹ ; Sani MZ¹² ; Karampoor S^{7, 10}

Show Affiliations

1. Department of Microbiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
2. Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran
3. Department of Medical Parasitology and Mycology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
4. Faculty of Medicine, Golestan University of Medical Sciences, Golestan, Iran
5. Department of Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
6. Department of Environmental Health Engineering, Yasuj University of Medical Sciences, Yasuj, Iran
7. Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
8. Department of Biostatistics, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran
9. Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
10. Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran
11. Research Center For Health, Safety And Environment (RCHSE), Alborz University of Medical Sciences, Karaj, Iran
12. Pediatric Specialist, Mashhad, Iran

Source: International Immunopharmacology Published:2021

Abstract

The novel coronavirus disease 2019 (COVID-19) pandemic has imposed significant public health problems for the human populations worldwide after the 1918 influenza A virus (IVA) (H1N1) pandemic. Although numerous efforts have been made to unravel the mechanisms underlying the coronavirus, a notable gap remains in our perception of the COVID-19 pathogenesis. The innate and adaptive immune systems have a pivotal role in the fate of viral infections, such as COVID-19 pandemic. MicroRNAs (miRNAs) are known as short noncoding RNA molecules and appear as indispensable governors of almost any cellular means. Several lines of evidence demonstrate that miRNAs participate in essential mechanisms of cell biology, regulation of the immune system, and the onset and progression of numerous types of disorders. The immune responses to viral respiratory infections (VRIs), including influenza virus (IV), respiratory syncytial virus (RSV), and rhinovirus (RV), are correlated with the ectopic expression of miRNAs. Alterations of the miRNA expression in epithelial cells may contribute to the pathogenesis of chronic and acute airway infections. Hence, analyzing the role of these types of nucleotides in antiviral immune responses and the characterization of miRNA target genes might contribute to understanding the mechanisms of the interplay between the host and viruses, and in the future, potentially result in discovering therapeutic strategies for the prevention and treatment of acute COVID-19 infection. In this article, we present a general review of current studies concerning the function of miRNAs in different VRIs, particularly in coronavirus infection, and address all available therapeutic prospects to mitigate the burden of viral infections. © 2020

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Style	Citing Format
MLA	Mirzaei R, et al.. "The Emerging Role of Micrornas in the Severe Acute Respiratory Syndrome Coronavirus 2 (Sars-Cov-2) Infection." International Immunopharmacology, vol. 90, no. , 2021, pp. -.
APA	Mirzaei R, Mahdavi F, Badrzadeh F, Hosseinifard SR, Heidary M, Jeda AS, Mohammadi T, Roshani M, Yousefimashouf R, Keyvani H, Darvishmotevalli M, Sani MZ, Karampoor S (2021). The Emerging Role of Micrornas in the Severe Acute Respiratory Syndrome Coronavirus 2 (Sars-Cov-2) Infection. International Immunopharmacology, 90(), -.
Chicago	Mirzaei R, Mahdavi F, Badrzadeh F, Hosseinifard SR, Heidary M, Jeda AS, Mohammadi T, et al.. "The Emerging Role of Micrornas in the Severe Acute Respiratory Syndrome Coronavirus 2 (Sars-Cov-2) Infection." International Immunopharmacology 90, no. (2021): -.
Harvard	Mirzaei R et al. (2021) 'The Emerging Role of Micrornas in the Severe Acute Respiratory Syndrome Coronavirus 2 (Sars-Cov-2) Infection', International Immunopharmacology, 90(), pp. -.
Vancouver	Mirzaei R, Mahdavi F, Badrzadeh F, Hosseinifard SR, Heidary M, Jeda AS, et al.. The Emerging Role of Micrornas in the Severe Acute Respiratory Syndrome Coronavirus 2 (Sars-Cov-2) Infection. International Immunopharmacology. 2021;90():-.
BibTex	@article{ author = {Mirzaei R and Mahdavi F and Badrzadeh F and Hosseinifard SR and Heidary M and Jeda AS and Mohammadi T and Roshani M and Yousefimashouf R and Keyvani H and Darvishmotevalli M and Sani MZ and Karampoor S}, title = {The Emerging Role of Micrornas in the Severe Acute Respiratory Syndrome Coronavirus 2 (Sars-Cov-2) Infection}, journal = {International Immunopharmacology}, volume = {90}, number = {}, pages = {-}, year = {2021} }
RIS	TY - JOUR AU - Mirzaei R AU - Mahdavi F AU - Badrzadeh F AU - Hosseinifard SR AU - Heidary M AU - Jeda AS AU - Mohammadi T AU - Roshani M AU - Yousefimashouf R AU - Keyvani H AU - Darvishmotevalli M AU - Sani MZ AU - Karampoor S TI - The Emerging Role of Micrornas in the Severe Acute Respiratory Syndrome Coronavirus 2 (Sars-Cov-2) Infection JO - International Immunopharmacology VL - 90 IS - SP - EP - PY - 2021 ER -

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