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Circulating Microrna: A New Candidate for Diagnostic Biomarker in Neuroblastoma Publisher Pubmed



Mohammadi M1 ; Goodarzi M2 ; Jaafari MR3 ; Mirzaei HR4 ; Mirzaei H5
Authors
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Authors Affiliations
  1. 1. Hepatitis Research Center and Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Lorestan University of Medical Sciences, Khorramabad, Iran
  2. 2. Department of Biosystems, Faculty of Bioscience Engineering, Katholieke Universiteit Leuven - KU Leuven, Heverlee, Belgium
  3. 3. Biotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
  4. 4. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, 1417613151, Iran
  5. 5. Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, 9177948564, Iran

Source: Cancer Gene Therapy Published:2016


Abstract

Neuroblastoma (NB) is known as a pediatric neoplasm that is associated with variable histopathological features. The use of biomarkers contributes to the monitoring and treatment of various malignancies such as NB. The identification of novel biomarkers such as (epi)genetic biomarkers and microRNAs (miRNAs) in NB has led to better treatments of NB. Among them, miRNAs have emerged as powerful tools in diagnosis, prognosis and therapeutic biomarkers for patients with NB. Circulating biomarkers such as circulating miRNAs present in body fluids (for example, plasma, serum and urine) provided an interesting field of study in NB treatment. The miRNAs have central roles in different pathogenic events in various malignancies such as NB. Hence, these molecules can be a suitable candidate for monitoring and treating NB patients. Here, we summarize some miRNAs as potential prognosis, diagnosis and therapeutic biomarkers in NB. © 2016 Nature America, Inc., part of Springer Nature. All rights reserved.
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