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Emerging Role of Nanotechnology in Treatment of Non-Alcoholic Fatty Liver Disease (Nafld) Publisher



Moghtadaie A1 ; Mahboobi H1 ; Fatemizadeh S2 ; Kamal MA3, 4, 5, 6
Authors
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Authors Affiliations
  1. 1. Clinical Fellow in Gastroenterology and Hepatology, Digestive Disease Research Institute, Department of Gastroenterology and Hepatology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Gastroenterology and Hepatology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, China
  4. 4. King Fahd Medical Research Center, King Abdulaziz University, Jeddah, 21589, Saudi Arabia
  5. 5. Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka, 1207, Bangladesh
  6. 6. Enzymoics, Novel Global Community Educational Foundation, 7 Peterlee place, Hebersham, 2770, NSW, Australia

Source: EXCLI Journal Published:2023


Abstract

Non-alcoholic fatty liver disease (NAFLD) is a prevailing health challenge that requires urgent innovative interventions. This review explores the role of nanotechnology as a promising potential in the treatment of NAFLD. It delineates the limitations of the current management strategies for NAFLD and highlights the new nanotechnology-based treatments including nanoemulsions, liposomes, micelles, polymeric nanoparticles, nanogels, inorganic nanoparticles, and zinc oxide nanoparticles. Despite the optimism surrounding the nanotechnological approach, the review underscores the need to address the limitations such as technical challenges, potential toxicity, and ethical considerations that impede the practical application of nanotechnology in NAFLD management. It advocates for collaborative efforts from researchers, clinicians, ethicists, and policymakers to achieve safe, effective, and equitable nanotechnology-based treatments for NAFLD. © 2023, Leibniz Research Centre for Working Environment and Human Factors. All rights reserved.
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